Related papers: A Three-dimensional tumor growth model and its bou…
Reliably predicting the future spread of brain tumors using imaging data and on a subject-specific basis requires quantifying uncertainties in data, biophysical models of tumor growth, and spatial heterogeneity of tumor and host tissue.…
In this study, we model avascular tumour growth in epithelial tissue. This can help us to get a macroscopic view of the interaction between the tumour with its surrounding microenvironment and the physical changes within the tumour…
Tumor growth beyond a critical size relies on the development of a functional vascular network, which ensures adequate oxygen and nutrient supply. In this work, we present a modeling framework based on an optimization-based 3D-1D coupling…
In this paper we study a free boundary problem modeling the growth of solid tumor spheroid. It consists of two elliptic equations describing nutrient diffusion and pressure distribution within tumor, respectively. The new feature is that…
Turbulent flows driven by a vertically invariant body force were proven to become exactly two-dimensional above a critical rotation rate, using upper bound theory. This transition in dimensionality of a turbulent flow has key consequences…
This paper concerns the dynamic stability of the steady 3-D wave structure of a planar normal shock front intersecting perpendicularly to a planar solid wall for unsteady potential flows. The stability problem can be formulated as a free…
We introduce here a new diffuse interface thermodynamically consistent non-isothermal model for tumor growth in presence of a nutrient in a domain $\Omega \subset \mathbb{R}^3$. In particular our system describes the growth of a tumor…
In the present article we demonstrate a new hybrid model of tumor growth. Our model is stochastic by tumor population development and strongly deterministic in cell motility dynamics and spatial propagation. In addition, it has excellent…
We analyze the stability properties of the so-called triple deck model, a classical refinement of the Prandtl equation to describe boundary layer separation. Combining the methodology introduced in [2], based on complex analysis tools, and…
Accurately modeling the spatiotemporal evolution of tumor morphology from baseline imaging is a pre-requisite for developing digital twin frameworks that can simulate disease progression and treatment response. Most existing approaches…
In this paper, we consider the travel time tomography problem for conformal metrics on a bounded domain, which seeks to determine the conformal factor of the metric from the lengths of geodesics joining boundary points. We establish forward…
Mechanical models of tumor growth based on a porous medium approach have been attracting a lot of interest both analytically and numerically. In this paper, we study the stability properties of a finite difference scheme for a model where…
In this work, we present a coupled 3D-1D model of solid tumor growth within a dynamically changing vascular network to facilitate realistic simulations of angiogenesis. Additionally, the model includes erosion of the extracellular matrix,…
We study gravitationally unstable, transient, diffusive boundary layers in porous media using modal and nonmodal stability methods. Using nonmodal stability theory, we demonstrate that both the onset of linear instabilities and the shape of…
In this thesis I studied the Symanzik's method for the introduction of the boundary in a field theory and, specifically, I applied this method to three Topological Field Theories of the Shwartz type: the non-abelian Chern-Simons model, the…
Motivated by experimental observations, we develop a mathematical model of chemotactically directed tumor growth. We present an analytical study of the model as well as a numerical one. The mathematical analysis shows that: (i) tumor cell…
The work presents a study of the non-linear mathematical model of tumor growth, proposed by Kolev and Zubik-Kowal (2011). The model is described by a system composed of four partial differential equations that represent the evolution of the…
In medical imaging, segmentation and localization of spinal tumors in three-dimensional (3D) space pose significant computational challenges, primarily stemming from limited data availability. In response, this study introduces a novel data…
Motivated by the incompressible limit of a cell density model, we propose a free boundary tumor growth model where the pressure satisfies an obstacle problem on an evolving domain $\Omega(t)$, and the coincidence set $\Lambda(t)$ captures…
We study nonparametric distance-based (isotropic) local polynomial methods for estimating the boundary average treatment effect curve, a causal functional that captures treatment effect heterogeneity in boundary discontinuity designs. We…