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The rapid development of spatial transcriptomics (ST) technologies is revolutionizing our understanding of the spatial organization of biological tissues. Current ST methods, categorized into next-generation sequencing-based (seq-based) and…

Machine Learning · Computer Science 2024-07-19 Xiaoyu Li , Fangfang Zhu , Wenwen Min

Discrete diffusion models are a class of generative models that construct sequences by progressively denoising samples from a categorical noise distribution. Beyond their rapidly growing ability to generate coherent natural language, these…

Computation and Language · Computer Science 2025-12-11 Michael Cardei , Jacob K Christopher , Thomas Hartvigsen , Bhavya Kailkhura , Ferdinando Fioretto

In recent years, diffusion models have gained popularity for their ability to generate higher-quality images in comparison to GAN models. However, like any other large generative models, these models require a huge amount of data,…

Computer Vision and Pattern Recognition · Computer Science 2023-12-21 Rajesh Shrestha , Bowen Xie

Diffusion model, a new generative modelling paradigm, has achieved great success in image, audio, and video generation. However, considering the discrete categorical nature of text, it is not trivial to extend continuous diffusion models to…

Computation and Language · Computer Science 2023-05-23 Hongyi Yuan , Zheng Yuan , Chuanqi Tan , Fei Huang , Songfang Huang

Single-cell RNA sequencing (scRNA-seq) provides unprecedented insights into cellular heterogeneity, enabling detailed analysis of complex biological systems at single-cell resolution. However, the high dimensionality and technical noise…

Genomics · Quantitative Biology 2025-09-04 Hojjat Torabi Goudarzi , Maziyar Baran Pouyan

Conditional diffusion models serve as the foundation of modern image synthesis and find extensive application in fields like computational biology and reinforcement learning. In these applications, conditional diffusion models incorporate…

Machine Learning · Computer Science 2024-03-19 Hengyu Fu , Zhuoran Yang , Mengdi Wang , Minshuo Chen

Diffusion-based foundation models have recently garnered much attention in the field of generative modeling due to their ability to generate images of high quality and fidelity. Although not straightforward, their recent application to the…

Computer Vision and Pattern Recognition · Computer Science 2025-09-30 Nikos Kostagiolas , Pantelis Georgiades , Yannis Panagakis , Mihalis A. Nicolaou

In recent years, the advances in single-cell RNA-seq techniques have enabled us to perform large-scale transcriptomic profiling at single-cell resolution in a high-throughput manner. Unsupervised learning such as data clustering has become…

Genomics · Quantitative Biology 2020-01-07 Shixiong Zhang , Xiangtao Li , Qiuzhen Lin , Ka-Chun Wong

Graph is a prevalent discrete data structure, whose generation has wide applications such as drug discovery and circuit design. Diffusion generative models, as an emerging research focus, have been applied to graph generation tasks.…

Machine Learning · Computer Science 2024-11-05 Zhe Xu , Ruizhong Qiu , Yuzhong Chen , Huiyuan Chen , Xiran Fan , Menghai Pan , Zhichen Zeng , Mahashweta Das , Hanghang Tong

Generating high-resolution images with generative models has recently been made widely accessible by leveraging diffusion models pre-trained on large-scale datasets. Various techniques, such as MultiDiffusion and SyncDiffusion, have further…

Computer Vision and Pattern Recognition · Computer Science 2025-01-08 Stanislav Frolov , Brian B. Moser , Andreas Dengel

Single-cell RNA sequencing provides tremendous insights to understand biological systems. However, the noise from dropout can corrupt the downstream biological analysis. Hence, it is desirable to impute the dropouts accurately. In this…

Quantitative Methods · Quantitative Biology 2020-08-11 Kexin Huang

Diffusion models have achieved state-of-the-art results on many modalities including images, speech, and video. However, existing models are not tailored to support remote sensing data, which is widely used in important applications…

Computer Vision and Pattern Recognition · Computer Science 2024-05-28 Samar Khanna , Patrick Liu , Linqi Zhou , Chenlin Meng , Robin Rombach , Marshall Burke , David Lobell , Stefano Ermon

We present SinDiffusion, leveraging denoising diffusion models to capture internal distribution of patches from a single natural image. SinDiffusion significantly improves the quality and diversity of generated samples compared with…

Computer Vision and Pattern Recognition · Computer Science 2022-11-23 Weilun Wang , Jianmin Bao , Wengang Zhou , Dongdong Chen , Dong Chen , Lu Yuan , Houqiang Li

Generating synthetic datasets for training face recognition models is challenging because dataset generation entails more than creating high fidelity images. It involves generating multiple images of same subjects under different factors…

Computer Vision and Pattern Recognition · Computer Science 2023-04-17 Minchul Kim , Feng Liu , Anil Jain , Xiaoming Liu

Training data has been proven to be one of the most critical components in training generative AI. However, obtaining high-quality data remains challenging, with data privacy issues presenting a significant hurdle. To address the need for…

Computation and Language · Computer Science 2025-06-18 Jia-Chen Zhang , Zheng Zhou , Yu-Jie Xiong , Chun-Ming Xia , Fei Dai

Diffusion models have become a new generative paradigm for text generation. Considering the discrete categorical nature of text, in this paper, we propose GlyphDiffusion, a novel diffusion approach for text generation via text-guided image…

Computation and Language · Computer Science 2023-05-09 Junyi Li , Wayne Xin Zhao , Jian-Yun Nie , Ji-Rong Wen

We demonstrate how conditional generation from diffusion models can be used to tackle a variety of realistic tasks in the production of music in 44.1kHz stereo audio with sampling-time guidance. The scenarios we consider include…

Sound · Computer Science 2023-12-06 Mark Levy , Bruno Di Giorgi , Floris Weers , Angelos Katharopoulos , Tom Nickson

Survival analysis is a cornerstone of clinical research by modeling time-to-event outcomes such as metastasis, disease relapse, or patient death. Unlike standard tabular data, survival data often come with incomplete event information due…

Machine Learning · Computer Science 2026-02-06 Marie Brockschmidt , Maresa Schröder , Stefan Feuerriegel

Few-shot image synthesis entails generating diverse and realistic images of novel categories using only a few example images. While multiple recent efforts in this direction have achieved impressive results, the existing approaches are…

Computer Vision and Pattern Recognition · Computer Science 2025-06-03 Parul Gupta , Munawar Hayat , Abhinav Dhall , Thanh-Toan Do

Discriminative classifiers have become a foundational tool in deep learning for medical imaging, excelling at learning separable features of complex data distributions. However, these models often need careful design, augmentation, and…

Computer Vision and Pattern Recognition · Computer Science 2025-08-11 Gian Mario Favero , Parham Saremi , Emily Kaczmarek , Brennan Nichyporuk , Tal Arbel