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Anomaly detection in medical images is challenging due to limited annotations and a domain gap compared to natural images. Existing reconstruction methods often rely on frozen pre-trained encoders, which limits adaptation to domain-specific…

Computer Vision and Pattern Recognition · Computer Science 2025-08-28 Luhu Li , Bowen Lin , Mukhtiar Khan , Shujun Fu

Clinical diagnosis is a highly specialized discipline requiring both domain expertise and strict adherence to rigorous guidelines. While current AI-driven medical research predominantly focuses on knowledge graphs or natural text…

Machine Learning · Computer Science 2025-12-12 Haolin Li , Tianjie Dai , Zhe Chen , Siyuan Du , Jiangchao Yao , Ya Zhang , Yanfeng Wang

Medical anomaly detection is a critical research area aimed at recognizing abnormal images to aid in diagnosis.Most existing methods adopt synthetic anomalies and image restoration on normal samples to detect anomaly. The unlabeled data…

Image and Video Processing · Electrical Eng. & Systems 2024-05-22 Zerui Zhang , Zhichao Sun , Zelong Liu , Bo Du , Rui Yu , Zhou Zhao , Yongchao Xu

Deep learning based medical image diagnosis has shown great potential in clinical medicine. However, it often suffers two major difficulties in real-world applications: 1) only limited labels are available for model training, due to…

Computer Vision and Pattern Recognition · Computer Science 2020-08-26 Yifan Zhang , Ying Wei , Qingyao Wu , Peilin Zhao , Shuaicheng Niu , Junzhou Huang , Mingkui Tan

Pelvic diseases in women of reproductive age represent a major global health burden, with diagnosis frequently delayed due to high anatomical variability, complicating MRI interpretation. Existing AI approaches are largely disease-specific…

We focus on a specific use case in anomaly detection where the distribution of normal samples is supported by a lower-dimensional manifold. Here, regularized autoencoders provide a popular approach by learning the identity mapping on the…

Computer Vision and Pattern Recognition · Computer Science 2024-05-14 Alexander Bauer , Shinichi Nakajima , Klaus-Robert Müller

With the increasing incidence of neurodegenerative diseases such as Alzheimer's Disease (AD), there is a need for further research that enhances detection and monitoring of the diseases. We present MORPHADE (Morphological Autoencoders for…

Image and Video Processing · Electrical Eng. & Systems 2024-07-08 Mehmet Yigit Avci , Emily Chan , Veronika Zimmer , Daniel Rueckert , Benedikt Wiestler , Julia A. Schnabel , Cosmin I. Bercea

Radiography imaging protocols focus on particular body regions, therefore producing images of great similarity and yielding recurrent anatomical structures across patients. Exploiting this structured information could potentially ease the…

Image and Video Processing · Electrical Eng. & Systems 2024-03-14 Tiange Xiang , Yixiao Zhang , Yongyi Lu , Alan Yuille , Chaoyi Zhang , Weidong Cai , Zongwei Zhou

Diagnosis and treatment guidance are aided by detecting relevant biomarkers in medical images. Although supervised deep learning can perform accurate segmentation of pathological areas, it is limited by requiring a-priori definitions of…

In this study, a new Anomaly Detection (AD) approach for industrial and medical images is proposed. This method leverages the theoretical strengths of unsupervised learning and the data availability of both normal and abnormal classes.…

Computer Vision and Pattern Recognition · Computer Science 2024-01-24 Arnaud Bougaham , Valentin Delchevalerie , Mohammed El Adoui , Benoît Frénay

Unsupervised learning can leverage large-scale data sources without the need for annotations. In this context, deep learning-based autoencoders have shown great potential in detecting anomalies in medical images. However, especially…

Image and Video Processing · Electrical Eng. & Systems 2020-01-03 David Zimmerer , Simon Kohl , Jens Petersen , Fabian Isensee , Klaus Maier-Hein

We propose a completely unsupervised pixel-wise anomaly detection method for hyperspectral images. The proposed method consists of three steps called data preparation, reconstruction, and detection. In the data preparation step, we apply a…

Image and Video Processing · Electrical Eng. & Systems 2021-01-25 Sertac Arisoy , Nasser M. Nasrabadi , Koray Kayabol

Deep anomaly detection models using a supervised mode of learning usually work under a closed set assumption and suffer from overfitting to previously seen rare anomalies at training, which hinders their applicability in a real scenario. In…

Image and Video Processing · Electrical Eng. & Systems 2020-10-26 Behzad Bozorgtabar , Dwarikanath Mahapatra , Guillaume Vray , Jean-Philippe Thiran

Medical anomaly detection is a crucial yet challenging task aimed at recognizing abnormal images to assist in diagnosis. Due to the high-cost annotations of abnormal images, most methods utilize only known normal images during training and…

Computer Vision and Pattern Recognition · Computer Science 2023-03-21 Yu Cai , Hao Chen , Xin Yang , Yu Zhou , Kwang-Ting Cheng

Anomalies can be defined as any non-random structure which deviates from normality. Anomaly detection methods reported in the literature are numerous and diverse, as what is considered anomalous usually varies depending on particular…

Computer Vision and Pattern Recognition · Computer Science 2022-05-25 Matías Tailanian , Pablo Musé , Álvaro Pardo

Medical images are often used to detect and characterize pathology and disease; however, automatically identifying and segmenting pathology in medical images is challenging because the appearance of pathology across diseases varies widely.…

Image and Video Processing · Electrical Eng. & Systems 2020-02-19 Jacob C. Reinhold , Yufan He , Shizhong Han , Yunqiang Chen , Dashan Gao , Junghoon Lee , Jerry L. Prince , Aaron Carass

Computer-aided diagnosis for low-dose computed tomography (CT) based on deep learning has recently attracted attention as a first-line automatic testing tool because of its high accuracy and low radiation exposure. However, existing methods…

Image and Video Processing · Electrical Eng. & Systems 2022-06-28 Kyung-Su Kim , Seong Je Oh , Ju Hwan Lee , Myung Jin Chung

Data transformations (e.g. rotations, reflections, and cropping) play an important role in self-supervised learning. Typically, images are transformed into different views, and neural networks trained on tasks involving these views produce…

Machine Learning · Computer Science 2022-02-04 Chen Qiu , Timo Pfrommer , Marius Kloft , Stephan Mandt , Maja Rudolph

T2 hyperintensities in spinal cord MR images are crucial biomarkers for conditions such as degenerative cervical myelopathy. However, current clinical diagnoses primarily rely on manual evaluation. Deep learning methods have shown promise…

Image and Video Processing · Electrical Eng. & Systems 2025-03-18 Qi Zhang , Xiuyuan Chen , Ziyi He , Kun Wang , Lianming Wu , Hongxing Shen , Jianqi Sun

Lesion detection in brain Magnetic Resonance Images (MRIs) remains a challenging task. MRIs are typically read and interpreted by domain experts, which is a tedious and time-consuming process. Recently, unsupervised anomaly detection (UAD)…

Image and Video Processing · Electrical Eng. & Systems 2022-02-01 Marcel Bengs , Finn Behrendt , Max-Heinrich Laves , Julia Krüger , Roland Opfer , Alexander Schlaefer