Related papers: Proton-CAT: a Novel Strategy for Enhanced Proton T…
Proton beam therapy can potentially offer improved treatment for cancers of the head and neck and in paediatric patients. There has been a sharp uptake of proton beam therapy in recent years as improved delivery techniques and patient…
Intensity modulated proton therapy (IMPT) is an advanced cancer treatment modality that offers significant advantages over conventional X-ray therapies, particularly in its ability to minimize radiation dose beyond the tumor target. This…
Cancer therapy using protons and heavier ions such as carbon has demonstrated advantages over other radiotherapy treatments. To bring about the next generation of clinical facilities, the requirements are likely to reduce the footprint,…
Proton Computed Tomography (pCT) provides a promising solution to enhance the accuracy of Relative Stopping Power (RSP) required for proton therapy planning. This research introduces a novel high-granularity pCT architecture that…
Purpose: Proton therapy provides superior dose conformity compared to photon therapy, but its treatment planning is challenged by sensitivity to anatomical changes, setup/range uncertainties, and computational complexity. This review…
We propose a series of simulations about the potential use of Boron isotopes to trigger neutron-free (aneutronic) nuclear reactions in cancer cells through the interaction with an incoming energetic proton beam, thus resulting in the…
Background and purpose: IMPT faces challenges in lung cancer treatment, like maintaining plan robustness for moving tumors against setup, range errors, and interplay effects. Proton Arc Therapy (PAT) is an alternative to maintain target…
During proton therapy, the beam flux decreases due to inelastic interactions with nuclei. At the highest energies used in proton therapy around 25\% protons initiate nuclear reactions. This report presents the cross section measurements of…
As depth increases, linear energy transfer (LET) rises toward the distal edge of the Bragg peak, boosting the radiobiological effectiveness (RBE). To manage the biological variation and limit normal-tissue damage, LET-modifying objective…
Intensity-modulated proton therapy (IMPT) employs proton radiation rather than conventional X-rays to treat cancerous tumors. This approach offers significant advantages by minimizing the radiation exposure of surrounding healthy tissue,…
A target composition scheme to optimize the combined proton acceleration regime is presented and verified by two-dimensional particle-in-cell (2D PIC) simulations by using an ultra-intense circularly-polarized (CP) laser pulse irradiating…
Boron neutron capture therapy (BNCT) leverages the nuclear reaction between thermal neutrons and boron-10 (B-10) atoms to induce selective tumor cell death. The spatial and quantum mechanical overlap between the neutron wavefunction and…
Proton arc therapy (PAT) has emerged as a promising approach for improving dose distribution, but also enabling simpler and faster treatment delivery in comparison to conventional proton treatments. However, the delivery speed achievable in…
A work recently published experimentally demonstrates an increase in the radiobiological efficacy of clinical proton beams when a tumour is treated in the presence of a concentration of 11B. The paper, for the first time, demonstrates the…
This article examines the critical role of fast Monte Carlo dose calculations in advancing proton therapy techniques, particularly in the context of increasing treatment customization and precision. As adaptive radiotherapy and other…
Optimizing laser and plasma parameters is crucial for enhancing accelerated proton energy in laser-driven proton acceleration with finite laser energy for applications such as cancer therapy. Tight focusing plays a significant role in…
Laser acceleration promises innovation in particle beam therapy of cancer where an ultra-compact accelerator system for cancer beam therapy can become affordable to a broad range of patients. This is not feasible without the introduction of…
We employ a multi-scale mechanistic approach to investigate radiation induced cell toxicities and deactivation mechanisms as a function of linear energy transfer in hadron therapy. Our theoretical model consists of a system of Markov chains…
Nitrogen doping of the carbon is an important method to improve the performance and durability of catalysts for proton exchange membrane fuel cells by platinum-nitrogen and carbon-nitrogen bonds. This study shows that p-phenyl groups and…
It has been known for about sixty years that proton and heavy ion therapy is a very powerful radiation procedure for treating tumours. It has an innate ability to irradiate tumours with greater doses and spatial selectivity compared with…