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Any process in which competing solutions replicate with errors and numbers of their copies depend on their respective fitnesses is the evolutionary optimization process. As during carcinogenesis mutated genomes replicate according to their…

Populations and Evolution · Quantitative Biology 2009-12-15 B. Brutovsky , D. Horvath

Generative molecular design has moved from proof-of-concept to real-world applicability, as marked by the surge in very recent papers reporting experimental validation. Key challenges in explainability and sample efficiency present…

Biomolecules · Quantitative Biology 2024-03-05 Jeff Guo , Philippe Schwaller

This paper introduces a methodology designed to augment the inverse design optimization process in scenarios constrained by limited compute, through the strategic synergy of multi-fidelity evaluations, machine learning models, and…

Computational Engineering, Finance, and Science · Computer Science 2024-06-04 Luka Grbcic , Juliane Müller , Wibe Albert de Jong

The performance bottleneck of deep-learning-based recommender systems resides in their backbone Deep Neural Networks. By integrating Processing-In-Memory~(PIM) architectures, researchers can reduce data movement and enhance energy…

Hardware Architecture · Computer Science 2025-05-19 Feng Cheng , Tunhou Zhang , Junyao Zhang , Jonathan Hao-Cheng Ku , Yitu Wang , Xiaoxuan Yang , Hai , Li , Yiran Chen

We apply kernel mean embedding methods to sample-based stochastic optimization and control. Specifically, we use the reduced-set expansion method as a way to discard sampled scenarios. The effect of such constraint removal is improved…

Optimization and Control · Mathematics 2020-04-24 Jia-Jie Zhu , Moritz Diehl , Bernhard Schölkopf

Optimization strategies driven by machine learning, such as Bayesian optimization, are being explored across experimental sciences as an efficient alternative to traditional design of experiment. When combined with automated laboratory…

Optimization and Control · Mathematics 2022-10-18 Riley J. Hickman , Matteo Aldeghi , Florian Häse , Alán Aspuru-Guzik

Hyperledger Fabric (HLF) is a modular, permissioned blockchain widely adopted in enterprise settings. Enhancing its throughput and latency remains challenging, as optimization decisions made in one phase of the transaction lifecycle can…

Distributed, Parallel, and Cluster Computing · Computer Science 2026-05-01 Pavan Sollu , Aniruddha Mukherjee , Divya Pulivarthi , S. R. Eshwar , Gugan Thoppe , Kshitij Pratihast , Tittu Varghese , Hrishikesh Nashikkar , Yogesh Simmhan

This paper reports on continuing research into the modelling of an order picking process within a Crossdocking distribution centre using Simulation Optimisation. The aim of this project is to optimise a discrete event simulation model and…

Artificial Intelligence · Computer Science 2010-07-05 Adrian Adewunmi , Uwe Aickelin

As global attention on renewable and clean energy grows, the research and implementation of microgrids become paramount. This paper delves into the methodology of exploring the relationship between the operational and environmental costs of…

Artificial Intelligence · Computer Science 2023-10-04 Hongyi Duan , Qingyang Li , Yuchen Li , Jianan Zhang , Yuming Xie

Spiking Neural Networks (SNNs) are promising biologically plausible models of computation which utilize a spiking binary activation function similar to that of biological neurons. SNNs are well positioned to process spatiotemporal data, and…

Neural and Evolutionary Computing · Computer Science 2025-05-20 Boxun Xu , Richard Boone , Peng Li

We examine the problem of optimal design in the context of filtering multiple random walks. Specifically, we define the steady state E-optimal design criterion and show that the underlying optimization problem leads to a second order cone…

Applications · Statistics 2010-10-07 Harsh Singhal , George Michailidis

Plant breeding programs use data obtained from multi-environment selection experiments to produce improved varieties with the ultimate aim of maintaining high levels of genetic gain. Selection accuracy can be improved with the use of…

Methodology · Statistics 2026-05-13 Brian R Cullis , Alison B Smith , David GD Hughes , David Butler

Speculative decoding (SD) accelerates large language model inference by employing a faster draft model for generating multiple tokens, which are then verified in parallel by the larger target model, resulting in the text generated according…

To improve decision-making and planning efficiency in back-end centralized redundant supply chains, this paper proposes a decision model integrating deep learning with intelligent particle swarm optimization. A distributed node deployment…

Machine Learning · Computer Science 2025-11-04 Shiman Zhang , Jinghan Zhou , Zhoufan Yu , Ningai Leng

Bio-Inspired computing is the subset of Nature-Inspired computing. Job Shop Scheduling Problem is categorized under popular scheduling problems. In this research work, Bacterial Foraging Optimization was hybridized with Ant Colony…

Neural and Evolutionary Computing · Computer Science 2012-11-22 S. Narendhar , T. Amudha

At submicron manufacturing technology nodes, pro- cess variations affect circuit performance significantly. To counter these variations, engineers are reserving more timing margin to maintain yield, leading to an unaffordable overdesign.…

Hardware Architecture · Computer Science 2017-05-16 Li Zhang , Bing Li , Jinglan Liu , Yiyu Shi , Ulf Schlichtmann

The aim of this study is to give insights into the trajectory optimization w.r.t. energy consumption and recuperation for stacker cranes in a high-bay warehouse. Based on an analytical necessary optimality condition, a targeted numerical…

Optimization and Control · Mathematics 2026-02-05 R. Zöllner , F. Schuricht , T. Schmidt , W. Hofmann

The concept of concurrent material and structure optimization aims at alleviating the computational discovery of optimum microstructure configurations in multiphase hierarchical systems, whose macroscale behavior is governed by their…

Computational Physics · Physics 2022-04-15 Tarun Gangwar , Dominik Schillinger

Uncertainty quantification has become an efficient tool for uncertainty-aware prediction, but its power in yield-aware optimization has not been well explored from either theoretical or application perspectives. Yield optimization is a much…

Optimization and Control · Mathematics 2020-04-28 Chunfeng Cui , Kaikai Liu , Zheng Zhang

In today competitive business environment, efficient logistics are essential, especially in industries where timely delivery matters. This research aims to improve warehouse picking cycle time through simulation-based analysis, using a…

Systems and Control · Electrical Eng. & Systems 2025-11-13 Phattara Khumprom , Wanatchapong Kongkaew , Antoun Yaacoub , Nattakit Thanawitsatien