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Large-scale clinical data is invaluable to driving many computational scientific advances today. However, understandable concerns regarding patient privacy hinder the open dissemination of such data and give rise to suboptimal siloed…

Computation and Language · Computer Science 2019-05-23 Oren Melamud , Chaitanya Shivade

The availability of genomic data is essential to progress in biomedical research, personalized medicine, etc. However, its extreme sensitivity makes it problematic, if not outright impossible, to publish or share it. As a result, several…

Genomics · Quantitative Biology 2022-01-19 Bristena Oprisanu , Georgi Ganev , Emiliano De Cristofaro

Clinical notes often describe the most important aspects of a patient's physiology and are therefore critical to medical research. However, these notes are typically inaccessible to researchers without prior removal of sensitive protected…

Computation and Language · Computer Science 2018-03-08 Willie Boag , Tristan Naumann , Peter Szolovits

The digitization of medical records ushered in a new era of big data to clinical science, and with it the possibility that data could be shared, to multiply insights beyond what investigators could abstract from paper records. The need to…

Machine Learning · Computer Science 2021-06-03 Ofer Mendelevitch , Michael D. Lesh

Training generative machine learning models to produce synthetic tabular data has become a popular approach for enhancing privacy in data sharing. As this typically involves processing sensitive personal information, releasing either the…

Cryptography and Security · Computer Science 2026-02-02 Georgi Ganev , Emiliano De Cristofaro

Training data is fundamental to the success of modern machine learning models, yet in high-stakes domains such as healthcare, the use of real-world training data is severely constrained by concerns over privacy leakage. A promising solution…

Artificial intelligence (AI) has the potential to transform healthcare, but it requires access to health data. Synthetic data that is generated through machine learning models trained on real data, offers a way to share data while…

Computers and Society · Computer Science 2025-08-13 Vibeke Binz Vallevik , Anne Kjersti C. Befring , Severin Elvatun , Jan Franz Nygaard

Acquiring large quantities of data and annotations is known to be effective for developing high-performing deep learning models, but is difficult and expensive to do in the healthcare context. Adding synthetic training data using generative…

Image and Video Processing · Electrical Eng. & Systems 2023-10-06 Menghan Yu , Sourabh Kulhare , Courosh Mehanian , Charles B Delahunt , Daniel E Shea , Zohreh Laverriere , Ishan Shah , Matthew P Horning

Recent advancements in generative AI have made it possible to create synthetic datasets that can be as accurate as real-world data for training AI models, powering statistical insights, and fostering collaboration with sensitive datasets…

Machine Learning · Computer Science 2025-01-08 Amy Steier , Lipika Ramaswamy , Andre Manoel , Alexa Haushalter

Sharing medical data for machine learning model training purposes is often impossible due to the risk of disclosing identifying information about individual patients. Synthetic data produced by generative artificial intelligence (genAI)…

Machine Learning · Computer Science 2026-02-12 Rustam Zhumagambetov , Niklas Giesa , Sebastian D. Boie , Stefan Haufe

Institutions collect massive learning traces but they may not disclose it for privacy issues. Synthetic data generation opens new opportunities for research in education. In this paper we present a generative model for educational data that…

Computers and Society · Computer Science 2022-07-09 Jill-Jênn Vie , Tomas Rigaux , Sein Minn

Synthetic data has been advertised as a silver-bullet solution to privacy-preserving data publishing that addresses the shortcomings of traditional anonymisation techniques. The promise is that synthetic data drawn from generative models…

Machine Learning · Computer Science 2022-01-25 Theresa Stadler , Bristena Oprisanu , Carmela Troncoso

Synthetic data has been considered a better privacy-preserving alternative to traditionally sanitized data across various applications. However, a recent article challenges this notion, stating that synthetic data does not provide a better…

Cryptography and Security · Computer Science 2025-07-28 Fatima Jahan Sarmin , Atiquer Rahman Sarkar , Yang Wang , Noman Mohammed

Recent advances in deep generative models have greatly expanded the potential to create realistic synthetic health datasets. These synthetic datasets aim to preserve the characteristics, patterns, and overall scientific conclusions derived…

Machine Learning · Computer Science 2024-07-04 Jennifer A Bartell , Sander Boisen Valentin , Anders Krogh , Henning Langberg , Martin Bøgsted

Preservation of private user data is of paramount importance for high Quality of Experience (QoE) and acceptability, particularly with services treating sensitive data, such as IT-based health services. Whereas anonymization techniques were…

Machine Learning · Computer Science 2024-03-04 Navid Ashrafi , Vera Schmitt , Robert P. Spang , Sebastian Möller , Jan-Niklas Voigt-Antons

Deep generative models and synthetic medical data have shown significant promise in addressing key challenges in healthcare, such as privacy concerns, data bias, and the scarcity of realistic datasets. While research in this area has grown…

Machine Learning · Computer Science 2025-02-05 Krishan Agyakari Raja Babu , Supriti Mulay , Om Prabhu , Mohanasankar Sivaprakasam

Sharing data can often enable compelling applications and analytics. However, more often than not, valuable datasets contain information of a sensitive nature, and thus, sharing them can endanger the privacy of users and organizations. A…

Cryptography and Security · Computer Science 2024-02-28 Emiliano De Cristofaro

Privacy-preserving synthetic data offers a promising solution to harness segregated data in high-stakes domains where information is compartmentalized for regulatory, privacy, or institutional reasons. This survey provides a comprehensive…

Cryptography and Security · Computer Science 2025-03-28 Viktor Schlegel , Anil A Bharath , Zilong Zhao , Kevin Yee

Unstructured textual data are at the heart of health systems: liaison letters between doctors, operating reports, coding of procedures according to the ICD-10 standard, etc. The details included in these documents make it possible to get to…

Cryptography and Security · Computer Science 2023-10-09 Yakini Tchouka , Jean-François Couchot , Maxime Coulmeau , David Laiymani , Philippe Selles , Azzedine Rahmani

The clinical time-series setting poses a unique combination of challenges to data modeling and sharing. Due to the high dimensionality of clinical time series, adequate de-identification to preserve privacy while retaining data utility is…

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