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We study a model of contraction-based cell motility inside a microchannel to investigate the regulation of cell polarization and motion by the mechanical resistance of the environment. A positive feedback between the asymmetry of the…

Biological Physics · Physics 2024-02-28 Tapas Singha , Pierre Sens

Upcoming immunotherapies for cancer treatment rely on the ability of the immune system to detect and eliminate tumors in the body. A highly simplified version of this process can be studied in a Petri dish: starting with a random…

Quantitative Methods · Quantitative Biology 2019-07-25 Claus Metzner

Cell membranes are studded with protrusions that were thoroughly analyzed with electron microscopy. However, the nanometer-scale three-dimensional motions generated by cell membranes to fit the topography of foreign surfaces and initiate…

Biological Physics · Physics 2008-09-04 Anne Pierres , Anne-Marie Benoliel , Dominique Touchard , Pierre Bongrand

A rigorous homogenization theory is derived to describe the effective admittivity of cell suspensions. A new formula is reported for dilute cases that gives the frequency-dependent effective admittivity with respect to the membrane…

Analysis of PDEs · Mathematics 2013-10-07 Habib Ammari , Josselin Garnier , Laure Giovangigli , Wenjia Jing , Jin-Keun Seo

Optimal characterization of the mechanical properties of both cells and their surrounding is an issue of major interest. Indeed, cell function and development are strongly influenced by external stimuli. Furthermore, a change in cell…

The molecular photo cell, i.e., a single molecule donor-acceptor complex, beside being technologically important, is a paradigmatic example of a many-body system operating in strong non-equilibrium. The quantum transport and the…

Mesoscale and Nanoscale Physics · Physics 2020-07-06 Subhajit Sarkar , Yonatan Dubi

The excitation of many cells and tissues is associated with cell mechanical changes. The evidence presented herein corroborates that single cells deform during an action potential (AP). It is demonstrated that excitation of plant cells…

Biological Physics · Physics 2018-07-17 Christian Fillafer , Matan Mussel , Julia Muchowski , Matthias F. Schneider

The mechanical deformability of single cells is an important indicator for various diseases such as cancer, blood diseases and inflammation. Lab-on-a-chip devices allow to separate such cells from healthy cells using hydrodynamic forces. We…

Fluid Dynamics · Physics 2019-02-08 Christian Schaaf , Holger Stark

The dynamics of receding contact lines is investigated experimentally through controlled perturbations of a meniscus in a dip coating experiment. We first characterize stationary menisci and their breakdown at the coating transition. It is…

Fluid Dynamics · Physics 2015-05-13 G. Delon , M. Fermigier , J. H. Snoeijer , B. Andreotti

The problem of the detachment of a sufficiently large flat indenter from a plane adhesive viscoelastic strip of thickness "b" is studied. For any given retraction speed, three different detachment regimes are found: (i) for very small "b"…

Soft Condensed Matter · Physics 2024-04-05 Ali Maghami , Michele Ciavarella , Antonio Papangelo

We investigate clustering of malignant glioma cells. \emph{In vitro} experiments in collagen gels identified a cell line that formed clusters in a region of low cell density, whereas a very similar cell line (which lacks an important…

Cellulose, as a naturally abundant and biocompatible material, is still gaining interest due to its high potential for functionalization. This makes cellulose a promising candidate for replacing plastics. Understanding how cellulose…

A recently suggested reciprocity relation states that the current transport efficiency from the junction to the cell terminal can be determined by differentiating luminescence images with respect to the terminal voltage. The validity of…

A general problem arising in computer simulations is the number of material and device parameters, which have to be determined by dedicated experiments and simulation-based parameter extraction. In this study we analyze measurements of the…

Materials Science · Physics 2009-11-19 R. Hausermann , E. Knapp , M. Moos , N. A. Reinke , T. Flatz , B. Ruhstaller

Test of independence is of fundamental importance in modern data analysis, with broad applications in variable selection, graphical models, and causal inference. When the data is high dimensional and the potential dependence signal is…

Methodology · Statistics 2023-06-13 Zhanrui Cai , Jing Lei , Kathryn Roeder

Results on the rheological behavior of novel CHO cell suspensions in a large range of concentrations are reported. The concentration dependent yield stress and elastic plateau modulus are formalized in the context of fractal aggregates…

Soft Condensed Matter · Physics 2009-11-13 Andreea Iordan , Alain Duperray , Claude Verdier

The shape that stem cells reach at the end of adhesion process influences their differentiation. Rearrangement of cytoskeleton and modification of intracellular tension may activate mechanotransduction pathways controlling cell commitment.…

The work is devoted to the analysis of cell population dynamics where cells make a choice between differentiation and apoptosis. This choice is based on the values of intracellular proteins whose concentrations are described by a system of…

Cell Behavior · Quantitative Biology 2016-03-30 Malay Banerjee , Vitaly Volpert

Cellular form and function emerge from complex mechanochemical systems within the cytoplasm. No systematic strategy currently exists to infer large-scale physical properties of a cell from its many molecular components. This is a…

In the course of animal development, the shape of tissue emerges in part from mechanical and biochemical interactions between cells. Measuring stress in tissue is essential for studying morphogenesis and its physical constraints.…

Quantitative Methods · Quantitative Biology 2013-01-21 S. Ishihara , K. Sugimura , S. J. Cox , I. Bonnet , Y. Bellaiche , F. Graner
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