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Computational point-of-care (POC) sensors enable rapid, low-cost, and accessible diagnostics in emergency, remote and resource-limited areas that lack access to centralized medical facilities. These systems can utilize neural network-based…

Medical Physics · Physics 2025-12-25 Artem Goncharov , Rajesh Ghosh , Hyou-Arm Joung , Dino Di Carlo , Aydogan Ozcan

Purpose: Intensity-modulated proton therapy (IMPT) offers precise tumor coverage while sparing organs at risk (OARs) in head and neck (H&N) cancer. However, its sensitivity to anatomical changes requires frequent adaptation through online…

Pulmonary hypertension (PH) in newborns and infants is a complex condition associated with several pulmonary, cardiac, and systemic diseases contributing to morbidity and mortality. Therefore, accurate and early detection of PH is crucial…

Image and Video Processing · Electrical Eng. & Systems 2022-03-25 Hanna Ragnarsdottir , Laura Manduchi , Holger Michel , Fabian Laumer , Sven Wellmann , Ece Ozkan , Julia Vogt

Density functional theory (DFT) has been actively used and developed recently. DFT is an efficient instrument for describing a wide range of nanoscale phenomena: wetting transition, capillary condensation, adsorption, and others. In this…

Mesoscale and Nanoscale Physics · Physics 2020-07-21 Yuriy Kanygin

This study explores the fusion of a field-effect transistor (FET), a paper-based analytical cartridge, and the computational power of deep learning (DL) for quantitative biosensing via kinetic analyses. The FET sensors address the low…

Diffuse correlation spectroscopy (DCS) is a noninvasive optical technique that probes microvascular blood flow in deep tissues. Here, we present and validate a new on-chip hardware correlator for high-speed DCS measurements. The correlator…

Functional ultrasound imaging (fUSI) is a cutting-edge technology that measures changes in cerebral blood volume (CBV) by detecting backscattered echoes from red blood cells moving within its field of view (FOV). It offers high…

Neurons and Cognition · Quantitative Biology 2025-08-20 Jared Deighton , Shan Zhong , Kofi Agyeman , Wooseong Choi , Charles Liu , Darrin Lee , Vasileios Maroulas , Vasileios Christopoulos

Droplet microfluidics offers a versatile platform for analyzing liquid samples. Despite its potential, there is a lack of techniques that allow to reliably probe individual circulating droplets. The prospect of combining droplet…

Quantitative Methods · Quantitative Biology 2024-03-08 Marc Sulliger , Jaime Ortega Arroyo , Romain Quidant

Deep learning models have provided huge interpretation power for image-like data. Specifically, convolutional neural networks (CNNs) have demonstrated incredible acuity for tasks such as feature extraction or parameter estimation. Here we…

Thin-cap fibroatheroma (TCFA) and plaque rupture have been recognized as the most frequent risk factor for thrombosis and acute coronary syndrome. Intravascular optical coherence tomography (IVOCT) can identify TCFA and assess cap…

Motivation: Flow Injection Analysis coupled to High-Resolution Mass Spectrometry (FIA-HRMS) is a promising approach for high-throughput metabolomics. FIA-HRMS data, however, cannot be preprocessed with current software tools which rely on…

Quantitative Methods · Quantitative Biology 2017-08-15 Alexis Delabrière , Ulli Hohenester , Benoit Colsch , Christophe Junot , François Fenaille , Etienne Thévenot

Particle image velocimetry (PIV) is essential in experimental fluid dynamics. In the current work, we propose a new velocity field estimation paradigm, which achieves a synergetic combination of the deep learning method and the traditional…

Fluid Dynamics · Physics 2022-01-12 Qi Gao , Hongtao Lin , Han Tu , Haoran Zhu , Runjie Wei , Guoping Zhang , Xueming Shao

Particle agglutination assays are widely adapted immunological tests that are based on antigen-antibody interactions. Antibody-coated microscopic particles are mixed with a test sample that potentially contains the target antigen, as a…

Medical Physics · Physics 2021-07-20 Yi Luo , Hyou-Arm Joung , Sarah Esparza , Jingyou Rao , Omai Garner , Aydogan Ozcan

Accurate detection of pulmonary nodules with high sensitivity and specificity is essential for automatic lung cancer diagnosis from CT scans. Although many deep learning-based algorithms make great progress for improving the accuracy of…

Image and Video Processing · Electrical Eng. & Systems 2019-07-30 Jingya Liu , Liangliang Cao , Oguz Akin , Yingli Tian

Dynamic and precise measurement of cerebral blood flow velocity is crucial in neuroscience and the diagnosis of cerebrovascular diseases. Traditional color Doppler ultrasound can only measure the velocity component along the ultrasound…

Medical Physics · Physics 2025-04-25 Shaoyuan Yan , Yiming Ding , Guoao Ma , Yapeng Fu , Kailiang Xu , Dean Ta

Background: To develop an artificial intelligence system that can accurately identify acute non-traumatic intracranial hemorrhage (ICH) etiology based on non-contrast CT (NCCT) scans and investigate whether clinicians can benefit from it in…

Image and Video Processing · Electrical Eng. & Systems 2023-02-03 Meng Zhao , Yifan Hu , Ruixuan Jiang , Yuanli Zhao , Dong Zhang , Yan Zhang , Rong Wang , Yong Cao , Qian Zhang , Yonggang Ma , Jiaxi Li , Shaochen Yu , Wenjie Li , Ran Zhang , Yefeng Zheng , Shuo Wang , Jizong Zhao

Acute Coronary Syndrome (ACS) is a syndrome caused by a decrease in blood flow in the coronary arteries. The ACS is usually related to coronary thrombosis and is primarily caused by plaque rupture followed by plaque erosion and calcified…

Computer Vision and Pattern Recognition · Computer Science 2020-05-22 Tae Joon Jun , Soo-Jin Kang , June-Goo Lee , Jihoon Kweon , Wonjun Na , Daeyoun Kang , Dohyeun Kim , Daeyoung Kim , Young-Hak Kim

Purpose: Lung disease assessment in precapillary pulmonary hypertension (PH) is essential for appropriate patient management. This study aims to develop an artificial intelligence (AI) deep learning model for lung texture classification in…

Image and Video Processing · Electrical Eng. & Systems 2023-03-21 Michael J. Sharkey , Krit Dwivedi , Samer Alabed , Andrew J. Swift

CT Perfusion (CTP) imaging has gained importance in the diagnosis of acute stroke. Conventional perfusion analysis performs a deconvolution of the measurements and thresholds the perfusion parameters to determine the tissue status. We…

Since its inception, velocity map imaging (VMI) has been a powerful tool for measuring the 2D momentum distribution of photoelectrons generated by strong laser fields. There has been continued interest in expanding it into 3D measurements…