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Whole Slide Images (WSIs) present a challenging computer vision task due to their gigapixel size and presence of numerous artefacts. Yet they are a valuable resource for patient diagnosis and stratification, often representing the gold…

Computer Vision and Pattern Recognition · Computer Science 2023-10-05 Amaya Gallagher-Syed , Luca Rossi , Felice Rivellese , Costantino Pitzalis , Myles Lewis , Michael Barnes , Gregory Slabaugh

Delineation of cancerous regions in gigapixel whole slide images (WSIs) is a crucial diagnostic procedure in digital pathology. This process is time-consuming because of the large search space in the gigapixel WSIs, causing chances of…

Image and Video Processing · Electrical Eng. & Systems 2020-07-21 Hsien-Tzu Cheng , Chun-Fu Yeh , Po-Chen Kuo , Andy Wei , Keng-Chi Liu , Mong-Chi Ko , Kuan-Hua Chao , Yu-Ching Peng , Tyng-Luh Liu

Whole slide images~(WSIs) are digitized images of tissues placed in glass slides using advanced scanners. The digital processing of WSIs is challenging as they are gigapixel images and stored in multi-resolution format. A common challenge…

Image and Video Processing · Electrical Eng. & Systems 2023-10-30 Saba Heidari Gheshlaghi , Milan Aryal , Nasim Yahyasoltani , Masoud Ganji

The emergence of foundation models in computational pathology has transformed histopathological image analysis, with whole slide imaging (WSI) diagnosis being a core application. Traditionally, weakly supervised fine-tuning via multiple…

Computer Vision and Pattern Recognition · Computer Science 2025-03-03 Jiawen Li , Jiali Hu , Qiehe Sun , Renao Yan , Minxi Ouyang , Tian Guan , Anjia Han , Chao He , Yonghong He

Whole slide image (WSI) analysis has become increasingly important in the medical imaging community, enabling automated and objective diagnosis, prognosis, and therapeutic-response prediction. However, in clinical practice, the…

Computer Vision and Pattern Recognition · Computer Science 2023-08-28 Yanyan Huang , Weiqin Zhao , Shujun Wang , Yu Fu , Yuming Jiang , Lequan Yu

Multiple Instance Learning (MIL) has emerged as the best solution for Whole Slide Image (WSI) classification. It consists of dividing each slide into patches, which are treated as a bag of instances labeled with a global label. MIL includes…

Computer Vision and Pattern Recognition · Computer Science 2025-05-05 Ali Mammadov , Loic Le Folgoc , Julien Adam , Anne Buronfosse , Gilles Hayem , Guillaume Hocquet , Pietro Gori

Whole Slide Image (WSI) classification has very significant applications in clinical pathology, e.g., tumor identification and cancer diagnosis. Currently, most research attention is focused on Multiple Instance Learning (MIL) using static…

Computer Vision and Pattern Recognition · Computer Science 2025-04-17 Jiaxiang Gou , Luping Ji , Pei Liu , Mao Ye

Whole slide images (WSIs) are high-resolution, gigapixel sized images that pose significant computational challenges for traditional machine learning models due to their size and heterogeneity.In this paper, we present a scalable and…

Computer Vision and Pattern Recognition · Computer Science 2025-01-22 Ravi Kant Gupta , Shounak Das , Ardhendu Sekhar , Amit Sethi

Automatic integration of whole slide images (WSIs) and gene expression profiles has demonstrated substantial potential in precision clinical diagnosis and cancer progression studies. However, most existing studies focus on individual gene…

Computer Vision and Pattern Recognition · Computer Science 2026-01-14 Junzhuo Liu , Xuemei Du , Daniel Reisenbuchler , Ye Chen , Markus Eckstein , Christian Matek , Friedrich Feuerhake , Dorit Merhof

Since the emergence of the ImageNet dataset, the pretraining and fine-tuning approach has become widely adopted in computer vision due to the ability of ImageNet-pretrained models to learn a wide variety of visual features. However, a…

