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Sample preparation is an indispensable component of almost all biochemical protocols, and it involves, among others, making dilutions and mixtures of fluids in certain ratios. Recent microfluidic technologies offer suitable platforms for…

Emerging Technologies · Computer Science 2019-01-03 Sudip Poddar , Robert Wille , Hafizur Rahaman , Bhargab B. Bhattacharya

Microfluidic devices are gaining attention for their small size and ability to handle tiny fluid volumes. Mixing fluids efficiently at this scale, known as micromixing, is crucial. This article builds upon previous research by introducing a…

Droplet-based microfluidics has emerged as a powerful technology for the miniaturization and automation of biochemical assays. The replacement of surfactants by nanoparticles as interfacial stabilizers has gained increasing interest.…

Soft Condensed Matter · Physics 2019-06-21 Laura Andreina Chacon Orellana , Jean-Christophe Baret

Droplet formation happens in finite time due to the surface tension force. The linear stability analysis is useful to estimate droplet size but fails to approximate droplet shape. This is due to a highly non-linear flow description near the…

Fluid Dynamics · Physics 2023-07-04 Darsh Nathawani , Matthew Knepley

We have developed a coupled level set and volume of fluid-based computational fluid dynamics model to analyze the droplet formation mechanism in a square flow-focusing microchannel. We demonstrate a flexible manipulation of droplet…

Fluid Dynamics · Physics 2025-10-09 Somasekhara Goud Sontti , Arnab Atta

Droplet-based microfluidics turned out to be an efficient and adjustable platform for digital analysis, encapsulation of cells, drug formulation, and polymerase chain reaction. Typically, for most biomedical applications, the handling of…

Soft Condensed Matter · Physics 2018-01-30 Enrico Chiarello , Anupam Gupta , Giampaolo Mistura , Mauro Sbragaglia , Matteo Pierno

Chemical bioreactions play a significant role in many of the microfluidic devices, and their applications in biomedical science have seen substantial growth. Given that effective mixing is vital for initiating biochemical reactions in many…

Fluid Dynamics · Physics 2024-02-13 Ali Kheirkhah Barzoki

Integrated micro-nanochannel networks in fluidic devices are desirable in a number of applications ranging from self-healing/cooling materials to bioengineering. The conventional micro-manufacturing techniques are capable of either…

Materials Science · Physics 2017-04-10 Prasoon Kumar , Prasanna S Gandhi , Mainak Majumder

The generation of microdroplets via segmentation in microfluidic devices is of interest in many applications, from biochemical to pharmaceutical. This technique permits indeed much higher control on the droplet size, uniformity and…

Fluid Dynamics · Physics 2026-01-15 Alessio Innocenti , Andrea Poggi , Simone Camarri , Maria Vittoria Salvetti

This work describes a new microfluidic device developed for rapid screening of solubility diagrams. In several parallel channels, hundreds of nanoliter-volume droplets of a given solution are first stored with a gradual variation in the…

Soft Condensed Matter · Physics 2007-05-23 P. Laval , N. Lisai , J. -B. Salmon , M. Joanicot

In this article, we have developed a computational model to determine the droplet formation regime and its transition in a square microfluidic flow-focusing device that eventually dictate the droplet shape, size, and its formation…

Fluid Dynamics · Physics 2025-10-28 Somasekhara Goud Sontti , Arnab Atta

Compound droplets can be used in substance encapsulation and material compartmentalization to achieve a precise control over the relevant processes in many applications, such as bioanalysis, pharmaceutical manufacturing, and material…

Fluid Dynamics · Physics 2018-02-22 Zhizhao Che , Yit Fatt Yap , Tianyou Wang

Here, we describe a simple and unique architecture of a microfluidic mixer that can mix two streams (Water and Fluorescein Isothiocyanate (FITC) buffer) with 30% efficiency. The overall mixing in this design is dominated by 1D diffusion,…

Medical Physics · Physics 2024-02-26 M. Rashed Khan , Taliman Afroz , Caleb Shaw

The mechanical properties of biological fluids can serve as early indicators of disease, offering valuable insights into complex physiological and pathological processes. However, the existing technologies can hardly support high throughput…

Optics · Physics 2025-09-18 Zhonghao Li , Zhihan Cai , Chaoyang Gong

Microfluidic devices have been the subject of considerable attention in recent years. The development of novel microfluidic devices, their evaluation, and their validation requires simulations. While common methods based on Computational…

Fluid Dynamics · Physics 2024-11-05 Maria Emmerich , Florina Costamoling , Robert Wille

Droplet microfluidics offers a versatile platform for analyzing liquid samples. Despite its potential, there is a lack of techniques that allow to reliably probe individual circulating droplets. The prospect of combining droplet…

Quantitative Methods · Quantitative Biology 2024-03-08 Marc Sulliger , Jaime Ortega Arroyo , Romain Quidant

Creating realistic droplet simulations and animations has long been a formidable challenge for researchers and developers due to the inherent complexity of fluid dynamics. Achieving lifelike droplet splash simulations while managing…

Fluid Dynamics · Physics 2024-11-26 Hossein Keshtkar , Nadine Aburumman

Droplet microfluidics, in which micro-droplets serve as individual reactors, has enabled a wide range of high-throughput biochemical processes. Unlike solid wells typically used in current biochemical assays, droplets are subject to…

Soft Condensed Matter · Physics 2022-06-03 Ya Gai , Andrea Montessori , Sauro Succi , Sindy K. Y. Tang

Block copolymers often create droplets when placed on a substrate. Such nanostructured droplets can be arranged into regular microstructured arrays, thereby forming hierarchically organized materials that can be used in microelectronics,…

Soft Condensed Matter · Physics 2026-05-04 Artem Petrov , Guillermo A. Hernández-Mendoza , Alfredo Alexander-Katz

We combine theory, numerical simulation and experiments to investigate the breakup of two identical droplets entering a Y-junction with controlled spatial offset by which the second droplet trails the first. Based on fully resolved 3D…

Fluid Dynamics · Physics 2020-08-04 Simon Schütz , Jian Wei Khor , Sindy K. Y. Tang , Tobias M. Schneider