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The challenge of removing cancerous cells lies in the limitation of organ at risk, which restricts the ability to increase the radiation dose adequately for enhancing treatment effectiveness. This survey provides a comprehensive overview of…

Medical Physics · Physics 2023-07-27 Amir Moslemi , Navid Khaledi

Heuristic search-based planning techniques are commonly used for motion planning on discretized spaces. The performance of these algorithms is heavily affected by the resolution at which the search space is discretized. Typically a fixed…

Robotics · Computer Science 2020-04-15 Wei Du , Fahad Islam , Maxim Likhachev

Machine learning is increasingly used to select which individuals receive limited-resource interventions in domains such as human services, education, development, and more. However, it is often not apparent what the right quantity is for…

Machine Learning · Computer Science 2025-03-20 Vibhhu Sharma , Bryan Wilder

There are several different modalities, e.g., surgery, chemotherapy, and radiotherapy, that are currently used to treat cancer. It is common practice to use a combination of these modalities to maximize clinical outcomes, which are often…

Optimization and Control · Mathematics 2019-09-27 Kelsey Maass , Minsun Kim

One of the grand challenges in intensity-modulated radiotherapy (IMRT) planning is to optimize the beam angles in a reasonable computation time. To demonstrate the value of prior knowledge on improving the efficiency of beam angle…

Medical Physics · Physics 2018-11-06 Yong-Jie Li

Proton therapy offers significant advantages due to its unique physical and biological properties, particularly the Bragg peak, enabling precise dose delivery to tumors while sparing healthy tissues. However, the clinical implementation is…

Radiotherapy aims to deliver a prescribed dose to the tumor while sparing neighboring organs at risk (OARs). Increasingly complex treatment techniques such as volumetric modulated arc therapy (VMAT), stereotactic radiosurgery (SRS),…

Medical Physics · Physics 2023-10-23 Elahheh Salari , Jing Wang , Jacob Wynne , Chih-Wei Chang , Xiaofeng Yang

In the last few years, the formulation of real-world optimization problems and their efficient solution via metaheuristic algorithms has been a catalyst for a myriad of research studies. In spite of decades of historical advancements on the…

In today's day and time solving real-world complex problems has become fundamentally vital and critical task. Many of these are combinatorial problems, where optimal solutions are sought rather than exact solutions. Traditional optimization…

Neural and Evolutionary Computing · Computer Science 2024-09-05 Pravin S Game , Vinod Vaze , Emmanuel M

Most metaheuristic algorithms rely on a few searched solutions to guide later searches during the convergence process for a simple reason: the limited computing resource of a computer makes it impossible to retain all the searched…

Artificial Intelligence · Computer Science 2023-06-02 Chun-Wei Tsai , Yi-Cheng Yang , Tzu-Chieh Tang , Che-Wei Hsu

Fluence map optimization for intensity-modulated radiation therapy planning can be formulated as a large-scale inverse problem with competing objectives and constraints associated with the tumors and organs-at-risk. Unfortunately,…

Optimization and Control · Mathematics 2022-02-17 Kelsey Maass , Minsun Kim , Aleksandr Aravkin

One of the main goals of sequential, multiple assignment, randomized trials (SMART) is to find the most efficacious design embedded dynamic treatment regimes. The analysis method known as multiple comparisons with the best (MCB) allows…

Methodology · Statistics 2020-08-07 William J. Artman , Ashkan Ertefaie , Kevin G. Lynch , James R. McKay

Radiation treatment planning involves optimization over a large number of voxels, many of which carry limited information about the clinical problem. We propose an approach to reduce the large optimization problem by only using a…

Medical Physics · Physics 2024-08-12 Sebastian Mair , Anqi Fu , Jens Sjölund

Online tuning of real-world plants is a complex optimisation problem that continues to require manual intervention by experienced human operators. Autonomous tuning is a rapidly expanding field of research, where learning-based methods,…

Significant evidence has become available that emphasizes the importance of personalization in medicine. In fact, it has become a common belief that personalized medicine is the future of medicine. The core of personalized medicine is the…

Methodology · Statistics 2020-04-30 Qiong Zhang , Amin Khademi , Yongjia Song

Protontherapy is hadrontherapy fastest-growing modality and a pillar in the battle against cancer. Hadrontherapy superiority lies in its inverted depth-dose profile, hence tumour-confined irradiation. Protons, however, lack distinct…

Metaheuristics are stochastic optimization algorithms that mimic natural processes to find optimal solutions to complex problems. The success of metaheuristics largely depends on the ability to effectively explore and exploit the search…

Neural and Evolutionary Computing · Computer Science 2024-11-26 Salar Farahmand-Tabar

Machine learning-based inverse materials discovery has attracted enormous attention recently due to its flexibility in dealing with black box models. Yet, many metaheuristic algorithms are not as widely applied to materials discovery…

Materials Science · Physics 2023-12-15 Hanfeng Zhai , Hongxia Hao , Jingjie Yeo

Mobile robotic platforms are an indispensable tool for various scientific and industrial applications. Robots are used to undertake missions whose execution is constrained by various factors, such as the allocated time or their remaining…

Robotics · Computer Science 2018-01-12 Nikolaos Tsiogkas , David M. Lane

A dynamical system model for tumor -- immune system interaction together with a method to mimic radiation therapy are proposed. A large population of virtual patients is simulated following an ideal radiation treatment. A characteristic…

Populations and Evolution · Quantitative Biology 2007-06-28 O. Sotolongo-Grau , D. Rodriguez-Perez , J. A. Santos-Miranda , O. Sotolongo-Costa , J. C. Antoranz