Computer Vision and Pattern Recognition · Computer Science 2024-10-22 Pablo Meseguer , Rocío del Amor , Adrian Colomer , Valery Naranjo

Deep Learning-based computational pathology algorithms have demonstrated profound ability to excel in a wide array of tasks that range from characterization of well known morphological phenotypes to predicting non-human-identifiable…

Image and Video Processing · Electrical Eng. & Systems 2020-09-24 Ming Y. Lu , Dehan Kong , Jana Lipkova , Richard J. Chen , Rajendra Singh , Drew F. K. Williamson , Tiffany Y. Chen , Faisal Mahmood

Background: The use of whole slide imaging (WSI) for digital pathology has recently been cleared for primary diagnosis in the US. A conventional WSI system scans the tissue slide to different positions and acquires the digital images. In a…

Image and Video Processing · Electrical Eng. & Systems 2019-07-26 Shaowei Jiang , Zichao Bian , Xizhi Huang , Pengming Song , He Zhang , Yongbing Zhang , Guoan Zheng

Multiple Instance Learning (MIL) methods have succeeded remarkably in histopathology whole slide image (WSI) analysis. However, most MIL models only offer attention-based explanations that do not faithfully capture the model's decision…

Computer Vision and Pattern Recognition · Computer Science 2025-07-17 Susu Sun , Dominique van Midden , Geert Litjens , Christian F. Baumgartner

Multimodal survival methods combining gigapixel histology whole-slide images (WSIs) and transcriptomic profiles are particularly promising for patient prognostication and stratification. Current approaches involve tokenizing the WSIs into…

Computer Vision and Pattern Recognition · Computer Science 2024-07-02 Andrew H. Song , Richard J. Chen , Guillaume Jaume , Anurag J. Vaidya , Alexander S. Baras , Faisal Mahmood

This paper introduces the novel concept of few-shot weakly supervised learning for pathology Whole Slide Image (WSI) classification, denoted as FSWC. A solution is proposed based on prompt learning and the utilization of a large language…

Computer Vision and Pattern Recognition · Computer Science 2024-01-30 Linhao Qu , Xiaoyuan Luo , Kexue Fu , Manning Wang , Zhijian Song

Current approaches for classification of whole slide images (WSI) in digital pathology predominantly utilize a two-stage learning pipeline. The first stage identifies areas of interest (e.g. tumor tissue), while the second stage processes…

Computer Vision and Pattern Recognition · Computer Science 2022-07-20 Marvin Teichmann , Andre Aichert , Hanibal Bohnenberger , Philipp Ströbel , Tobias Heimann

Multiple instance learning (MIL) has emerged as a popular method for classifying histopathology whole slide images (WSIs). However, existing approaches typically rely on pre-trained models from large natural image datasets, such as…

Computer Vision and Pattern Recognition · Computer Science 2023-03-24 Yi Lin , Zhongchen Zhao , Zhengjie ZHU , Lisheng Wang , Kwang-Ting Cheng , Hao Chen

Whole Slide Images (WSIs) play a crucial role in accurate cancer diagnosis and prognosis, as they provide tissue details at the cellular level. However, the rapid growth of computational tasks involving WSIs poses significant challenges.…

Computer Vision and Pattern Recognition · Computer Science 2025-10-30 Doanh C. Bui , Hoai Luan Pham , Vu Trung Duong Le , Tuan Hai Vu , Van Duy Tran , Khang Nguyen , Yasuhiko Nakashima

Digital pathology and the integration of artificial intelligence (AI) models have revolutionized histopathology, opening new opportunities. With the increasing availability of Whole Slide Images (WSIs), there's a growing demand for…

Image and Video Processing · Electrical Eng. & Systems 2024-04-30 Areej Alsaafin , Peyman Nejat , Abubakr Shafique , Jibran Khan , Saghir Alfasly , Ghazal Alabtah , H. R. Tizhoosh

In recent years, the use of deep learning (DL) methods, including convolutional neural networks (CNNs) and vision transformers (ViTs), has significantly advanced computational pathology, enhancing both diagnostic accuracy and efficiency.…