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Evaluating natural language generation (NLG) systems in the medical domain presents unique challenges due to the critical demands for accuracy, relevance, and domain-specific expertise. Traditional automatic evaluation metrics, such as…

Computation and Language · Computer Science 2025-09-17 Wen-wai Yim , Asma Ben Abacha , Zixuan Yu , Robert Doerning , Fei Xia , Meliha Yetisgen

Objective: Large language models (LLMs) are attracting increasing interest in healthcare. This commentary evaluates the potential of LLMs to improve clinical prediction models (CPMs) for diagnostic and prognostic tasks, with a focus on…

Computers and Society · Computer Science 2025-11-07 Yusuf Yildiz , Goran Nenadic , Meghna Jani , David A. Jenkins

Summarizing patient clinical notes is vital for reducing documentation burdens. Current manual summarization makes medical staff struggle. We propose an automatic method using LLMs, but long inputs cause LLMs to lose context, reducing…

Artificial Intelligence · Computer Science 2024-11-15 Guoqing Zhang , Keita Fukuyama , Kazumasa Kishimoto , Tomohiro Kuroda

The records of a clinical encounter can be extensive and complex, thus placing a premium on tools that can extract and summarize relevant information. This paper introduces the task of generating discharge summaries for a clinical…

Computation and Language · Computer Science 2021-04-29 Han-Chin Shing , Chaitanya Shivade , Nima Pourdamghani , Feng Nan , Philip Resnik , Douglas Oard , Parminder Bhatia

Large language models (LLMs) are increasingly used to extract clinical data from electronic health records (EHRs), offering significant improvements in scalability and efficiency for real-world data (RWD) curation in oncology. However, the…

The rising prevalence of eye diseases poses a growing public health burden. Large language models (LLMs) offer a promising path to reduce documentation workload and support clinical decision-making. However, few have been tailored for…

Electronic Health Records (EHRs) have been increasingly used as real-world evidence (RWE) to support the discovery and validation of new drug indications. This paper surveys current approaches to EHR-based drug repurposing, covering data…

Applications · Statistics 2025-11-21 Nabasmita Talukdar , Xiaodan Zhang , Shreya Paithankar , Hui Wang , Bin Chen

Background: Patient recruitment in clinical trials is hindered by complex eligibility criteria and labor-intensive chart reviews. Prior research using text-only models have struggled to address this problem in a reliable and scalable way…

Computation and Language · Computer Science 2025-03-20 Anatole Callies , Quentin Bodinier , Philippe Ravaud , Kourosh Davarpanah

Large language models (LLMs) have demonstrated impressive capabilities in natural language understanding and generation, but the quality bar for medical and clinical applications is high. Today, attempts to assess models' clinical knowledge…

Electronic Health Records (EHRs) provide vital contextual information to radiologists and other physicians when making a diagnosis. Unfortunately, because a given patient's record may contain hundreds of notes and reports, identifying…

Information retrieval (IR) systems play a critical role in navigating information overload across various applications. Existing IR benchmarks primarily focus on simple queries that are semantically analogous to single- and multi-hop…

Information Retrieval · Computer Science 2025-11-25 Ganlin Xu , Zhitao Yin , Linghao Zhang , Jiaqing Liang , Weijia Lu , Xiaodong Zhang , Zhifei Yang , Sihang Jiang , Deqing Yang

This study reviewed the use of Large Language Models (LLMs) in healthcare, focusing on their training corpora, customization techniques, and evaluation metrics. A systematic search of studies from 2021 to 2024 identified 61 articles. Four…

Computation and Language · Computer Science 2025-02-18 Shuqi Yang , Mingrui Jing , Shuai Wang , Jiaxin Kou , Manfei Shi , Weijie Xing , Yan Hu , Zheng Zhu

Large Language Models (LLMs) have demonstrated impressive capabilities across a range of scientific tasks including mathematics, physics, and chemistry. Despite their successes, the effectiveness of LLMs in handling complex statistical…

Computation and Language · Computer Science 2024-10-11 Yizhang Zhu , Shiyin Du , Boyan Li , Yuyu Luo , Nan Tang

Clinician notes are a rich source of patient information but often contain inconsistencies due to varied writing styles, colloquialisms, abbreviations, medical jargon, grammatical errors, and non-standard formatting. These inconsistencies…

Computation and Language · Computer Science 2025-01-03 Daniel B. Hier , Michael D. Carrithers , Thanh Son Do , Tayo Obafemi-Ajayi

Many large language models (LLMs) for medicine have largely been evaluated on short texts, and their ability to handle longer sequences such as a complete electronic health record (EHR) has not been systematically explored. Assessing these…

Computation and Language · Computer Science 2023-11-17 Mihir Parmar , Aakanksha Naik , Himanshu Gupta , Disha Agrawal , Chitta Baral

The proliferation of Large Language Models (LLMs) presents transformative potential for healthcare, yet practical deployment is hindered by the absence of frameworks that assess real-world clinical utility. Existing benchmarks test static…

The deployment of Large Language Models (LLMs) in high-stakes clinical settings demands rigorous and reliable evaluation. However, existing medical benchmarks remain static, suffering from two critical limitations: (1) data contamination,…

Artificial Intelligence · Computer Science 2026-02-12 Zhiling Yan , Dingjie Song , Zhe Fang , Yisheng Ji , Xiang Li , Quanzheng Li , Lichao Sun

Electronic Health Records (EHRs) provide rich longitudinal clinical evidence that is central to medical decision-making, motivating the use of retrieval-augmented generation (RAG) to ground large language model (LLM) predictions. However,…

Artificial Intelligence · Computer Science 2026-01-30 Lang Cao , Qingyu Chen , Yue Guo

Long-form clinical summarization of hospital admissions has real-world significance because of its potential to help both clinicians and patients. The faithfulness of summaries is critical to their safe usage in clinical settings. To better…

Computation and Language · Computer Science 2023-03-08 Griffin Adams , Jason Zucker , Noémie Elhadad

The integration of multimodal Electronic Health Records (EHR) data has significantly improved clinical predictive capabilities. Leveraging clinical notes and multivariate time-series EHR, existing models often lack the medical context…

Artificial Intelligence · Computer Science 2024-02-13 Yinghao Zhu , Changyu Ren , Shiyun Xie , Shukai Liu , Hangyuan Ji , Zixiang Wang , Tao Sun , Long He , Zhoujun Li , Xi Zhu , Chengwei Pan