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A critical challenge in single-cell RNA sequencing (scRNA-seq) integration is resolving the tension between eliminating batch effects and maintaining biological fidelity. While recent evidence indicates that batch effects manifest…

Machine Learning · Computer Science 2026-05-19 Xichen Yan , Zelin Zang , Changxi Chi , Jingbo Zhou , Chang Yu , Jinlin Wu , Shenghui Cheng , Fuji Yang , Jiebo Luo , Zhen Lei , Stan Z. Li

Biological sequence comparison is a key step in inferring the relatedness of various organisms and the functional similarity of their components. Thanks to the Next Generation Sequencing efforts, an abundance of sequence data is now…

Machine Learning · Computer Science 2016-09-13 Dhananjay Kimothi , Akshay Soni , Pravesh Biyani , James M. Hogan

The analysis of single-cell RNA sequencing (scRNA-seq) data often involves fitting a latent variable model to learn a low-dimensional representation for the cells. Validating such a model poses a major challenge. If we could sequence the…

Methodology · Statistics 2023-07-25 Anna Neufeld , Joshua Popp , Lucy L. Gao , Alexis Battle , Daniela Witten

Sequential algorithms are popular for experimental design, enabling emulation, optimisation and inference to be efficiently performed. For most of these applications bespoke software has been developed, but the approach is general and many…

Computation · Statistics 2021-10-18 Matthew A. Fisher , Onur Teymur , Chris. J. Oates

Similarity-based clustering and semi-supervised learning methods separate the data into clusters or classes according to the pairwise similarity between the data, and the pairwise similarity is crucial for their performance. In this paper,…

Machine Learning · Statistics 2017-09-06 Yingzhen Yang , Feng Liang , Nebojsa Jojic , Shuicheng Yan , Jiashi Feng , Thomas S. Huang

Can health entities collaboratively train deep learning models without sharing sensitive raw data? This paper proposes several configurations of a distributed deep learning method called SplitNN to facilitate such collaborations. SplitNN…

Machine Learning · Computer Science 2018-12-04 Praneeth Vepakomma , Otkrist Gupta , Tristan Swedish , Ramesh Raskar

Recent advancements in semi-supervised deep learning have introduced effective strategies for leveraging both labeled and unlabeled data to improve classification performance. This work proposes a semi-supervised framework that utilizes a…

Machine Learning · Computer Science 2025-05-21 Aydin Abedinia , Shima Tabakhi , Vahid Seydi

Machine learning models, and deep neural networks in particular, are increasingly deployed in risk-sensitive domains such as healthcare, environmental forecasting, and finance, where reliable quantification of predictive uncertainty is…

Machine Learning · Computer Science 2026-04-07 Asena Karolin Özdemir , Lars H. Heyen , Arvid Weyrauch , Achim Streit , Markus Götz , Charlotte Debus

We propose a method to facilitate exploration and analysis of new large data sets. In particular, we give an unsupervised deep learning approach to learning a latent representation that captures semantic similarity in the data set. The core…

Computer Vision and Pattern Recognition · Computer Science 2020-12-23 Gary B Huang , Huei-Fang Yang , Shin-ya Takemura , Pat Rivlin , Stephen M Plaza

Deep learning is significantly advancing the analysis of electroencephalography (EEG) data by effectively discovering highly nonlinear patterns within the signals. Data partitioning and cross-validation are crucial for assessing model…

Signal Processing · Electrical Eng. & Systems 2025-05-20 Federico Del Pup , Andrea Zanola , Louis Fabrice Tshimanga , Alessandra Bertoldo , Livio Finos , Manfredo Atzori

Semantic segmentation is essential in computer vision for various applications, yet traditional approaches face significant challenges, including the high cost of annotation and extensive training for supervised learning. Additionally, due…

Computer Vision and Pattern Recognition · Computer Science 2024-03-19 Yasufumi Kawano , Yoshimitsu Aoki

Due to the cross-domain distribution shift aroused from diverse medical imaging systems, many deep learning segmentation methods fail to perform well on unseen data, which limits their real-world applicability. Recent works have shown the…

Computer Vision and Pattern Recognition · Computer Science 2023-03-06 Shangqi Gao , Hangqi Zhou , Yibo Gao , Xiahai Zhuang

Big data sets must be carefully partitioned into statistically similar data subsets that can be used as representative samples for big data analysis tasks. In this paper, we propose the random sample partition (RSP) data model to represent…

Distributed, Parallel, and Cluster Computing · Computer Science 2019-06-11 Salman Salloum , Yulin He , Joshua Zhexue Huang , Xiaoliang Zhang , Tamer Z. Emara , Chenghao Wei , Heping He

Split Learning has been recently introduced to facilitate applications where user data privacy is a requirement. However, it has not been thoroughly studied in the context of Privacy-Preserving Record Linkage, a problem in which the same…

Cryptography and Security · Computer Science 2024-09-05 Michail Zervas , Alexandros Karakasidis

Semi-Supervised Semantic Segmentation reduces reliance on extensive annotations by using unlabeled data and state-of-the-art models to improve overall performance. Despite the success of deep co-training methods, their underlying mechanisms…

Computer Vision and Pattern Recognition · Computer Science 2025-03-17 Thuan Than , Nhat-Anh Nguyen-Dang , Dung Nguyen , Salwa K. Al Khatib , Ahmed Elhagry , Hai Phan , Yihui He , Zhiqiang Shen , Marios Savvides , Dang Huynh

Deep convolutional neural networks (CNNs) have greatly improved the Face Recognition (FR) performance in recent years. Almost all CNNs in FR are trained on the carefully labeled datasets containing plenty of identities. However, such…

Computer Vision and Pattern Recognition · Computer Science 2018-03-28 Wei Hu , Yangyu Huang , Fan Zhang , Ruirui Li , Wei Li , Guodong Yuan

We present a deep learning framework for probabilistic pixel-wise semantic segmentation, which we term Bayesian SegNet. Semantic segmentation is an important tool for visual scene understanding and a meaningful measure of uncertainty is…

Computer Vision and Pattern Recognition · Computer Science 2016-10-12 Alex Kendall , Vijay Badrinarayanan , Roberto Cipolla

Subsampling is a computationally efficient and scalable method to draw inference in large data settings based on a subset of the data rather than needing to consider the whole dataset. When employing subsampling techniques, a crucial…

Methodology · Statistics 2025-10-08 Amalan Mahendran , Helen Thompson , James M. McGree

In this paper, we introduce AdaSelection, an adaptive sub-sampling method to identify the most informative sub-samples within each minibatch to speed up the training of large-scale deep learning models without sacrificing model performance.…

Machine Learning · Computer Science 2023-06-21 Minghe Zhang , Chaosheng Dong , Jinmiao Fu , Tianchen Zhou , Jia Liang , Jia Liu , Bo Liu , Michinari Momma , Bryan Wang , Yan Gao , Yi Sun

Deep learning has revolutionized many industries by enabling models to automatically learn complex patterns from raw data, reducing dependence on manual feature engineering. However, deep learning algorithms are sensitive to input data, and…

Machine Learning · Computer Science 2025-07-21 Mert Sehri , Zehui Hua , Francisco de Assis Boldt , Patrick Dumond