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Designing de novo proteins beyond those found in nature holds significant promise for advancements in both scientific and engineering applications. Current methodologies for protein design often rely on AI-based models, such as surrogate…
Modern Protein Language Models (PLMs) apply transformer-based model architectures from natural language processing to biological sequences, predicting a variety of protein functions and properties. However, protein language has key…
This paper explores the use of Large Language Models (LLMs) and in particular ChatGPT in programming, source code analysis, and code generation. LLMs and ChatGPT are built using machine learning and artificial intelligence techniques, and…
Large Language Models (LLMs), such as ChatGPT, have become widely popular and widely used in various software engineering tasks such as refactoring, testing, code review, and program comprehension. Although recent studies have examined the…
Prompt engineering is an increasingly important skill set needed to converse effectively with large language models (LLMs), such as ChatGPT. Prompts are instructions given to an LLM to enforce rules, automate processes, and ensure specific…
Large language models (LLMs), such as ChatGPT, have received substantial attention due to their capabilities for understanding and generating human language. While there has been a burgeoning trend in research focusing on the employment of…
Large language model (LLM) applications, such as ChatGPT, are a powerful tool for online information-seeking (IS) and problem-solving tasks. However, users still face challenges initializing and refining prompts, and their cognitive…
Proteins adopt multiple structural conformations to perform their diverse biological functions, and understanding these conformations is crucial for advancing drug discovery. Traditional physics-based simulation methods often struggle with…
Generative Large Language Models (gLLMs), such as ChatGPT, are increasingly being used in communication research for content analysis. Studies show that gLLMs can outperform both crowd workers and trained coders, such as research…
Conversational systems based on Large Language Models (LLMs), such as ChatGPT, show exceptional proficiency in context understanding and response generation. However, despite their impressive capabilities, they still possess limitations,…
Over the last few years, large language models (LLMs) have emerged as the most important breakthroughs in natural language processing (NLP) that fundamentally transform research and developments in the field. ChatGPT represents one of the…
Robots are increasingly common in industry and daily life, such as in nursing homes where they can assist staff. A key challenge is developing intuitive interfaces for easy communication. The use of Large Language Models (LLMs) like GPT-4…
Large language models (LLMs) have demonstrated notable proficiency in code generation, with numerous prior studies showing their promising capabilities in various development scenarios. However, these studies mainly provide evaluations in…
Understanding the relationships between protein sequence, structure and function is a long-standing biological challenge with manifold implications from drug design to our understanding of evolution. Recently, protein language models have…
This paper presents prompt design techniques for software engineering, in the form of patterns, to solve common problems when using large language models (LLMs), such as ChatGPT to automate common software engineering activities, such as…
Recent research has explored the creation of questions from code submitted by students. These Questions about Learners' Code (QLCs) are created through program analysis, exploring execution paths, and then creating code comprehension…
Identification of protein-protein interactions (PPIs) helps derive cellular mechanistic understanding, particularly in the context of complex conditions such as neurodegenerative disorders, metabolic syndromes, and cancer. Large Language…
Interest in Large Language Models (LLMs) has increased drastically since the emergence of ChatGPT and the outstanding positive societal response to the ease with which it performs tasks in Natural Language Processing (NLP). The triumph of…
Large Language Models (LLMs) such as ChatGPT demonstrated the potential to replicate human language abilities through technology, ranging from text generation to engaging in conversations. However, it remains controversial to what extent…
ChatGPT has drawn considerable attention from both the general public and domain experts with its remarkable text generation capabilities. This has subsequently led to the emergence of diverse applications in the field of biomedicine and…