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In this paper we introduce a new mathematical model for the active contraction of cardiac muscle, featuring different thermo-electric and nonlinear conductivity properties. The passive hyperelastic response of the tissue is described by an…

Tissues and Organs · Quantitative Biology 2019-05-02 Ricardo Ruiz Baier , Alessio Gizzi , Alessandro Loppini , Christian Cherubini , Simonetta Filippi

Most existing learning-based methods for solving imaging inverse problems can be roughly divided into two classes: iterative algorithms, such as plug-and-play and diffusion methods leveraging pretrained denoisers, and unrolled architectures…

Image and Video Processing · Electrical Eng. & Systems 2026-03-31 Matthieu Terris , Samuel Hurault , Maxime Song , Julian Tachella

In this paper we deal with the problem of determining perfectly insulating regions (cavities) from boundary measurements in a nonlinear elliptic equation arising from cardiac electrophysiology. With minimal regularity assumptions on the…

Analysis of PDEs · Mathematics 2022-09-14 E. Beretta , M. C. Cerutti , D. Pierotti

The inverse conductivity problem aims at determining the unknown conductivity inside a bounded domain from boundary measurements. In practical applications, algorithms based on minimizing a regularized residual functional subject to PDE…

Numerical Analysis · Mathematics 2025-10-02 Lefu Cai , Zhixin Liu , Minghui Song , Xianchao Wang

We consider the common problem setting of an elastic sphere impacting on a flexible beam. In contrast to previous studies, we analyze the modal energy distribution induced by the impact, having in mind the particular application of impact…

Systems and Control · Electrical Eng. & Systems 2022-07-05 Felix Gehr , Timo Theurich , Carlo Monjaraz-Tec , Johann Gross , Stefan Schwarz , Andreas Hartung , Malte Krack

In this paper, we address the challenging problem of optimal experimental design (OED) of constrained inverse problems. We consider two OED formulations that allow reducing the experimental costs by minimizing the number of measurements.…

Numerical Analysis · Mathematics 2017-08-17 Lars Ruthotto , Julianne Chung , Matthias Chung

Mathematical modeling of cardiac function can provide augmented simulation-based diagnosis tool for complementing and extending human understanding of cardiac diseases which represent the most common cause of worldwide death. As the…

Computational Engineering, Finance, and Science · Computer Science 2021-05-05 Chi Zhang , Jianhang Wang , Massoud Rezavand , Dong Wu , Xiangyu Hu

This work presents a matrix-free finite element solver for finite-strain elasticity adopting an $hp$-multigrid preconditioner. Compared to classical algorithms relying on a global sparse matrix, matrix-free solution strategies significantly…

Computational Engineering, Finance, and Science · Computer Science 2024-12-09 Richard Schussnig , Niklas Fehn , Peter Munch , Martin Kronbichler

We introduce a new geometric approach for the homogenization and inverse homogenization of the divergence form elliptic operator with rough conductivity coefficients $\sigma(x)$ in dimension two. We show that conductivity coefficients are…

Analysis of PDEs · Mathematics 2009-05-13 Mathieu Desbrun , Roger D. Donaldson , Houman Owhadi

This work considers Bayesian experimental design for the inverse boundary value problem of linear elasticity in a two-dimensional setting. The aim is to optimize the positions of compactly supported pressure activations on the boundary of…

Numerical Analysis · Mathematics 2023-09-06 Sarah Eberle-Blick , Nuutti Hyvönen

Inverse problems for Partial Differential Equations (PDEs) are crucial in numerous applications such as geophysics, biomedical imaging, and material science, where unknown physical properties must be inferred from indirect measurements. In…

Numerical Analysis · Mathematics 2025-11-12 Dabin Park , Sanghyun Lee , Sunghwan Moon

We present a loosely coupled scheme for the numerical simulation of the cardiac electro-fluid-structure interaction problem, whose solution is typically computationally intensive due to the need to suitably treat the coupling of the…

Numerical Analysis · Mathematics 2023-08-09 Michele Bucelli , Martin Geraint Gabriel , Giacomo Gigante , Alfio Quarteroni , Christian Vergara

Cardiac myocytes are the fundamental cells composing the heart muscle. The propagation of electric signals and chemical quantities through them is responsible for their nonlinear contraction and dilatation. In this study, a theoretical…

Soft Condensed Matter · Physics 2018-08-01 Pietro Lenarda , Alessio Gizzi , Marco Paggi

Existing physical model-based imaging methods for ultrasound elasticity reconstruction utilize fixed variational regularizers that may not be appropriate for the application of interest or may not capture complex spatial prior information…

Image and Video Processing · Electrical Eng. & Systems 2021-03-29 Narges Mohammadi , Marvin M. Doyley , Mujdat Cetin

Solving inverse problems in cardiovascular modeling is particularly challenging due to the high computational cost of running high-fidelity simulations. In this work, we focus on Bayesian parameter estimation and explore different methods…

Machine Learning · Statistics 2025-12-22 Chloe H. Choi , Andrea Zanoni , Daniele E. Schiavazzi , Alison L. Marsden

This paper studies the formulation, well-posedness, and numerical solution of Bayesian inverse problems on metric graphs, in which the edges represent one-dimensional wires connecting vertices. We focus on the inverse problem of recovering…

Analysis of PDEs · Mathematics 2026-03-30 David Bolin , Wenwen Li , Daniel Sanz-Alonso

The inverse problem in Acousto-Electric tomography concerns the reconstruction of the electric conductivity in a domain from knowledge of the power density function in the interior of the body. This interior power density results from…

Numerical Analysis · Mathematics 2020-01-09 Changyou Li , Mirza Karamehmedovic , Ekaterina Sherina , Kim Knudsen

Connecting cell behavior to tissue shape and mechanics is a key challenge in the physics of morphogenesis. Cytoskeletal turnover precludes a fixed reference state, and tensions are actively generated independently of strain; so conventional…

Soft Condensed Matter · Physics 2026-05-28 Nikolas H. Claussen , Fridtjof Brauns , Boris I. Shraiman

Optimal recursive decomposition (or DR-planning) is crucial for analyzing, designing, solving or finding realizations of geometric constraint sytems. While the optimal DR-planning problem is NP-hard even for general 2D bar-joint constraint…

Computational Geometry · Computer Science 2015-07-07 Troy Baker , Meera Sitharam , Menghan Wang , Joel Willoughby

We propose a one-dimensional, nonconvex elastic constitutive model with higher gradients that can predict spontaneous fracture at a critical load via a bifurcation analysis. It overcomes the problem of discontinuous deformations without…

Analysis of PDEs · Mathematics 2021-03-17 Phoebus Rosakis , Timothy J. Healey , Ugur Alyanak