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Generating molecular structures with desired properties is a critical task with broad applications in drug discovery and materials design. We propose 3M-Diffusion, a novel multi-modal molecular graph generation method, to generate diverse,…

Machine Learning · Computer Science 2024-10-04 Huaisheng Zhu , Teng Xiao , Vasant G Honavar

The Belle~II electromagnetic calorimeter consists of 8376 CsI(Tl) scintillation crystals and is not only used for measuring electromagnetic particles but also for identifying and determining the position of hadrons, particularly…

High Energy Physics - Experiment · Physics 2026-04-23 Jonas Eppelt , Torben Ferber

Graph diffusion models have emerged as state-of-the-art techniques in graph generation; yet, integrating domain knowledge into these models remains challenging. Domain knowledge is particularly important in real-world scenarios, where…

Machine Learning · Computer Science 2024-12-09 Manuel Madeira , Clement Vignac , Dorina Thanou , Pascal Frossard

Diffusion probabilistic models (DPMs), widely recognized for their potential to generate high-quality samples, tend to go unnoticed in representation learning. While recent progress has highlighted their potential for capturing visual…

Machine Learning · Computer Science 2025-05-09 Dingshuo Chen , Shuchen Xue , Liuji Chen , Yingheng Wang , Qiang Liu , Shu Wu , Zhi-Ming Ma , Liang Wang

The extension of the longitudinal hadronic shower profile parameterization which takes into account non-compensations of calorimeters and the algorithm of the longitudinal hadronic shower profile curve making for a combined calorimeter are…

High Energy Physics - Experiment · Physics 2009-10-31 Y. A. Kulchitsky , V. B. Vinogradov

This study presents a geometric deep learning framework for predicting cold spray particle impact responses using finite element simulation data. A parametric dataset was generated through automated Abaqus simulations spanning a systematic…

Machine Learning · Computer Science 2026-03-17 Akshansh Mishra

Diffusion models have emerged as powerful generative models for graph generation, yet their use for conditional graph generation remains a fundamental challenge. In particular, guiding diffusion models on graphs under arbitrary reward…

Machine Learning · Computer Science 2025-05-27 Victor M. Tenorio , Nicolas Zilberstein , Santiago Segarra , Antonio G. Marques

Data-driven prediction of molecular properties presents unique challenges to the design of machine learning methods concerning data structure/dimensionality, symmetry adaption, and confidence management. In this paper, we present a…

Machine Learning · Computer Science 2019-01-31 Yu-Hang Tang , Wibe A. de Jong

Denoising diffusion models have shown great potential in multiple research areas. Existing diffusion-based generative methods on de novo 3D molecule generation face two major challenges. Since majority heavy atoms in molecules allow…

Machine Learning · Computer Science 2024-04-23 Can Xu , Haosen Wang , Weigang Wang , Pengfei Zheng , Hongyang Chen

We consider graph diffusion processes constructed from finite i.i.d. samples drawn from an unknown manifold embedded in ambient Euclidean space, where the graph affinity is defined by an ambient Gaussian kernel matrix. We show that the…

Machine Learning · Statistics 2026-05-26 Xiuyuan Cheng , Nan Wu

Diffusion models are known for generating high-quality images, causing serious security concerns. To combat this, most efforts rely on deep neural networks (e.g., CNNs and Transformers), while largely overlooking the potential of…

Computer Vision and Pattern Recognition · Computer Science 2026-04-16 Mengxin Fu , Yuezun Li

In nuclear, particle and astroparticle physics experiments, calorimeters are used to measure the properties of particles with kinetic energies that range from a fraction of 1 eV to 10^20 eV or more. These properties are not necessarily…

Instrumentation and Detectors · Physics 2018-10-17 Richard Wigmans

This dataset contains a detailed simulation output that allows the construction and study of different data representations for electromagnetic and hadronic showers in calorimeters. It is published so that optimal data representations can…

High Energy Physics - Experiment · Physics 2025-09-29 Anna Zaborowska , Peter McKeown

Graph generation generally aims to create new graphs that closely align with a specific graph distribution. Existing works often implicitly capture this distribution through the optimization of generators, potentially overlooking the…

Machine Learning · Computer Science 2024-07-19 Song Wang , Zhen Tan , Xinyu Zhao , Tianlong Chen , Huan Liu , Jundong Li

Motivated by the computational limitations of simulating interactions of particles in highly-granular detectors, there exists a concerted effort to build fast and exact machine-learning-based shower simulators. This work reports progress on…

Monte Carlo simulations are essential for physics analyses in high-energy physics, but their computational demands are continuously increasing. In LHCb, 90 % of computing resources are used for simulations, with the calorimeter simulation…

High Energy Physics - Experiment · Physics 2025-11-05 Michał Mazurek

High density electromagnetic sandwich calorimeters with high readout granularity are considered for many future collider and fix-target experiments. Optimization of the calorimeter structure from the point of view of the electromagnetic…

High Energy Physics - Experiment · Physics 2024-10-01 Oleksandr Borysov , Shan Huang , Kamil Zembaczyński , Aleksander Filip Żarnecki

Forecasting over graph-structured sensor networks demands models that capture both deterministic spatial trends and stochastic variability, while remaining efficient enough for repeated inference as new observations arrive. We propose…

Machine Learning · Computer Science 2026-04-02 Hanlin Dong , Arian Prabowo , Hao Xue , Ao Shuang , Tianyi Zhou , Flora D. Salim

Many generative tasks in chemistry and science involve distributions invariant to group symmetries (e.g., permutation and rotation). A common strategy enforces invariance and equivariance through architectural constraints such as…

Machine Learning · Computer Science 2026-02-17 Cai Zhou , Zijie Chen , Zian Li , Jike Wang , Kaiyi Jiang , Pan Li , Rose Yu , Muhan Zhang , Stephen Bates , Tommi Jaakkola

Diffusion generative models have emerged as a powerful framework for addressing problems in structural biology and structure-based drug design. These models operate directly on 3D molecular structures. Due to the unfavorable scaling of…

Biomolecules · Quantitative Biology 2024-05-10 Ian Dunn , David Ryan Koes
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