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In this paper, we address the problem of generative dataset distillation that utilizes generative models to synthesize images. The generator may produce any number of images under a preserved evaluation time. In this work, we leverage the…

Computer Vision and Pattern Recognition · Computer Science 2025-04-15 Junqiao Fan , Yunjiao Zhou , Min Chang Jordan Ren , Jianfei Yang

In this paper, we introduce the first diffusion model designed to generate complete synthetic human genotypes, which, by standard protocols, one can straightforwardly expand into full-length, DNA-level genomes. The synthetic genotypes mimic…

Computational Engineering, Finance, and Science · Computer Science 2025-01-31 Philip Kenneweg , Raghuram Dandinasivara , Xiao Luo , Barbara Hammer , Alexander Schönhuth

Motivation: Single cell transcriptome sequencing (scRNA-Seq) has become a revolutionary tool to study cellular and molecular processes at single cell resolution. Among existing technologies, the recently developed droplet-based platform…

Machine Learning · Statistics 2017-04-10 Zhe Sun , Ting Wang , Ke Deng , Xiao-Feng Wang , Robert Lafyatis , Ying Ding , Ming Hu , Wei Chen

Clustering analysis is fundamental in single-cell RNA sequencing (scRNA-seq) data analysis for elucidating cellular heterogeneity and diversity. Recent graph-based scRNA-seq clustering methods, particularly graph neural networks (GNNs),…

Machine Learning · Computer Science 2025-07-15 Ping Xu , Pengfei Wang , Zhiyuan Ning , Meng Xiao , Min Wu , Yuanchun Zhou

Single-cell RNA sequencing (scRNA-seq) has emerged as a transformative technology, offering unparalleled insights into the intricate landscape of cellular diversity and gene expression dynamics. The analysis of scRNA-seq data poses…

Molecular Networks · Quantitative Biology 2023-12-19 Hongsong Feng , Sean Cottrell , Yuta Hozumi , Guo-Wei Wei

This paper introduces the Single-Cell Perturbation Prediction Diffusion Model (scPPDM), the first diffusion-based framework for single-cell drug-response prediction from scRNA-seq data. scPPDM couples two condition channels,…

Quantitative Methods · Quantitative Biology 2025-10-15 Zhaokang Liang , Shuyang Zhuang , Xiaoran Jiao , Weian Mao , Hao Chen , Chunhua Shen

This paper presents our method for the generative track of The First Dataset Distillation Challenge at ECCV 2024. Since the diffusion model has become the mainstay of generative models because of its high-quality generative effects, we…

Computer Vision and Pattern Recognition · Computer Science 2024-08-19 Duo Su , Junjie Hou , Guang Li , Ren Togo , Rui Song , Takahiro Ogawa , Miki Haseyama

Cell clustering is crucial for uncovering cellular heterogeneity in single-cell RNA sequencing (scRNA-seq) data by identifying cell types and marker genes. Despite its importance, benchmarks for scRNA-seq clustering methods remain…

Genomics · Quantitative Biology 2025-12-03 Ping Xu , Zaitian Wang , Zhirui Wang , Pengjiang Li , Jiajia Wang , Ran Zhang , Pengfei Wang , Yuanchun Zhou

The social graphs synthesized by the generative models are increasingly in demand due to data scarcity and concerns over user privacy. One of the key performance criteria for generating social networks is the fidelity to specified…

Social and Information Networks · Computer Science 2023-11-07 Jui-Yi Tsai , Ya-Wen Teng , Ho Chiok Yew , De-Nian Yang , Lydia Y. Chen

Discrete diffusion models are a class of generative models that produce samples from an approximated data distribution within a discrete state space. Often, there is a need to target specific regions of the data distribution. Current…

Machine Learning · Computer Science 2025-09-03 Cheuk Kit Lee , Paul Jeha , Jes Frellsen , Pietro Lio , Michael Samuel Albergo , Francisco Vargas

Single-cell RNA sequencing (scRNA-seq) has the potential to provide powerful, high-resolution signatures to inform disease prognosis and precision medicine. This paper takes an important first step towards this goal by developing an…

Quantitative Methods · Quantitative Biology 2021-10-15 Bryan He , Matthew Thomson , Meena Subramaniam , Richard Perez , Chun Jimmie Ye , James Zou

Dataset distillation reduces the storage and computational consumption of training a network by generating a small surrogate dataset that encapsulates rich information of the original large-scale one. However, previous distillation methods…

Computer Vision and Pattern Recognition · Computer Science 2024-03-26 Jianyang Gu , Saeed Vahidian , Vyacheslav Kungurtsev , Haonan Wang , Wei Jiang , Yang You , Yiran Chen

This work presents RNAdiffusion, a latent diffusion model for generating and optimizing discrete RNA sequences of variable lengths. RNA is a key intermediary between DNA and protein, exhibiting high sequence diversity and complex…

Machine Learning · Computer Science 2024-10-03 Kaixuan Huang , Yukang Yang , Kaidi Fu , Yanyi Chu , Le Cong , Mengdi Wang

The swift advancement of single-cell RNA sequencing (scRNA-seq) technologies enables the investigation of cellular-level tissue heterogeneity. Cell annotation significantly contributes to the extensive downstream analysis of scRNA-seq data.…

Machine Learning · Computer Science 2024-11-28 Huifa Li , Jie Fu , Xinpeng Ling , Zhiyu Sun , Kuncan Wang , Zhili Chen

Diffusion models have demonstrated remarkable performance in generating unimodal data across various tasks, including image, video, and text generation. On the contrary, the joint generation of multimodal data through diffusion models is…

Machine Learning · Computer Science 2025-06-16 Kevin Rojas , Yuchen Zhu , Sichen Zhu , Felix X. -F. Ye , Molei Tao

We propose a probabilistic model for interpreting gene expression levels that are observed through single-cell RNA sequencing. In the model, each cell has a low-dimensional latent representation. Additional latent variables account for…

Machine Learning · Computer Science 2017-10-18 Romain Lopez , Jeffrey Regier , Michael Cole , Michael Jordan , Nir Yosef

Diffusion-based tabular data synthesis models have yielded promising results. However, when the data dimensionality increases, existing models tend to degenerate and may perform even worse than simpler, non-diffusion-based models. This is…

Machine Learning · Computer Science 2025-11-12 Zuqing Li , Junhao Gan , Jianzhong Qi

We introduce OneDiffusion, a versatile, large-scale diffusion model that seamlessly supports bidirectional image synthesis and understanding across diverse tasks. It enables conditional generation from inputs such as text, depth, pose,…

Computer Vision and Pattern Recognition · Computer Science 2025-06-16 Duong H. Le , Tuan Pham , Sangho Lee , Christopher Clark , Aniruddha Kembhavi , Stephan Mandt , Ranjay Krishna , Jiasen Lu

The class-conditional image generation based on diffusion models is renowned for generating high-quality and diverse images. However, most prior efforts focus on generating images for general categories, e.g., 1000 classes in ImageNet-1k. A…

Computer Vision and Pattern Recognition · Computer Science 2024-06-05 Ziying Pan , Kun Wang , Gang Li , Feihong He , Yongxuan Lai

The acquisition of large-scale, high-quality data is a resource-intensive and time-consuming endeavor. Compared to conventional Data Augmentation (DA) techniques (e.g. cropping and rotation), exploiting prevailing diffusion models for data…

Computer Vision and Pattern Recognition · Computer Science 2024-03-20 Yunxiang Fu , Chaoqi Chen , Yu Qiao , Yizhou Yu