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Melanoma is the most lethal form of skin cancer, with an increasing incidence rate worldwide. Analyzing histological images of melanoma by localizing and classifying tissues and cell nuclei is considered the gold standard method for…

Computer Vision and Pattern Recognition · Computer Science 2025-09-03 Nima Torbati , Anastasia Meshcheryakova , Ramona Woitek , Sepideh Hatamikia , Diana Mechtcheriakova , Amirreza Mahbod

We share our recent findings in an attempt to train a universal segmentation network for various cell types and imaging modalities. Our method was built on the generalized U-Net architecture, which allows the evaluation of each component…

Computer Vision and Pattern Recognition · Computer Science 2022-08-01 Tianqi Guo , Yin Wang , Luis Solorio , Jan P. Allebach

Developing an AI-assisted gland segmentation method from histology images is critical for automatic cancer diagnosis and prognosis; however, the high cost of pixel-level annotations hinders its applications to broader diseases. Existing…

Computer Vision and Pattern Recognition · Computer Science 2022-06-28 Yi Li , Yiduo Yu , Yiwen Zou , Tianqi Xiang , Xiaomeng Li

Accurate lung tumor segmentation is crucial for improving diagnosis, treatment planning, and patient outcomes in oncology. However, the complexity of tumor morphology, size, and location poses significant challenges for automated…

Image and Video Processing · Electrical Eng. & Systems 2026-02-16 Elena Mulero Ayllón , Massimiliano Mantegna , Linlin Shen , Paolo Soda , Valerio Guarrasi , Matteo Tortora

We propose a method to accurately obtain the ratio of tumor cells over an entire histological slide. We use deep fully convolutional neural network models trained to detect and classify cells on images of H&E-stained tissue sections.…

Image and Video Processing · Electrical Eng. & Systems 2021-01-29 Eric Cosatto , Kyle Gerard , Hans-Peter Graf , Maki Ogura , Tomoharu Kiyuna , Kanako C. Hatanaka , Yoshihiro Matsuno , Yutaka Hatanaka

Background and objective: Cell-level pathological image analysis requires working with extremely small image patches (40x40 pixels), far below standard ImageNet resolutions. It remains unclear whether modern deep learning architectures and…

Computer Vision and Pattern Recognition · Computer Science 2026-03-05 Hiroki Kagiyama , Toru Nagasaka , Yukari Adachi , Takaaki Tachibana , Ryota Ito , Mitsugu Fujita , Kimihiro Yamashita , Yoshihiro Kakeji

Medical image foundation models have shown the ability to segment organs and tumors with minimal fine-tuning. These models are typically evaluated on task-specific in-distribution (ID) datasets. However, reliable performance on ID datasets…

Image and Video Processing · Electrical Eng. & Systems 2025-01-31 Aneesh Rangnekar , Nishant Nadkarni , Jue Jiang , Harini Veeraraghavan

Recent trends in cell segmentation have shifted towards universal models to handle diverse cell morphologies and imaging modalities. However, for continuously emerging cell types and imaging techniques, these models still require hundreds…

Computer Vision and Pattern Recognition · Computer Science 2024-12-03 Peilin Zhou , Bo Du , Yongchao Xu

Optical coherence tomography (OCT) is a medical imaging modality that allows us to probe deeper substructures of skin. The state-of-the-art wound care prediction and monitoring methods are based on visual evaluation and focus on surface…

Image and Video Processing · Electrical Eng. & Systems 2023-06-05 Prashant Kumar , Swatantra Dhara , Ayan Gope , Jyotirmoy Chatterjee , Subhamoy Mandal

Identifying cell types and subtypes in routine histopathology is fundamental for understanding disease. Existing tile-based models capture nuclear detail but miss the broader tissue context that influences cell identity. Current human…

Computer Vision and Pattern Recognition · Computer Science 2025-11-20 Yinuo Xu , Yan Cui , Mingyao Li , Zhi Huang

Cell instance segmentation in fluorescence microscopy images is becoming essential for cancer dynamics and prognosis. Data extracted from cancer dynamics allows to understand and accurately model different metabolic processes such as…

We use partial class memberships in soft classification to model uncertain labelling and mixtures of classes. Partial class memberships are not restricted to predictions, but may also occur in reference labels (ground truth, gold standard…

Machine Learning · Statistics 2013-08-23 Claudia Beleites , Reiner Salzer , Valter Sergo

Live cell culture is crucial in biomedical studies for analyzing cell properties and dynamics in vitro. This study focuses on segmenting unstained live cells imaged with bright-field microscopy. While many segmentation approaches exist for…

Quantitative Methods · Quantitative Biology 2025-08-26 Surajit Das , Gourav Roy , Pavel Zun

Existing state-of-the-art 3D instance segmentation methods perform semantic segmentation followed by grouping. The hard predictions are made when performing semantic segmentation such that each point is associated with a single class.…

Computer Vision and Pattern Recognition · Computer Science 2022-03-04 Thang Vu , Kookhoi Kim , Tung M. Luu , Xuan Thanh Nguyen , Chang D. Yoo

Cell instance segmentation is critical to analyzing biomedical images, yet accurately distinguishing tightly touching cells remains a persistent challenge. Existing instance segmentation frameworks, including detection-based, contour-based,…

Computer Vision and Pattern Recognition · Computer Science 2025-06-12 Ye Zhang , Yu Zhou , Yifeng Wang , Jun Xiao , Ziyue Wang , Yongbing Zhang , Jianxu Chen

Skin-like tactile sensors provide robots with rich feedback related to the force distribution applied to their soft surface. The complexity of interpreting raw tactile information has driven the use of machine learning algorithms to convert…

Robotics · Computer Science 2019-12-12 Carmelo Sferrazza , Adam Wahlsten , Camill Trueeb , Raffaello D'Andrea

Pathology Foundation Models (FMs) have shown strong performance across a wide range of pathology image representation and diagnostic tasks. However, FMs do not exhibit the expected performance advantage over traditional specialized models…

Computer Vision and Pattern Recognition · Computer Science 2026-03-05 Zijiang Yang , Chen Kuang , Dongmei Fu

We propose a new multiclass weighted loss function for instance segmentation of cluttered cells. We are primarily motivated by the need of developmental biologists to quantify and model the behavior of blood T-cells which might help us in…

Computer Vision and Pattern Recognition · Computer Science 2018-10-24 Fidel A. Guerrero-Pena , Pedro D. Marrero Fernandez , Tsang Ing Ren , Mary Yui , Ellen Rothenberg , Alexandre Cunha

Accurately segmenting and individualizing cells in SEM images is a highly promising technique for elucidating tissue architecture in oncology. While current AI-based methods are effective, errors persist, necessitating time-consuming manual…

Image and Video Processing · Electrical Eng. & Systems 2025-04-11 Florian Robert , Alexia Calovoulos , Laurent Facq , Fanny Decoeur , Etienne Gontier , Christophe F. Grosset , Baudouin Denis de Senneville

Pretraining on large-scale, in-domain datasets grants histopathology foundation models (FM) the ability to learn task-agnostic data representations, enhancing transfer learning on downstream tasks. In computational pathology, automated…

Computer Vision and Pattern Recognition · Computer Science 2025-07-22 Pablo Meseguer , Rocío del Amor , Valery Naranjo