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Federated Learning (FL) enables decentralized machine learning while preserving data privacy, making it ideal for sensitive applications where data cannot be shared. While FL has been widely studied in supervised contexts, its application…

Machine Learning · Computer Science 2026-01-09 Mirko Nardi , Lorenzo Valerio , Andrea Passarella

Precision medicine is a paradigm shift in healthcare relying heavily on genomics data. However, the complexity of biological interactions, the large number of genes as well as the lack of comparisons on the analysis of data, remain a…

Federated learning is generally used in tasks where labels are readily available (e.g., next word prediction). Relaxing this constraint requires design of unsupervised learning techniques that can support desirable properties for federated…

Machine Learning · Computer Science 2022-06-14 Ekdeep Singh Lubana , Chi Ian Tang , Fahim Kawsar , Robert P. Dick , Akhil Mathur

Clustering mixed-type data remains a major challenge in biomedical research to uncover clinically meaningful subgroups within heterogeneous patient populations. Most existing clustering methods impose restrictive assumptions like local…

Applications · Statistics 2026-04-23 Yueting Wang , Shu Wang , Jonathan G. Yabes , Chung-Chou H. Chang

Electronic medical records (EMRs) supports the development of machine learning algorithms for predicting disease incidence, patient response to treatment, and other healthcare events. But insofar most algorithms have been centralized,…

Machine Learning · Computer Science 2019-03-25 Li Huang , Dianbo Liu

Medical image classification plays a crucial role in computer-aided clinical diagnosis. While deep learning techniques have significantly enhanced efficiency and reduced costs, the privacy-sensitive nature of medical imaging data…

Computer Vision and Pattern Recognition · Computer Science 2024-07-04 Sufen Ren , Yule Hu , Shengchao Chen , Guanjun Wang

As machine learning models are increasingly deployed in sensitive application areas, the demand for interpretable and trustworthy decision-making has increased. Random Forests (RF), despite their widespread use and strong performance on…

Federated learning is a distributed machine learning technology, which realizes the balance between data privacy protection and data sharing computing. To protect data privacy, feder-ated learning learns shared models by locally executing…

Machine Learning · Computer Science 2023-06-26 Tianyu Zhao , Junping Du , Yingxia Shao , Zeli Guan

Identifying and making statistical inferences on differential treatment effects (commonly known as subgroup analysis in clinical research) is central to precision health. Subgroup analysis allows practitioners to pinpoint populations for…

Machine Learning · Statistics 2026-02-05 Zhongming Xie , Joseph Giorgio , Jingshen Wang

Survival analysis aims to predict the timing of future events across various fields, from medical outcomes to customer churn. However, the integration of clustering into survival analysis, particularly for precision medicine, remains…

Machine Learning · Computer Science 2024-05-28 Gabriel Buginga , Edmundo de Souza e Silva

A modification of the Random Forest algorithm for the categorization of traffic situations is introduced in this paper. The procedure yields an unsupervised machine learning method. The algorithm generates a proximity matrix which contains…

Signal Processing · Electrical Eng. & Systems 2020-04-08 Friedrich Kruber , Jonas Wurst , Michael Botsch

Due to the wider availability of modern electronic health records, patient care data is often being stored in the form of time-series. Clustering such time-series data is crucial for patient phenotyping, anticipating patients' prognoses by…

Medical Physics · Physics 2020-06-17 Changhee Lee , Mihaela van der Schaar

Clustering is a well-known unsupervised machine learning approach capable of automatically grouping discrete sets of instances with similar characteristics. Constrained clustering is a semi-supervised extension to this process that can be…

Machine Learning · Computer Science 2023-03-02 Germán González-Almagro , Daniel Peralta , Eli De Poorter , José-Ramón Cano , Salvador García

Cluster analysis methods seek to partition a data set into homogeneous subgroups. It is useful in a wide variety of applications, including document processing and modern genetics. Conventional clustering methods are unsupervised, meaning…

Methodology · Statistics 2014-07-11 Eric Bair

High-throughput omics profiling advancements have greatly enhanced cancer patient stratification. However, incomplete data in multi-omics integration presents a significant challenge, as traditional methods like sample exclusion or…

Genomics · Quantitative Biology 2024-01-17 Shihao Ma , Andy G. X. Zeng , Benjamin Haibe-Kains , Anna Goldenberg , John E Dick , Bo Wang

The discovery of disease subtypes is an essential step for developing precision medicine, and disease subtyping via omics data has become a popular approach. While promising, subtypes obtained from existing approaches are not necessarily…

Quantitative Methods · Quantitative Biology 2022-03-01 Lingsong Meng , Dorina Avram , George Tseng , Zhiguang Huo

For early breast cancer detection, regular screening with mammography imaging is recommended. Routinary examinations result in datasets with a predominant amount of negative samples. A potential solution to such class-imbalance is joining…

Computer Vision and Pattern Recognition · Computer Science 2023-01-09 Amelia Jiménez-Sánchez , Mickael Tardy , Miguel A. González Ballester , Diana Mateus , Gemma Piella

In diverse fields ranging from finance to omics, it is increasingly common that data is distributed and with multiple individual sources (referred to as ``clients'' in some studies). Integrating raw data, although powerful, is often not…

Methodology · Statistics 2022-11-08 Yuanxing Chen , Qingzhao Zhang , Shuangge Ma , Kuangnan Fang

Determining phenotypes of diseases can have considerable benefits for in-hospital patient care and to drug development. The structure of high dimensional data sets such as electronic health records are often represented through an embedding…

Random forests are considered a cornerstone in machine learning for their robustness and versatility. Despite these strengths, their conventional centralized training is ill-suited for the modern landscape of data that is often distributed,…

Machine Learning · Computer Science 2024-07-30 Penjan Antonio Eng Lim , Cheong Hee Park