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Multi-omic datasets offer opportunities for improved biomarker discovery in cancer research, but their high dimensionality and limited sample sizes make identifying compact and effective biomarker panels challenging. Feature selection in…

Genomics · Quantitative Biology 2026-04-02 Luca Cattelani , Vittorio Fortino

Microarray gene expression data are often accompanied by a large number of genes and a small number of samples. However, only a few of these genes are relevant to cancer, resulting in signigicant gene selection challenges. Hence, we propose…

Machine Learning · Computer Science 2021-06-11 Xiongshi Deng , Min Li , Shaobo Deng , Lei Wang

Advances in data collecting technologies in genomics have significantly increased the need for tools designed to study the genetic basis of many diseases. Effective statistical methods should excel in both prediction accuracy and biomarker…

Methodology · Statistics 2025-11-13 Anthony-Alexander Christidis , Stefan Van Aelst , Ruben Zamar

The problem of chemotherapy treatment optimization can be defined in order to minimize the size of the tumor without endangering the patient's health; therefore, chemotherapy requires to achieve a number of objectives, simultaneously. For…

Neural and Evolutionary Computing · Computer Science 2023-03-21 Mina Jafari , Behnam Ghavami , Vahid Sattari Naeini

In the hardware design space exploration process, it is critical to optimize both hardware parameters and algorithm-to-hardware mappings. Previous work has largely approached this simultaneous optimization problem by separately exploring…

Hardware Architecture · Computer Science 2025-09-16 Charles Hong , Qijing Huang , Grace Dinh , Mahesh Subedar , Yakun Sophia Shao

Biomedical data is filled with continuous real values; these values in the feature set tend to create problems like underfitting, the curse of dimensionality and increase in misclassification rate because of higher variance. In response,…

Artificial Intelligence · Computer Science 2020-04-17 Deepak Singh , Dilip Singh Sisodia , Pradeep Singh

The main feature of the Dynamic Multi-objective Optimization Problems (DMOPs) is that optimization objective functions will change with times or environments. One of the promising approaches for solving the DMOPs is reusing the obtained…

Neural and Evolutionary Computing · Computer Science 2019-10-22 Weizhen Hu , Min Jiang , Xing Gao , Kay Chen Tan , Yiu-ming Cheung

In recommender systems, it is well-established that both accuracy and diversity are crucial for generating high-quality recommendation lists. However, achieving a balance between these two typically conflicting objectives remains a…

Information Retrieval · Computer Science 2026-04-10 Elaheh Lotfian , Alireza Kabgani

Objective: Accurately classifying the malignancy of lesions detected in a screening scan is critical for reducing false positives. Radiomics holds great potential to differentiate malignant from benign tumors by extracting and analyzing a…

Computer Vision and Pattern Recognition · Computer Science 2019-02-14 Zhiguo Zhou , Shulong Li , Genggeng Qin , Michael Folkert , Steve Jiang , Jing Wang

Massive multiple input multiple output(MIMO)-based fully-digital receive antenna arrays bring huge amount of complexity to both traditional direction of arrival(DOA) estimation algorithms and neural network training, which is difficult to…

Signal Processing · Electrical Eng. & Systems 2023-01-18 Yiwen Chen , Xichao Zhan , Feng Shu

The application of machine learning methods to analyze changes in gene expression patterns has recently emerged as a powerful approach in cancer research, enhancing our understanding of the molecular mechanisms underpinning cancer…

Machine Learning · Computer Science 2024-09-02 Fadi Alharbi , Aleksandar Vakanski , Murtada K. Elbashir , Mohanad Mohammed

In expensive multi-objective optimization, where the evaluation budget is strictly limited, selecting promising candidate solutions for expensive fitness evaluations is critical for accelerating convergence and improving algorithmic…

Neural and Evolutionary Computing · Computer Science 2025-06-16 Huixiang Zhen , Xiaotong Li , Wenyin Gong , Xiangyun Hu

Studies have shown that multi-objective optimization problems are hard problems. Such problems either require longer time to converge to an optimum solution, or may not converge at all. Recently some researchers have claimed that real…

Neural and Evolutionary Computing · Computer Science 2014-06-11 Shahab U. Ansari , Sameen Mansha

The Horse Herd Optimization Algorithm (HOA) is a new meta-heuristic algorithm based on the behaviors of horses at different ages. The HOA was introduced recently to solve complex and high-dimensional problems. This paper proposes a binary…

Machine Learning · Computer Science 2023-11-30 Niloufar Mehrabi , Sayed Pedram Haeri Boroujeni , Elnaz Pashaei

Selecting the most relevant or informative features is a key issue in actual machine learning problems. Since an exhaustive search is not feasible even for a moderate number of features, an intelligent search strategy must be employed for…

Neural and Evolutionary Computing · Computer Science 2026-04-08 Leandro Vignolo , Matias Gerard

Variable selection is recognized as one of the most critical steps in statistical modeling. The problems encountered in engineering and social sciences are commonly characterized by over-abundance of explanatory variables, non-linearities…

Computation · Statistics 2016-07-14 Ankur Sinha , Pekka Malo , Timo Kuosmanen

Motivation: Gene selection has become a common task in most gene expression studies. The objective of such research is often to identify the smallest possible set of genes that can still achieve good predictive performance. The problem of…

In this work, we study and analyze different feature selection algorithms that can be used to classify cancer subtypes in case of highly varying high-dimensional data. We apply three different feature selection methods on five different…

Machine Learning · Computer Science 2021-10-01 Vaibhav Sinha , Siladitya Dash , Nazma Naskar , Sk Md Mosaddek Hossain

The Multi-Objective Real-Valued Gene-pool Optimal Mixing Evolutionary Algorithm (MO-RV-GOMEA) has been proven effective and efficient in solving real-world problems. A prime example is optimizing treatment plans for prostate cancer…

Neural and Evolutionary Computing · Computer Science 2022-03-18 Leah R. M. Dickhoff , Ellen M. Kerkhof , Heloisa H. Deuzeman , Carien L. Creutzberg , Tanja Alderliesten , Peter A. N. Bosman

In recent years the importance of finding a meaningful pattern from huge datasets has become more challenging. Data miners try to adopt innovative methods to face this problem by applying feature selection methods. In this paper we propose…

Machine Learning · Computer Science 2014-03-11 Mehdi Naseriparsa , Amir-masoud Bidgoli , Touraj Varaee
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