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Prompt tuning, or the conditioning of a frozen pretrained language model (PLM) with soft prompts learned from data, has demonstrated impressive performance on a wide range of NLP tasks. However, prompt tuning requires a large training…

Computation and Language · Computer Science 2022-10-24 Xu Guo , Boyang Li , Han Yu

Vision-language models (VLMs) are increasingly adapted through domain-specific fine-tuning, yet it remains unclear whether this improves reasoning beyond superficial visual cues, particularly in high-stakes domains like medicine. We…

Computer Vision and Pattern Recognition · Computer Science 2026-04-14 Oliver McLaughlin , Daniel Shubin , Carsten Eickhoff , Ritambhara Singh , William Rudman , Michal Golovanevsky

Despite their outstanding performance, large language models (LLMs) suffer notorious flaws related to their preference for simple, surface-level textual relations over full semantic complexity of the problem. This proposal investigates a…

Computation and Language · Computer Science 2022-06-20 Michal Štefánik

Large Language Models are traditionally finetuned on large instruction datasets. However recent studies suggest that small, high-quality datasets can suffice for general purpose instruction following. This lack of consensus surrounding…

Machine Learning · Computer Science 2023-12-29 Aditi Jha , Sam Havens , Jeremy Dohmann , Alex Trott , Jacob Portes

Recent breakthroughs in large language models (LLMs) offer unprecedented natural language understanding and generation capabilities. However, existing surveys on LLMs in biomedicine often focus on specific applications or model…

Effective biomedical data integration depends on automated term normalization, the mapping of natural language biomedical terms to standardized identifiers. This linking of terms to identifiers is essential for semantic interoperability.…

Computation and Language · Computer Science 2025-10-23 Suswitha Pericharla , Daniel B. Hier , Tayo Obafemi-Ajayi

We evaluate four state-of-the-art instruction-tuned large language models (LLMs) -- ChatGPT, Flan-T5 UL2, Tk-Instruct, and Alpaca -- on a set of 13 real-world clinical and biomedical natural language processing (NLP) tasks in English, such…

Computation and Language · Computer Science 2024-06-11 Yanis Labrak , Mickael Rouvier , Richard Dufour

Several recent works seek to adapt general-purpose large language models (LLMs) and vision-language models (VLMs) for medical applications through continued pretraining on publicly available biomedical corpora. These works typically claim…

Computation and Language · Computer Science 2025-07-01 Daniel P. Jeong , Pranav Mani , Saurabh Garg , Zachary C. Lipton , Michael Oberst

Due to the exponential growth of biomedical literature, event and relation extraction are important tasks in biomedical text mining. Most work only focus on relation extraction, and detect a single entity pair mention on a short span of…

Computation and Language · Computer Science 2020-05-08 Elaheh ShafieiBavani , Antonio Jimeno Yepes , Xu Zhong , David Martinez Iraola

Fine-tuning on task-specific question-answer pairs is a predominant method for enhancing the performance of instruction-tuned large language models (LLMs) on downstream tasks. However, in certain specialized domains, such as healthcare or…

Computation and Language · Computer Science 2024-10-18 Shuyang Jiang , Yusheng Liao , Ya Zhang , Yanfeng Wang , Yu Wang

This paper introduces an efficient strategy to transform Large Language Models (LLMs) into Multi-Modal Large Language Models (MLLMs). By conceptualizing this transformation as a domain adaptation process, i.e., transitioning from text…

Computation and Language · Computer Science 2023-12-19 Bingchen Zhao , Haoqin Tu , Chen Wei , Jieru Mei , Cihang Xie

This paper investigates the impact of domain-specific model fine-tuning and of reasoning mechanisms on the performance of question-answering (Q&A) systems powered by large language models (LLMs) and Retrieval-Augmented Generation (RAG).…

Artificial Intelligence · Computer Science 2024-04-23 Zooey Nguyen , Anthony Annunziata , Vinh Luong , Sang Dinh , Quynh Le , Anh Hai Ha , Chanh Le , Hong An Phan , Shruti Raghavan , Christopher Nguyen

Large language models (LLMs) have transformed natural language processing, yet face challenges in specialized tasks such as simulating opinions on environmental policies. This paper introduces a novel fine-tuning approach that integrates…

Computation and Language · Computer Science 2024-12-10 Haocheng Lin

Building systems that achieve a deeper understanding of language is one of the central goals of natural language processing (NLP). Towards this goal, recent works have begun to train language models on narrative datasets which require…

Computation and Language · Computer Science 2023-03-02 Khai Loong Aw , Mariya Toneva

Recently, large language models (LLMs) have outperformed human experts in predicting the results of neuroscience experiments (Luo et al., 2024). What is the basis for this performance? One possibility is that statistical patterns in that…

Neurons and Cognition · Quantitative Biology 2024-07-03 Xiaoliang Luo , Guangzhi Sun , Bradley C. Love

Large language models (LLMs) have significantly advanced Natural Language Processing (NLP) tasks in recent years. However, their universal nature poses limitations in scenarios requiring personalized responses, such as recommendation…

Computation and Language · Computer Science 2024-11-08 Stanisław Woźniak , Bartłomiej Koptyra , Arkadiusz Janz , Przemysław Kazienko , Jan Kocoń

Large language models (LLMs) are increasingly used in decision-making contexts, but when they present answers without signaling low confidence, users may unknowingly act on erroneous outputs. Prior work shows that LLMs maintain internal…

Computation and Language · Computer Science 2025-10-23 Mark Steyvers , Catarina Belem , Padhraic Smyth

The advancement of large language models (LLMs) has opened new frontiers in natural language processing, particularly in specialized domains like healthcare. In this paper, we propose the Incremental Curriculum-Based Fine-Tuning (ICFT)…

Computation and Language · Computer Science 2025-02-04 Robert Long , Eric Gonzalez , Harrison Fuller

Large Language Models (LLMs) have swiftly emerged as vital resources for different applications in the biomedical and healthcare domains; however, these models encounter issues such as generating inaccurate information or hallucinations.…

Computation and Language · Computer Science 2024-05-06 Mingchen Li , Halil Kilicoglu , Hua Xu , Rui Zhang

Recent foundational language models have shown state-of-the-art performance in many NLP tasks in zero- and few-shot settings. An advantage of these models over more standard approaches based on fine-tuning is the ability to understand…

Computation and Language · Computer Science 2024-04-16 Aleksandra Edwards , Jose Camacho-Collados
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