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In the ongoing wave of impact driven by large language models (LLMs) like ChatGPT, the adaptation of LLMs to medical domain has emerged as a crucial research frontier. Since mainstream LLMs tend to be designed for general-purpose…

Computation and Language · Computer Science 2023-12-04 Issey Sukeda , Masahiro Suzuki , Hiroki Sakaji , Satoshi Kodera

Relation extraction is a fundamental problem in natural language processing. Most existing models are defined for relation extraction in the general domain. However, their performance on specific domains (e.g., biomedicine) is yet unclear.…

Computation and Language · Computer Science 2021-12-14 Yongkang Li

Instruction-tuned Large Language Models (LLMs) can perform a wide range of tasks given natural language instructions to do so, but they are sensitive to how such instructions are phrased. This issue is especially concerning in healthcare,…

Prompting Large Language Models (LLMs), or providing context on the expected model of operation, is an effective way to steer the outputs of such models to satisfy human desiderata after they have been trained. But in rapidly evolving…

Machine Learning · Computer Science 2025-08-08 Younwoo Choi , Muhammad Adil Asif , Ziwen Han , John Willes , Rahul G. Krishnan

Automatic relationship extraction (RE) from biomedical literature is critical for managing the vast amount of scientific knowledge produced each year. In recent years, utilizing pre-trained language models (PLMs) has become the prevalent…

Computation and Language · Computer Science 2025-11-04 Mario Sänger , Ulf Leser

Recent advances in NLP are brought by a range of large-scale pretrained language models (PLMs). These PLMs have brought significant performance gains for a range of NLP tasks, circumventing the need to customize complex designs for specific…

Computation and Language · Computer Science 2022-11-08 Xu Guo , Han Yu

The introduction of Large Language Models (LLMs), and the vast volume of publicly available medical data, amplified the application of NLP to the medical domain. However, LLMs are pretrained on data that are not explicitly relevant to the…

Computation and Language · Computer Science 2023-12-12 Chris Solomou

Fine-tuning is known to improve NLP models by adapting an initial model trained on more plentiful but less domain-salient examples to data in a target domain. Such domain adaptation is typically done using one stage of fine-tuning. We…

Computation and Language · Computer Science 2021-09-08 Haoran Xu , Seth Ebner , Mahsa Yarmohammadi , Aaron Steven White , Benjamin Van Durme , Kenton Murray

Recent releases of pre-trained Large Language Models (LLMs) have gained considerable traction, yet research on fine-tuning and employing domain-specific LLMs remains scarce. This study investigates approaches for fine-tuning and leveraging…

Computation and Language · Computer Science 2024-05-29 Cheonsu Jeong

This paper narrows the performance gap between small, specialized models and significantly larger general-purpose models through domain adaptation via continual pre-training and merging. We address the scarcity of specialized non-English…

Computation and Language · Computer Science 2026-04-22 Niclas Doll , Jasper Schulze Buschhoff , Shalaka Satheesh , Hammam Abdelwahab , Héctor Allende-Cid , Katrin Klug

There are many cases where LLMs are used for specific tasks in a single domain. These usually require less general, but more domain-specific knowledge. Highly capable, general-purpose state-of-the-art language models like GPT-4 or…

Machine Learning · Computer Science 2024-07-30 Tobias Kerner

Contextualized word embeddings derived from pre-trained language models (LMs) show significant improvements on downstream NLP tasks. Pre-training on domain-specific corpora, such as biomedical articles, further improves their performance.…

Computation and Language · Computer Science 2019-04-05 Qiao Jin , Bhuwan Dhingra , William W. Cohen , Xinghua Lu

Finetuning on narrow domains has become an essential tool to adapt Large Language Models (LLMs) to specific tasks and to create models with known unusual properties that are useful for research. We show that narrow finetuning creates strong…

Computation and Language · Computer Science 2026-03-06 Julian Minder , Clément Dumas , Stewart Slocum , Helena Casademunt , Cameron Holmes , Robert West , Neel Nanda

Large language models (LLMs) have shown potential in biomedical applications, leading to efforts to fine-tune them on domain-specific data. However, the effectiveness of this approach remains unclear. This study evaluates the performance of…

This project investigates the efficacy of Large Language Models (LLMs) in understanding and extracting scientific knowledge across specific domains and to create a deep learning framework: Knowledge AI. As a part of this framework, we…

Computation and Language · Computer Science 2024-08-12 Balaji Muralidharan , Hayden Beadles , Reza Marzban , Kalyan Sashank Mupparaju

While Large Language Models (LLMs) excel in world knowledge understanding, adapting them to specific subfields requires precise adjustments. Due to the model's vast scale, traditional global fine-tuning methods for large models can be…

Computer Vision and Pattern Recognition · Computer Science 2024-07-09 Jiawei Chen , Yue Jiang , Dingkang Yang , Mingcheng Li , Jinjie Wei , Ziyun Qian , Lihua Zhang

While deep learning techniques have shown promising results in many natural language processing (NLP) tasks, it has not been widely applied to the clinical domain. The lack of large datasets and the pervasive use of domain-specific language…

Computation and Language · Computer Science 2019-06-20 Jiin Nam , Seunghyun Yoon , Kyomin Jung

Fine-tuning of Large Language Models (LLMs) for downstream tasks, performed on domain-specific data has shown significant promise. However, commercial use of such LLMs is limited by the high computational cost required for their deployment…

Computation and Language · Computer Science 2025-03-06 Boris Nazarov , Darya Frolova , Yackov Lubarsky , Alexei Gaissinski , Pavel Kisilev

Recently, Large Language Models (LLM) have demonstrated impressive capability to solve a wide range of tasks. However, despite their success across various tasks, no prior work has investigated their capability in the biomedical domain yet.…

Computation and Language · Computer Science 2024-02-21 Israt Jahan , Md Tahmid Rahman Laskar , Chun Peng , Jimmy Huang

This work presents biomedical and clinical language models for Spanish by experimenting with different pretraining choices, such as masking at word and subword level, varying the vocabulary size and testing with domain data, looking for…