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We rigorously investigate the convergence of a new numerical method, recently proposed by the authors, to approximate the reproduction numbers of a large class of age-structured population models with finite age span. The method consists in…

Numerical Analysis · Mathematics 2024-09-04 Simone De Reggi , Francesca Scarabel , Rossana Vermiglio

As widely known, the basic reproduction number plays a key role in weighing birth/infection and death/recovery processes in several models of population dynamics. In this general setting, its characterization as the spectral radius of next…

Numerical Analysis · Mathematics 2020-04-29 Dimitri Breda , Francesco Florian , Jordi Ripoll , Rossana Vermiglio

We propose a novel approach to approximate the basic reproduction number $R_0$ as spectral radius of the Next-Generation Operator in time-periodic population models by characterizing the latter via evolution semigroups. Once birth/infection…

Numerical Analysis · Mathematics 2025-09-03 Dimitri Breda , Simone De Reggi , Jordi Ripoll

This chapter reviews some aspects of the theory of age-structured models of populations with finite maximum age. We formulate both the renewal equation for the birth rate and the partial differential equation for the age density, and show…

Populations and Evolution · Quantitative Biology 2025-10-21 Odo Diekmann , Francesca Scarabel

Reproduction numbers are widely used for the estimation and prediction of epidemic spreading processes over networks. However, reproduction numbers do not enable estimation and prediction in individual communities within networks, and they…

Systems and Control · Electrical Eng. & Systems 2025-06-23 Baike She , Philip E. Paré , Matthew Hale

Reproduction numbers, like the basic reproduction number $\mathcal{R}_0$, play an important role in the analysis and application of dynamic models, including contagion models and ecological population models. One difficulty in deriving…

Populations and Evolution · Quantitative Biology 2021-05-25 Paul J. Hurtado , Cameron Richards

In the framework of population dynamics, the basic reproduction number R_0 is, by definition, the expected number of offspring that an individual has during its lifetime. In constant and time periodic environments it is calculated as the…

Analysis of PDEs · Mathematics 2026-04-16 Carles Barril , Àngel Calsina , Sílvia Cuadrado , Jordi Ripoll

The effective reproduction number, R(t), is a central point in the study of infectious diseases. It establishes in an explicit way the extent of an epidemic spread process in a population. The current estimation methods for the time…

Populations and Evolution · Quantitative Biology 2021-02-26 D. C. P. Jorge , J. F. Oliveira , J. G. V. Miranda , R. F. S. Andrade , S. T. R. Pinho

When an infectious disease strikes a population, the number of newly reported cases is often the only available information that one can obtain during early stages of the outbreak. An important goal of early outbreak analysis is to obtain a…

Quantitative Methods · Quantitative Biology 2013-05-30 Bahman Davoudi , Babak Pourbohloul , Joel Miller , Rafael Meza , Lauren Ancel Meyers , David J. D. Earn

In this paper, we provide a straightforward approach to defining and deriving the key epidemiological quantity, the basic reproduction number, $R_0$, for Markovian epidemics in structured populations. The methodology derived is applicable…

Populations and Evolution · Quantitative Biology 2019-03-26 Peter Neal , Thitiya Theparod

We propose a numerical method for approximating integro-differential equations arising in age-of-infection epidemic models. The method is based on a non-standard finite differences approximation of the integral term appearing in the…

Numerical Analysis · Mathematics 2024-07-22 Eleonora Messina , Mario Pezzella , Antonia Vecchio

The effect of diffusion rates on the basic reproduction number of a general compartmental reaction-diffusion epidemic model in a heterogeneous environment is considered. It is shown when the diffusion rates tend to zero, the limit of the…

Dynamical Systems · Mathematics 2019-09-24 Shanshan Chen , Junping Shi

This paper considers a nonlinear model for population dynamics with age structure. The fertility rate with respect to age is non constant and has the form proposed by [17]. Moreover, its multiplicative structure and the multiplicative…

General Mathematics · Mathematics 2023-12-06 Dragos-Patru Covei , Traian A. Pirvu , Catalin Sterbeti

In the present paper, our goal is to establish a framework for the mathematical modelling and the analysis of the spread of an epidemic in a large population commuting regularly, typically along a time-periodic pattern, as is roughly…

Populations and Evolution · Quantitative Biology 2024-08-29 Pierre-Alexandre Bliman , Boureima Sangaré , Assane Savadogo

Early estimates of the transmission potential of emerging and re-emerging infections are increasingly used to inform public health authorities on the level of risk posed by outbreaks. Existing methods to estimate the reproduction number…

Quantitative Methods · Quantitative Biology 2016-10-10 Gerardo Chowell , Cécile Viboud , Lone Simonsen , Seyed Moghadas

In this paper, we introduce and study an age-structured epidemiological compartment model and its respective problem, applied but not limited to the COVID-19 pandemic, in order to investigate the role of the age of the individuals in the…

Dynamical Systems · Mathematics 2023-11-28 Vasiliki Bitsouni , Nikolaos Gialelis , Vasilis Tsilidis

This is a pedagogical paper on estimating the number of people that can be infected by one infectious person during an epidemic outbreak, known as the reproduction number. Knowing the number is crucial for developing policy responses. There…

Populations and Evolution · Quantitative Biology 2020-06-30 H. Susanto , V. R. Tjahjono , A. Hasan , M. F. Kasim , N. Nuraini , E. R. M. Putri , R. Kusdiantara , H. Kurniawan

The goal of this note is to present a general approach to define the net reproduction function for a large class of nonlinear physiologically structured population models. In particular, we are going to show that this can be achieved in a…

Populations and Evolution · Quantitative Biology 2019-03-06 József Z. Farkas

Macro-level modeling is still the dominant approach in many demographic applications because of its simplicity. Individual-level models, on the other hand, provide a more comprehensive understanding of observed patterns; however, their…

Applications · Statistics 2023-12-14 Daniel Ciganda , Nicolas Todd

Birth-death processes track the size of a univariate population, but many biological systems involve interaction between populations, necessitating models for two or more populations simultaneously. A lack of efficient methods for…

Computation · Statistics 2017-08-08 Lam Si Tung Ho , Jason Xu , Forrest W. Crawford , Vladimir N. Minin , Marc A. Suchard
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