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Electronic health records (EHRs) are designed to synthesize diverse data types, including unstructured clinical notes, structured lab tests, and time-series visit data. Physicians draw on these multimodal and temporal sources of EHR data to…

Rare diseases affect 1 in 10 Americans yet remain systematically underdocumented in clinical records. ICD-based systems cannot capture their breadth, over 50\% of Orphanet codes lack a direct ICD mapping and only 2.2\% of HPO codes have…

Machine Learning · Computer Science 2026-05-14 John Wu , Adam Cross , Jimeng Sun

Pharmacovigilance and clinical decision support systems utilize structured drug safety data to guide medical practice. However, existing datasets frequently depend on terminologies such as MedDRA, which limits their semantic reasoning…

Information Retrieval · Computer Science 2026-02-24 Mohammad Ashhad , Olga Mashkova , Ricardo Henao , Robert Hoehndorf

Evidence suggests that medication adherence applications (apps) are one of the most effective methods to remind patients to take medication on time. Reminders via apps are overwhelming today, consumers discard using them after a brief…

Human-Computer Interaction · Computer Science 2023-10-24 Nawal Chanane , Farhaan Mirza , M. Asif Naeem

Accurate ground truth estimation in medical screening programs often relies on coalitions of experts and peer second opinions. Algorithms that efficiently aggregate noisy annotations can enhance screening workflows, particularly when data…

Machine Learning · Computer Science 2025-10-07 Tim Bary , Tiffanie Godelaine , Axel Abels , Benoît Macq

Extracting sections from clinical notes is crucial for downstream analysis but is challenging due to variability in formatting and labor-intensive nature of manual sectioning. While proprietary large language models (LLMs) have shown…

Computation and Language · Computer Science 2025-01-27 Joshua Davis , Thomas Sounack , Kate Sciacca , Jessie M Brain , Brigitte N Durieux , Nicole D Agaronnik , Charlotta Lindvall

Improving effectiveness and safety of patient care is an ultimate objective for medical cyber-physical systems. A recent study shows that the patients' death rate can be reduced by computerizing medical guidelines. Most existing medical…

Software Engineering · Computer Science 2018-11-21 Chunhui Guo , Zhicheng Fu , Zhenyu Zhang , Shangping Ren , Lui Sha

Unstructured clinical notes contain essential patient information but are challenging for physicians to search and interpret efficiently. Although large language models (LLMs) have shown promise in question answering (QA), most existing…

Human-Computer Interaction · Computer Science 2025-05-27 Dina Albassam

When training clinical prediction models from electronic health records (EHRs), a key concern should be a model's ability to sustain performance over time when deployed, even as care practices, database systems, and population demographics…

This survey explores the transformative impact of foundation models (FMs) in artificial intelligence, focusing on their integration with federated learning (FL) for advancing biomedical research. Foundation models such as ChatGPT, LLaMa,…

Machine Learning · Computer Science 2024-05-14 Xingyu Li , Lu Peng , Yuping Wang , Weihua Zhang

Many practical applications of AI in medicine consist of semi-supervised discovery: The investigator aims to identify features of interest at a resolution more fine-grained than that of the available human labels. This is often the scenario…

Computation and Language · Computer Science 2020-04-08 Allen Schmaltz , Andrew Beam

Medical task-oriented dialogue systems can assist doctors by collecting patient medical history, aiding in diagnosis, or guiding treatment selection, thereby reducing doctor burnout and expanding access to medical services. However,…

Computation and Language · Computer Science 2024-10-21 Vishal Vivek Saley , Goonjan Saha , Rocktim Jyoti Das , Dinesh Raghu , Mausam

Sepsis is an important cause of mortality, especially in intensive care unit (ICU) patients. Developing novel methods to identify early mortality is critical for improving survival outcomes in sepsis patients. Using the MIMIC-III database,…

Computers and Society · Computer Science 2021-12-03 Jiyoung Shin , Yikuan Li , Yuan Luo

As the performance of large language models (LLMs) continues to advance, their adoption in the medical domain is increasing. However, most existing risk evaluations largely focused on general safety benchmarks. In the medical applications,…

Computation and Language · Computer Science 2026-01-12 Jean-Philippe Corbeil , Minseon Kim , Maxime Griot , Sheela Agarwal , Alessandro Sordoni , Francois Beaulieu , Paul Vozila

The clinical notes are usually typed into the system by physicians. They are typically required to be marked by standard medical codes, and each code represents a diagnosis or medical treatment procedure. Annotating these notes is time…

Machine Learning · Computer Science 2023-05-10 Guodong Liu

The Large Scale Visual Recognition Challenge based on the well-known Imagenet dataset catalyzed an intense flurry of progress in computer vision. Benchmark tasks have propelled other sub-fields of machine learning forward at an equally…

Machine Learning · Computer Science 2020-10-06 David Bellamy , Leo Celi , Andrew L. Beam

Healthcare is one of the largest business segments in the world and is a critical area for future growth. In order to ensure efficient access to medical and patient-related information, hospitals have invested heavily in improving clinical…

Computers and Society · Computer Science 2018-07-06 Andrea Marrella , Massimo Mecella , Mahmoud Sharf , Tiziana Catarci

Pharmaceutical industry can better leverage its data assets to virtualize drug discovery through a collaborative machine learning platform. On the other hand, there are non-negligible risks stemming from the unintended leakage of…

Cryptography and Security · Computer Science 2022-06-10 Balazs Pejo , Mina Remeli , Adam Arany , Mathieu Galtier , Gergely Acs

Dynamic treatment regimes (DTRs) are critical to precision medicine, optimizing long-term outcomes through personalized, real-time decision-making in evolving clinical contexts, but require careful supervision for unsafe treatment risks.…

Machine Learning · Computer Science 2025-06-10 Yishan Shen , Yuyang Ye , Hui Xiong , Yong Chen

Clinical decision-making requires synthesizing heterogeneous evidence, including patient histories, clinical guidelines, and trajectories of comparable cases. While large language models (LLMs) offer strong reasoning capabilities, they…

Artificial Intelligence · Computer Science 2026-03-03 Shuheng Chen , Namratha Patil , Haonan Pan , Angel Hsing-Chi Hwang , Yao Du , Ruishan Liu , Jieyu Zhao