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We propose a constrained maximum partial likelihood estimator for dimension reduction in integrative (e.g., pan-cancer) survival analysis with high-dimensional covariates. We assume that for each population in the study, the hazard function…

Methodology · Statistics 2023-04-27 Aaron J. Molstad , Rohit K. Patra

The burden of depression and anxiety in the world is rising. Identification of individuals at increased risk of developing these conditions would help to target them for prevention and ultimately reduce the healthcare burden. We developed a…

Machine Learning · Computer Science 2021-04-21 D. Morelli , N. Dolezalova , S. Ponzo , M. Colombo , D. Plans

Environmental hazards place certain individuals at disproportionately higher risks. As these hazards increasingly endanger human health, precise identification of the most vulnerable population subgroups is critical for public health.…

Machine Learning · Computer Science 2024-09-23 Jong Woo Nam , Eun Young Choi , Jennifer A. Ailshire , Yao-Yi Chiang

Research suggests that exposure to the natural environment can improve mood, however, current reviews are limited in scope and there is little understanding of moderators. We aimed to conduct a comprehensive systematic review and…

Applications · Statistics 2019-10-23 Hannah Roberts , Caspar van Lissa , Paulien Hagedoorn , Ian Kellar , Marco Helbich

Flexible machine learning tools are increasingly used to estimate heterogeneous treatment effects. This paper gives an accessible tutorial demonstrating the use of the causal forest algorithm, available in the R package grf. We start with a…

Applications · Statistics 2024-12-17 Erik Sverdrup , Maria Petukhova , Stefan Wager

The problem of how to best select variables for confounding adjustment forms one of the key challenges in the evaluation of exposure effects in observational studies, and has been the subject of vigorous recent activity in causal inference.…

Methodology · Statistics 2021-12-02 Kelly Van Lancker , Oliver Dukes , Stijn Vansteelandt

This paper presents a novel framework for prioritizing urban green space development in Tehran using diverse socio-economic, environmental, and sensitivity indices. The indices were derived from various sources including Google Earth…

Machine Learning · Computer Science 2025-05-15 Mohammad Ganjirad , Mahmoud Reza Delavar , Hossein Bagheri , Mohammad Mehdi Azizi

From an optimizer's perspective, achieving the global optimum for a general nonconvex problem is often provably NP-hard using the classical worst-case analysis. In the case of Cox's proportional hazards model, by taking its statistical…

Statistics Theory · Mathematics 2021-07-07 Jianqing Fan , Wenyan Gong , Qiang Sun

The shape of the relationship between a continuous exposure variable and a binary disease variable is often central to epidemiologic investigations. This paper investigates a number of issues surrounding inference and the shape of the…

Methodology · Statistics 2019-02-01 Li Xing , Xuekui Zhang , Igor Burstyn , Paul Gustafson

We describe a new approach to estimating relative risks in time-to-event prediction problems with censored data in a fully parametric manner. Our approach does not require making strong assumptions of constant proportional hazard of the…

Machine Learning · Computer Science 2021-06-10 Chirag Nagpal , Xinyu Rachel Li , Artur Dubrawski

We propose a semiparametric model to study the effect of covariates on the distribution of a censored event time while making minimal assumptions about the censoring mechanism. The result is a partially identified model, in the sense that…

Methodology · Statistics 2025-03-19 Ilias Willems , Jad Beyhum , Ingrid Van Keilegom

Remote sensing observations are extensively used for analysis of environmental variables. These variables often exhibit spatial correlation, which has to be accounted for in the calibration models used in predictions, either by direct…

Applications · Statistics 2017-02-14 Virpi Junttila , Marko Laine

Epidemiological evidence supports an association between exposure to air pollution during pregnancy and birth and child health outcomes. Typically, such associations are estimated by regressing an outcome on daily or weekly measures of…

We introduce a pliable lasso method for estimation of interaction effects in the Cox proportional hazards model framework. The pliable lasso is a linear model that includes interactions between covariates X and a set of modifying variables…

Applications · Statistics 2018-07-19 Wenfei Du , Rob Tibshirani

The functional linear model is a popular tool to investigate the relationship between a scalar/functional response variable and a scalar/functional covariate. We generalize this model to a functional linear mixed-effects model when repeated…

Methodology · Statistics 2016-01-07 Baisen Liu , Jiguo Cao

Understanding how environmental drivers relate to vegetation condition motivates spatially varying regression models, but estimating a separate coefficient surface for every predictor can yield noisy patterns and poor interpretability when…

Methodology · Statistics 2026-02-11 Qishi Zhan , Cheng-Han Yu , Yuchi Chen , Zhikang Dong , Rajarshi Guhaniyogi

The health impact of long-term exposure to air pollution is now routinely estimated using spatial ecological studies, due to the recent widespread availability of spatial referenced pollution and disease data. However, this areal unit study…

Applications · Statistics 2014-12-16 Duncan Lee , Christophe Sarran

The function-on-function regression model is fundamental for analyzing relationships between functional covariates and responses. However, most existing function-on-function regression methodologies assume independence between observations,…

Methodology · Statistics 2025-12-02 Ufuk Beyaztas , Han Lin Shang , Gizel Bakicierler Sezer

The instability in the selection of models is a major concern with data sets containing a large number of covariates. This paper deals with variable selection methodology in the case of high-dimensional problems where the response variable…

Applications · Statistics 2012-03-23 Marie Walschaerts , Eve Leconte , Philippe Besse

Spatially misaligned data, where the response and covariates are observed at different spatial locations, commonly arise in many environmental studies. Much of the statistical literature on handling spatially misaligned data has been…

Methodology · Statistics 2023-10-10 Z. Y. Tho , F. K. C. Hui , A. H. Welsh , T. Zou
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