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We present an approach to estimate distance-dependent heterogeneous associations between point-referenced exposures to built environment characteristics and health outcomes. By estimating associations that depend non-linearly on distance…

Methodology · Statistics 2021-07-14 Adam Peterson , Emma Sanchez-Vaznaugh , Brisa Sanchez

The popularity of penalized regression in high-dimensional data analysis has led to a demand for new inferential tools for these models. False discovery rate control is widely used in high-dimensional hypothesis testing, but has only…

Methodology · Statistics 2019-01-24 Ryan Miller , Patrick Breheny

We study the nonparametric covariance estimation of a stationary Gaussian field X observed on a lattice. To tackle this issue, a neighborhood selection procedure has been recently introduced. This procedure amounts to selecting a…

Statistics Theory · Mathematics 2009-09-02 Nicolas Verzelen

The paper explores a different variation of combined regression strategy to calculate the conditional survival function. We use regression based weak learners to create the proposed ensemble technique. The proposed combined regression…

Machine Learning · Computer Science 2023-09-12 Rahul Goswami , Arabin Kr. Dey

Environmental epidemiologic studies routinely utilize aggregate health outcomes to estimate effects of short-term (e.g., daily) exposures that are available at increasingly fine spatial resolutions. However, areal averages are typically…

Applications · Statistics 2023-02-07 Yuzi Zhang , Howard H. Chang , Joshua L. Warren , Stefanie T. Ebelt

For many complex diseases, prognosis is of essential importance. It has been shown that, beyond the main effects of genetic (G) and environmental (E) risk factors, the gene-environment (G$\times$E) interactions also play a critical role. In…

Applications · Statistics 2015-05-15 Hao Chai , Qingzhao Zhang , Yu Jiang , Guohua Wang , Sanguo Zhang , Shuangge Ma

Longitudinal and high-dimensional measurements have become increasingly common in biomedical research. However, methods to predict survival outcomes using covariates that are both longitudinal and high-dimensional are currently missing. In…

Truncation is a statistical phenomenon that occurs in many time to event studies. For example, autopsy-confirmed studies of neurodegenerative diseases are subject to an inherent left and right truncation, also known as double truncation.…

Methodology · Statistics 2018-03-28 Lior Rennert , Sharon X. Xie

Most prediction models that are used in medical research fail to accurately predict health outcomes due to methodological limitations. Using routinely collected patient data, we explore the use of a Cox proportional hazard (PH) model within…

Methodology · Statistics 2019-07-19 John Mbotwa , Marc de Kamps , Paul D. Baxter , Mark S. Gilthorpe

Tree-based priors for probability distributions are usually specified using a predetermined, data-independent collection of candidate recursive partitions of the sample space. To characterize an unknown target density in detail over the…

Methodology · Statistics 2025-04-14 Li Ma , Benedetta Bruni

Cox proportional hazards model is one of the most popular models in biomedical data analysis. There have been continuing efforts to improve the flexibility of such models for complex signal detection, for example, via additive functions.…

Methodology · Statistics 2022-05-25 Boyi Guo , Nengjun Yi

We propose two novel approaches for estimating time-varying effects of functional predictors within a linear functional Cox model framework. This model allows for time-varying associations of a functional predictor observed at baseline,…

Methodology · Statistics 2024-12-20 Hongyu Du , Andrew Leroux

The Cox proportional hazards model is often used to analyze data from Randomized Controlled Trials (RCT) with time-to-event outcomes. Random survival forest (RSF) is a machine-learning algorithm known for its high predictive performance. We…

Machine Learning · Statistics 2025-05-28 Ricarda Graf , Susan Todd , M. Fazil Baksh

Lung cancer remains one of the leading causes of cancer-related mortality, yet most survival models rely only on baseline factors and overlook posttreatment variables that reflect disease progression. To address this gap, we applied Cox…

Applications · Statistics 2025-10-03 Varun Vishwanathan Nair , Victor Miranda Soberanis

Recent research has shown the potential for neural networks to improve upon classical survival models such as the Cox model, which is widely used in clinical practice. Neural networks, however, typically rely on data that are centrally…

Machine Learning · Computer Science 2022-07-12 Dekai Zhang , Francesca Toni , Matthew Williams

A new method for the analysis of time to ankylosis complication on a dataset of replanted teeth is proposed. In this context of left-censored, interval-censored and right-censored data, a Cox model with piecewise constant baseline hazard is…

Methodology · Statistics 2020-10-15 Olivier Bouaziz , Eva Lauridsen , Grégory Nuel

Assessing associations between a response of interest and a set of covariates in spatial areal models is the leitmotiv of ecological regression. However, the presence of spatially correlated random effects can mask or even bias estimates of…

Methodology · Statistics 2021-06-02 A. Adin , T. Goicoa , J. S. Hodges , P. Schnell , M. D. Ugarte

In this work, we propose a new Bayesian spatial homogeneity pursuit method for survival data under the proportional hazards model to detect spatially clustered patterns in baseline hazard and regression coefficients. Specially, regression…

Applications · Statistics 2021-02-24 Lijiang Geng , Guanyu Hu

The current analysis of wireless networks whose transceivers are confined to streets is largely based on Poissonian models, such as Poisson line processes and Poisson line Cox processes. We demonstrate important scenarios where a model with…

Information Theory · Computer Science 2023-06-14 Mohammad Taha Shah , Gourab Ghatak , Souradip Sanyal , Martin Haenggi

We propose the spatial-temporal aggregated predictor (STAP) modeling framework to address measurement and estimation issues that arise when assessing the relationship between built environment features (BEF) and health outcomes. Many BEFs…

Methodology · Statistics 2021-05-25 Adam Peterson , Jana Hirsch , Brisa Sanchez