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Recent advances in multimodal large language models enable new possibilities for image-based decision support. However, their reliability and operational trade-offs in neuroimaging remain insufficiently understood. We present a…

Computer Vision and Pattern Recognition · Computer Science 2026-03-27 Katarina Trojachanec Dineva , Stefan Andonov , Ilinka Ivanoska , Ivan Kitanovski , Sasho Gramatikov , Tamara Kostova , Monika Simjanoska Misheva , Kostadin Mishev

The interpretation of histopathology cases underlies many important diagnostic and treatment decisions in medicine. Notably, this process typically requires pathologists to integrate and summarize findings across multiple slides per case.…

Multi-modal Large Language Models (MLLMs) exhibit impressive problem-solving abilities in various domains, but their visual comprehension and abstract reasoning skills remain under-evaluated. To this end, we present PolyMATH, a challenging…

Artificial Intelligence · Computer Science 2026-05-12 Himanshu Gupta , Shreyas Verma , Ujjwala Anantheswaran , Kevin Scaria , Mihir Parmar , Swaroop Mishra , Chitta Baral

Computational pathology foundation models (CPathFMs) have emerged as a powerful approach for analyzing histopathological data, leveraging self-supervised learning to extract robust feature representations from unlabeled whole-slide images.…

Computer Vision and Pattern Recognition · Computer Science 2025-02-27 Dong Li , Guihong Wan , Xintao Wu , Xinyu Wu , Ajit J. Nirmal , Christine G. Lian , Peter K. Sorger , Yevgeniy R. Semenov , Chen Zhao

Pathological diagnosis is vital for determining disease characteristics, guiding treatment, and assessing prognosis, relying heavily on detailed, multi-scale analysis of high-resolution whole slide images (WSI). However, existing large…

Computer Vision and Pattern Recognition · Computer Science 2025-05-19 Shengxuming Zhang , Weihan Li , Tianhong Gao , Jiacong Hu , Haoming Luo , Xiuming Zhang , Jing Zhang , Mingli Song , Zunlei Feng

Multimodal large language models (MLLMs) have broadened the scope of AI applications. Existing automatic evaluation methodologies for MLLMs are mainly limited in evaluating queries without considering user experiences, inadequately…

The diagnosis of pathological images is often limited by expert availability and regional disparities, highlighting the importance of automated diagnosis using Vision-Language Models (VLMs). Traditional multimodal models typically emphasize…

Computer Vision and Pattern Recognition · Computer Science 2025-04-21 Jianyu Wu , Hao Yang , Xinhua Zeng , Guibing He , Zhiyu Chen , Zihui Li , Xiaochuan Zhang , Yangyang Ma , Run Fang , Yang Liu

Large Multimodal Models (LMMs) such as GPT-4V and LLaVA have shown remarkable capabilities in visual reasoning with common image styles. However, their robustness against diverse style shifts, crucial for practical applications, remains…

Computer Vision and Pattern Recognition · Computer Science 2023-12-07 Rizhao Cai , Zirui Song , Dayan Guan , Zhenhao Chen , Xing Luo , Chenyu Yi , Alex Kot

Multimodal LLMs (MLLMs) are capable of performing complex data analysis, visual question answering, generation, and reasoning tasks. However, their ability to analyze biometric data is relatively underexplored. In this work, we investigate…

Computer Vision and Pattern Recognition · Computer Science 2026-04-14 Ekta Gavas , Sudipta Banerjee , Chinmay Hegde , Nasir Memon

Multimodal Large Language Models (MLLMs) have shown strong performance in visual and audio understanding when evaluated in isolation. However, their ability to jointly reason over omni-modal (visual, audio, and textual) signals in long and…

With the rapid development of computational pathology, many AI-assisted diagnostic tasks have emerged. Cellular nuclei segmentation can segment various types of cells for downstream analysis, but it relies on predefined categories and lacks…

Computer Vision and Pattern Recognition · Computer Science 2025-03-03 Chunlin Zhong , Shuang Hao , Junhua Wu , Xiaona Chang , Jiwei Jiang , Xiu Nie , He Tang , Xiang Bai

Large language models (LLMs) have demonstrated impressive capabilities in natural language understanding and generation, but the quality bar for medical and clinical applications is high. Today, attempts to assess models' clinical knowledge…

In contrast to their remarkable performance on general knowledge QA, the true abilities of Large Language Models (LLMs) in tasks demanding deep, specialized reasoning, such as in protein biology, have yet to be thoroughly investigated.…

Quantitative Methods · Quantitative Biology 2025-12-30 Dingyi Rong , Zijian Chen , Qi Jia , Kaiwei Zhang , Haotian Lu , Guangtao Zhai , Ning Liu

To advance the evaluation of multimodal math reasoning in large multimodal models (LMMs), this paper introduces a novel benchmark, MM-MATH. MM-MATH consists of 5,929 open-ended middle school math problems with visual contexts, with…

Computation and Language · Computer Science 2024-07-03 Kai Sun , Yushi Bai , Ji Qi , Lei Hou , Juanzi Li

Large Language Models (LLMs) and Large Multimodal Models (LMMs) exhibit impressive problem-solving skills in many tasks and domains, but their ability in mathematical reasoning in visual contexts has not been systematically studied. To…

Computer Vision and Pattern Recognition · Computer Science 2024-01-23 Pan Lu , Hritik Bansal , Tony Xia , Jiacheng Liu , Chunyuan Li , Hannaneh Hajishirzi , Hao Cheng , Kai-Wei Chang , Michel Galley , Jianfeng Gao

Multi-modal large language models(MLLMs) have achieved remarkable progress and demonstrated powerful knowledge comprehension and reasoning abilities. However, the mastery of domain-specific knowledge, which is essential for evaluating the…

Computation and Language · Computer Science 2024-05-09 Zheqi He , Xinya Wu , Pengfei Zhou , Richeng Xuan , Guang Liu , Xi Yang , Qiannan Zhu , Hua Huang

Pathology is experiencing rapid digital transformation driven by whole-slide imaging and artificial intelligence (AI). While deep learning-based computational pathology has achieved notable success, traditional models primarily focus on…

Generating natural and meaningful responses to communicate with multi-modal human inputs is a fundamental capability of Large Vision-Language Models(LVLMs). While current open-source LVLMs demonstrate promising performance in simplified…

Computer Vision and Pattern Recognition · Computer Science 2024-10-30 Ziyu Liu , Tao Chu , Yuhang Zang , Xilin Wei , Xiaoyi Dong , Pan Zhang , Zijian Liang , Yuanjun Xiong , Yu Qiao , Dahua Lin , Jiaqi Wang

Large Vision-Language Models (LVLMs) have recently played a dominant role in multimodal vision-language learning. Despite the great success, it lacks a holistic evaluation of their efficacy. This paper presents a comprehensive evaluation of…

Computer Vision and Pattern Recognition · Computer Science 2023-06-16 Peng Xu , Wenqi Shao , Kaipeng Zhang , Peng Gao , Shuo Liu , Meng Lei , Fanqing Meng , Siyuan Huang , Yu Qiao , Ping Luo