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Multiomics data fusion integrates diverse data modalities, ranging from transcriptomics to proteomics, to gain a comprehensive understanding of biological systems and enhance predictions on outcomes of interest related to disease phenotypes…

Quantitative Methods · Quantitative Biology 2023-08-04 Daisy Yi Ding , Xiaotao Shen , Michael Snyder , Robert Tibshirani

Clustering is an unsupervised machine learning methodology where unlabeled elements/objects are grouped together aiming to the construction of well-established clusters that their elements are classified according to their similarity. The…

Machine Learning · Statistics 2023-10-20 Dimitrios Saligkaras , Vasileios E. Papageorgiou

Federated learning and its application to medical image segmentation have recently become a popular research topic. This training paradigm suffers from statistical heterogeneity between participating institutions' local datasets, incurring…

Image and Video Processing · Electrical Eng. & Systems 2023-10-19 Matthis Manthe , Stefan Duffner , Carole Lartizien

Personalized medicine is the future of medical practice. In oncology, tumor heterogeneity assessment represents a pivotal step for effective treatment planning and prognosis prediction. Despite new procedures for DNA sequencing and…

Precision medicine fundamentally aims to establish causality between dysregulated biochemical mechanisms and cancer subtypes. Omics-based cancer subtyping has emerged as a revolutionary approach, as different level of omics records the…

Genomics · Quantitative Biology 2023-08-25 Ziwei Yang , Zheng Chen , Yasuko Matsubara , Yasushi Sakurai

Random Forests (RF) are among the most powerful and widely used predictive models for centralized tabular data, yet few methods exist to adapt them to the federated learning setting. Unlike most federated learning approaches, the…

Machine Learning · Statistics 2026-05-08 Rémi Khellaf , Erwan Scornet , Aurélien Bellet , Julie Josse

The goal of this paper is to provide a method, which is able to find categories of traffic scenarios automatically. The architecture consists of three main components: A microscopic traffic simulation, a clustering technique and a…

Signal Processing · Electrical Eng. & Systems 2020-04-08 Friedrich Kruber , Jonas Wurst , Eduardo Sánchez Morales , Samarjit Chakraborty , Michael Botsch

Clustering traditionally aims to reveal a natural grouping structure within unlabeled data. However, this structure may not always align with users' preferences. In this paper, we propose a personalized clustering method that explicitly…

Machine Learning · Computer Science 2025-05-28 Xiwen Geng , Suyun Zhao , Yixin Yu , Borui Peng , Pan Du , Hong Chen , Cuiping Li , Mengdie Wang

The integration of multi-omics data has emerged as a promising approach for gaining comprehensive insights into complex diseases such as cancer. This paper proposes a novel approach to identify cancer subtypes through the integration of…

Machine Learning · Computer Science 2023-12-06 Mark Peelen , Leila Bagheriye , Johan Kwisthout

Cluster analysis methods are used to identify homogeneous subgroups in a data set. In biomedical applications, one frequently applies cluster analysis in order to identify biologically interesting subgroups. In particular, one may wish to…

Methodology · Statistics 2016-09-23 Sheila Gaynor , Eric Bair

Cancer subtyping is crucial for understanding the nature of tumors and providing suitable therapy. However, existing labelling methods are medically controversial, and have driven the process of subtyping away from teaching signals.…

Machine Learning · Computer Science 2022-11-15 Zheng Chen , Lingwei Zhu , Ziwei Yang , Takashi Matsubara

In this paper, we investigate federated clustering (FedC) problem, that aims to accurately partition unlabeled data samples distributed over massive clients into finite clusters under the orchestration of a parameter server, meanwhile…

Distributed, Parallel, and Cluster Computing · Computer Science 2023-11-07 Yiwei Li , Shuai Wang , Chong-Yung Chi , Tony Q. S. Quek

Effective feature selection is essential for high-dimensional data analysis and machine learning. Unsupervised feature selection (UFS) aims to simultaneously cluster data and identify the most discriminative features. Most existing UFS…

Machine Learning · Statistics 2026-03-23 Feng Yu , MD Saifur Rahman Mazumder , Ying Su , Oscar Contreras Velasco

Random Forest (RF) is an ensemble supervised machine learning technique that was developed by Breiman over a decade ago. Compared with other ensemble techniques, it has proved its accuracy and superiority. Many researchers, however, believe…

Machine Learning · Computer Science 2015-03-18 Khaled Fawagreh , Mohamad Medhat Gaber , Eyad Elyan

Unsupervised classification called clustering is a process of organizing objects into groups whose members are similar in some way. Clustering of uncertain data objects is a challenge in spatial data bases. In this paper we use Probability…

Databases · Computer Science 2013-12-10 Ramachandra Rao Kurada

In recent years, the growing need to leverage sensitive data across institutions has led to increased attention on federated learning (FL), a decentralized machine learning paradigm that enables model training without sharing raw data.…

This project aims to break down large pathology images into small tiles and then cluster those tiles into distinct groups without the knowledge of true labels, our analysis shows how difficult certain aspects of clustering tumorous and…

Image and Video Processing · Electrical Eng. & Systems 2020-12-29 Mostafa Ibrahim , Kevin Bryson

Predictive marker patterns in imaging data are a means to quantify disease and progression, but their identification is challenging, if the underlying biology is poorly understood. Here, we present a method to identify predictive texture…

Computer Vision and Pattern Recognition · Computer Science 2020-02-11 Matthias Perkonigg , Daniel Sobotka , Ahmed Ba-Ssalamah , Georg Langs

Federated Learning (FL) is a machine learning paradigm that safeguards privacy by retaining client data on edge devices. However, optimizing FL in practice can be challenging due to the diverse and heterogeneous nature of the learning…

Machine Learning · Computer Science 2024-06-11 Yongxin Guo , Xiaoying Tang , Tao Lin

We herein introduce a new method of interpretable clustering that uses unsupervised binary trees. It is a three-stage procedure, the first stage of which entails a series of recursive binary splits to reduce the heterogeneity of the data…

Methodology · Statistics 2011-10-28 Ricardo Fraiman , Badih Ghattas , Marcela Svarc