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3D-printed microfluidic devices offer new ways to study fluid dynamics. We present the first clear visualization of vortex breakdown in a dividing T-junction flow. By individual control of the inflow and two outflows, we decouple the…

Fluid Dynamics · Physics 2018-06-29 San To Chan , Simon J. Haward , Amy Q. Shen

Three-dimensional, time-dependent direct simulations of step emulsification micro-devices highlight two essential mechanisms for droplet formation: first, the onset of an adverse pressure gradient driving a back-flow of the continuous phase…

Computational Physics · Physics 2020-06-22 Andrea Montessori , Marco Lauricella , Sauro Succi , Elad Stolovicki , David A. Weitz

A generative model capable of sampling realistic molecules with desired properties could accelerate chemical discovery across a wide range of applications. Toward this goal, significant effort has focused on developing models that jointly…

Machine Learning · Computer Science 2025-08-19 Ian Dunn , David R. Koes

We used volume-of-fluid (VOF) method to perform three-dimensional numerical simulations of droplet formation of Newtonian fluids in microfluidic T-junction devices. To evaluate the performance of the VOF method we examined the regimes of…

Fluid Dynamics · Physics 2017-04-26 Mehdi Nekouei , Siva A. Vanapalli

Droplets form a cornerstone of the spatiotemporal organization of biomolecules in cells. These droplets are controlled using physical processes like chemical reactions and imposed gradients, which are costly to simulate using traditional…

Soft Condensed Matter · Physics 2022-06-23 Ajinkya Kulkarni , Estefania Vidal-Henriquez , David Zwicker

The simulation of high-energy physics collision events is a key element for data analysis at present and future particle accelerators. The comparison of simulation predictions to data allows looking for rare deviations that can be due to…

High Energy Physics - Experiment · Physics 2024-07-16 Francesco Vaselli , Filippo Cattafesta , Patrick Asenov , Andrea Rizzi

The increasing use of microfluidics in industrial, biomedical, and clinical applications requires a more and more precise control of the microfluidic flows and suspended particles or cells. This leads to higher demands in three-dimensional…

Fluid Dynamics · Physics 2020-11-10 Massimiliano Rossi , Rune Barnkob

The production of monodisperse particles or droplets is a longstanding issue across various fields, from aerosol science to inkjet printing. In bioengineering, submillimeter cell laden hydrogel capsules have proven valuable for developing…

Fluid Dynamics · Physics 2025-03-28 Lucas Suire , Anirban Jana , Pierre Nassoy , Amaury Badon

Mixing is one of the basic functions which automated lab-on-chips require for the effective management of liquid samples. In this paper we report on the working principle, design, fabrication and experimental characterization of a…

Soft Condensed Matter · Physics 2010-12-14 M. Campisi , D. Accoto , F. Damiani , P. Dario

Given the ever-increasing advances of digital microfluidic biochips and their application in a wide range of areas including bio-chemistry experiments, diagnostics, and monitoring purposes like air and water quality control and etc.,…

Emerging Technologies · Computer Science 2020-01-01 Alireza Abdoli

We have developed an original setup using microfluidic tools allowing one to produce continuously monodisperse microreactors ($\approx 100$ nL), and to control their temperatures as they flow in the microdevice. With a specific…

Soft Condensed Matter · Physics 2009-11-11 Philippe Laval , Jean-Baptiste Salmon , Mathieu Joanicot

We describe an approach for modeling fluid concentration profiles in grid-based microfluidic chips for fluid mixing. This approach provides an algorithm that predicts fluid concentrations at the chip outlets. Our algorithm significantly…

Computational Engineering, Finance, and Science · Computer Science 2019-11-19 Huong Luu , Marek Chrobak

We present a one-dimensional shear-force-driven droplet formation model with a flux-based error estimator. The model is derived using asymptotic expansion and a front-tracking method to simulate the droplet interface. The model is then…

Numerical Analysis · Mathematics 2026-05-25 Darsh Nathawani , Matthew Knepley

Droplet breakup is an important phenomenon in the field of microfluidics to generate daughter droplets. In this work, a novel breakup regime in the widely studied T-junction geometry is reported, where the pinch-off occurs laterally in the…

Liquid-droplet coalescence and the mergers of liquid lenses are problems of great practical and theoretical interest in fluid dynamics and the statistical mechanics of multi-phase flows. During such mergers, there is an interesting and…

Fluid Dynamics · Physics 2024-10-08 Vasanth Kumar Babu , Nadia Bihari Padhan , Rahul Pandit

As one of the most popular and sought-after generative models in the recent years, diffusion models have sparked the interests of many researchers and steadily shown excellent advantage in various generative tasks such as image synthesis,…

Computer Vision and Pattern Recognition · Computer Science 2024-10-17 Zhiyuan Ma , Yuzhu Zhang , Guoli Jia , Liangliang Zhao , Yichao Ma , Mingjie Ma , Gaofeng Liu , Kaiyan Zhang , Jianjun Li , Bowen Zhou

This study presents a three-dimensional transient computational fluid dynamics simulation of droplet generation in a flow-focusing microfluidic device using the Coupled Level Set and Volume of Fluid method for interface capturing. We…

Fluid Dynamics · Physics 2025-07-17 Manohar Jammula , Somasekhara Goud Sontti

The efficient mixing of fluids is key in many applications, such as chemical reactions and nanoparticle precipitation. Detailed experimental measurements of the mixing dynamics are however difficult to obtain, and so predictive numerical…

Fluid Dynamics · Physics 2017-11-21 Tobias Schikarski , Wolfgang Peukert , Marc Avila

We present a mesoscale representation of near-contact interactions between colliding droplets which permits to reach up to the scale of full microfluidic devices, where such droplets are produced. The method is demonstrated for the case of…

Computational Physics · Physics 2020-06-23 Andrea Montessori , Marco Lauricella , Adriano Tiribocchi , Sauro Succi

The use of microscopic discrete fluid volumes (i.e., droplets) as microreactors for digital microfluidic applications often requires mixing enhancement and control within droplets. In this work, we consider a translating spherical liquid…

Fluid Dynamics · Physics 2008-09-23 R. Chabreyrie , D. Vainchtein , C. Chandre , P. Singh , N. Aubry