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3D-Polarized Light Imaging (3D-PLI) is a neuroimaging technique used to study the structural connectivity of the human brain at the meso- and microscale. In 3D-PLI, the complex nerve fiber architecture of the brain is characterized by 3D…

Computational Physics · Physics 2020-12-21 Felix Matuschke , Kévin Ginsburger , Cyril Poupon , Katrin Amunts , Markus Axer

Understanding the cortical organization of the human brain requires interpretable descriptors for distinct structural and functional imaging data. 3D polarized light imaging (3D-PLI) is an imaging modality for visualizing fiber architecture…

Computer Vision and Pattern Recognition · Computer Science 2024-09-04 Alexander Oberstrass , Jordan DeKraker , Nicola Palomero-Gallagher , Sascha E. A. Muenzing , Alan C. Evans , Markus Axer , Katrin Amunts , Timo Dickscheid

For developing a detailed network model of the brain based on image reconstructions, it is necessary to spatially resolve crossing nerve fibers. The accuracy hereby depends on many factors, including the spatial resolution of the imaging…

The method 3D polarised light imaging (3D-PLI) measures the birefringence of histological brain sections to determine the spatial course of nerve fibres (myelinated axons). While the in-plane fibre directions can be determined with high…

Biological Physics · Physics 2022-04-12 Miriam Menzel , Jan A. Reuter , David Gräßel , Irene Costantini , Katrin Amunts , Markus Axer

Mapping the intricate network of nerve fibers is crucial for understanding brain function. Three-Dimensional Polarized Light Imaging (3D-PLI) and Computational Scattered Light Imaging (ComSLI) map dense nerve fibers in brain sections with…

Medical Physics · Physics 2025-06-03 Franca auf der Heiden , Markus Axer , Katrin Amunts , Miriam Menzel

Three-dimensional Polarized Light Imaging (3D-PLI) is a promising technique to reconstruct the nerve fiber architecture of human post-mortem brains from birefringence measurements of histological brain sections with micrometer resolution.…

Medical Physics · Physics 2017-03-17 Miriam Menzel , Markus Axer , Hans De Raedt , Kristel Michielsen

3D reconstruction of the fiber connectivity of the rat brain at microscopic scale enables gaining detailed insight about the complex structural organization of the brain. We introduce a new method for registration and 3D reconstruction of…

Computer Vision and Pattern Recognition · Computer Science 2018-07-31 Sharib Ali , Martin Schober , Philipp Schlöme , Katrin Amunts , Markus Axer , Karl Rohr

Scattered Light Imaging (SLI) is a novel approach for microscopically revealing the fibre architecture of unstained brain sections. The measurements are obtained by illuminating brain sections from different angles and measuring the…

Image and Video Processing · Electrical Eng. & Systems 2022-04-13 Esteban Vaca , Miriam Menzel , Katrin Amunts , Markus Axer , Timo Dickscheid

Visual perception relies on inference of 3D scene properties such as shape, pose, and lighting. To understand how visual sensory neurons enable robust perception, it is crucial to characterize their selectivity to such physically…

Computer Vision and Pattern Recognition · Computer Science 2025-10-16 Pavithra Elumalai , Mohammad Bashiri , Goirik Chakrabarty , Suhas Shrinivasan , Fabian H. Sinz

The correct reconstruction of individual (crossing) nerve fibers is a prerequisite when constructing a detailed network model of the brain. The recently developed technique Scattered Light Imaging (SLI) allows the reconstruction of crossing…

Biological Physics · Physics 2021-11-30 Miriam Menzel , Marouan Ritzkowski , Jan André Reuter , David Gräßel , Katrin Amunts , Markus Axer

This paper introduces a novel self-supervised learning framework for enhancing 3D perception in autonomous driving scenes. Specifically, our approach, namely NCLR, focuses on 2D-3D neural calibration, a novel pretext task that estimates the…

Computer Vision and Pattern Recognition · Computer Science 2025-08-21 Yifan Zhang , Junhui Hou , Siyu Ren , Jinjian Wu , Yixuan Yuan , Guangming Shi

Comprehensive assessment of the various aspects of the brain's microstructure requires the use of complementary imaging techniques. This includes measuring the spatial distribution of cell bodies (cytoarchitecture) and nerve fibers…

Deep convolutional neural networks are powerful tools for learning visual representations from images. However, designing efficient deep architectures to analyse volumetric medical images remains challenging. This work investigates…

Computer Vision and Pattern Recognition · Computer Science 2017-07-10 Wenqi Li , Guotai Wang , Lucas Fidon , Sebastien Ourselin , M. Jorge Cardoso , Tom Vercauteren

Current 3D semi-supervised segmentation methods face significant challenges such as limited consideration of contextual information and the inability to generate reliable pseudo-labels for effective unsupervised data use. To address these…

Computer Vision and Pattern Recognition · Computer Science 2023-11-22 Sanaz Karimijafarbigloo , Reza Azad , Yury Velichko , Ulas Bagci , Dorit Merhof

Learning from 3D protein structures has gained wide interest in protein modeling and structural bioinformatics. Unfortunately, the number of available structures is orders of magnitude lower than the training data sizes commonly used in…

Biomolecules · Quantitative Biology 2022-06-01 Pedro Hermosilla , Timo Ropinski

Self-supervised deep learning has accelerated 2D natural image analysis but remains difficult to translate into 3D MRI, where data are scarce and pre-trained 2D backbones cannot capture volumetric context. We present a…

Computer Vision and Pattern Recognition · Computer Science 2025-07-30 Liam Chalcroft , Jenny Crinion , Cathy J. Price , John Ashburner

Constructing 3D structures from serial section data is a long standing problem in microscopy. The structure of a fiber reinforced composite material can be reconstructed using a tracking-by-detection model. Tracking-by-detection algorithms…

Computer Vision and Pattern Recognition · Computer Science 2018-05-28 Hongkai Yu , Dazhou Guo , Zhipeng Yan , Wei Liu , Jeff Simmons , Craig P. Przybyla , Song Wang

In many laboratories, conventional bright-field transmission microscopes are available to study the structure and organization principles of fibrous tissue samples, but they usually provide only 2D information. To access the third…

Self-supervised learning (SSL) has advanced medical image analysis be enabling learning form large unlabelled data. However, in brain magnetic resonance imaging (MRI), most 3D models remain specialized for either segmentation of…

Computer Vision and Pattern Recognition · Computer Science 2026-05-19 Amy Makawana , Abhijeet Parida , Marius George Linguraru , Julia Ive , Syed Muhammad Anwar

This paper demonstrates a self-supervised framework for learning voxel-wise coarse-to-fine representations tailored for dense downstream tasks. Our approach stems from the observation that existing methods for hierarchical representation…

Computer Vision and Pattern Recognition · Computer Science 2024-05-28 Eytan Kats , Jochen G. Hirsch , Mattias P. Heinrich
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