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Machine learning has revolutionized the modeling of clinical timeseries data. Using machine learning, a Deep Neural Network (DNN) can be automatically trained to learn a complex mapping of its input features for a desired task. This is…

Machine Learning · Computer Science 2024-10-15 Ryan King , Shivesh Kodali , Conrad Krueger , Tianbao Yang , Bobak J. Mortazavi

In the evolving landscape of ECG signal analysis, the challenge of limited transparency in machine learning models remains a significant barrier to their effective integration into clinical practice. This study addresses this issue by…

Signal Processing · Electrical Eng. & Systems 2024-12-09 Toygar Tanyel , Sezgin Atmaca , Kaan Gökçe , M. Yiğit Balık , Arda Güler , Emre Aslanger , İlkay Öksüz

The widespread application of Electronic Health Records (EHR) data in the medical field has led to early successes in disease risk prediction using deep learning methods. These methods typically require extensive data for training due to…

Machine Learning · Computer Science 2024-11-28 Shibo Li , Hengliang Cheng , Weihua Li

Accurate prediction of clinical outcomes using Electronic Health Records (EHRs) is critical for early intervention, efficient resource allocation, and improved patient care. EHRs contain multimodal data, including both structured data and…

Machine Learning · Computer Science 2025-08-29 Rituparna Datta , Jiaming Cui , Zihan Guan , Vishal G. Reddy , Joshua C. Eby , Gregory Madden , Rupesh Silwal , Anil Vullikanti

With the recent availability of Electronic Health Records (EHR) and great opportunities they offer for advancing medical informatics, there has been growing interest in mining EHR for improving quality of care. Disease diagnosis due to its…

Artificial Intelligence · Computer Science 2018-04-24 Anahita Hosseini , Ting Chen , Wenjun Wu , Yizhou Sun , Majid Sarrafzadeh

The electrocardiogram (ECG) is a fundamental tool in cardiovascular diagnostics due to its powerful and non-invasive nature. One of the most critical usages is to determine whether more detailed examinations are necessary, with users…

Artificial Intelligence · Computer Science 2025-04-15 Junichiro Takahashi , JingChuan Guan , Masataka Sato , Kaito Baba , Kazuto Haruguchi , Daichi Nagashima , Satoshi Kodera , Norihiko Takeda

The event-based model (EBM) for data-driven disease progression modeling estimates the sequence in which biomarkers for a disease become abnormal. This helps in understanding the dynamics of disease progression and facilitates early…

Computer Vision and Pattern Recognition · Computer Science 2017-02-22 Vikram Venkatraghavan , Esther Bron , Wiro Niessen , Stefan Klein

Electronic health record (EHR) data is sparse and irregular as it is recorded at irregular time intervals, and different clinical variables are measured at each observation point. In this work, we propose a multi-view features integration…

Machine Learning · Computer Science 2021-01-27 Yurim Lee , Eunji Jun , Heung-Il Suk

Intensive care units (ICU) are increasingly looking towards machine learning for methods to provide online monitoring of critically ill patients. In machine learning, online monitoring is often formulated as a supervised learning problem.…

Machine Learning · Computer Science 2021-09-17 Hugo Yèche , Gideon Dresdner , Francesco Locatello , Matthias Hüser , Gunnar Rätsch

In medical time series disease diagnosis, two key challenges are identified. First, the high annotation cost of medical data leads to overfitting in models trained on label-limited, single-center datasets. To address this, we propose…

Human-Computer Interaction · Computer Science 2025-08-08 Yifan Wang , Hongfeng Ai , Ruiqi Li , Maowei Jiang , Ruiyuan Kang , Jiahua Dong , Cheng Jiang , Chenzhong Li

An energy-based model (EBM) is a popular generative framework that offers both explicit density and architectural flexibility, but training them is difficult since it is often unstable and time-consuming. In recent years, various training…

Machine Learning · Computer Science 2023-03-07 Hankook Lee , Jongheon Jeong , Sejun Park , Jinwoo Shin

Objective: To transform heterogeneous clinical data from electronic health records into clinically meaningful constructed features using data driven method that rely, in part, on temporal relations among data. Materials and Methods: The…

Machine Learning · Computer Science 2017-06-22 Edward Choi , Andy Schuetz , Walter F. Stewart , Jimeng Sun

The mining of adverse drug events (ADEs) is pivotal in pharmacovigilance, enhancing patient safety by identifying potential risks associated with medications, facilitating early detection of adverse events, and guiding regulatory…

Artificial Intelligence · Computer Science 2024-10-04 Pranab Sahoo , Ayush Kumar Singh , Sriparna Saha , Aman Chadha , Samrat Mondal

Modern health data science applications leverage abundant molecular and electronic health data, providing opportunities for machine learning to build statistical models to support clinical practice. Time-to-event analysis, also called…

Electronic medical records (EMRs) supports the development of machine learning algorithms for predicting disease incidence, patient response to treatment, and other healthcare events. But insofar most algorithms have been centralized,…

Machine Learning · Computer Science 2019-03-25 Li Huang , Dianbo Liu

In medical time series disease diagnosis, two key challenges are identified.First, the high annotation cost of medical data leads to overfitting in models trained on label-limited, single-center datasets. To address this, we propose…

Machine Learning · Computer Science 2025-01-31 Yifan Wang , Hongfeng Ai , Ruiqi Li , Maowei Jiang , Cheng Jiang , Chenzhong Li

Deep learning models exhibit state-of-the-art performance for many predictive healthcare tasks using electronic health records (EHR) data, but these models typically require training data volume that exceeds the capacity of most healthcare…

Machine Learning · Computer Science 2018-10-24 Edward Choi , Cao Xiao , Walter F. Stewart , Jimeng Sun

We propose Deep Longitudinal Targeted Minimum Loss-based Estimation (Deep LTMLE), a novel approach to estimate the counterfactual mean of outcome under dynamic treatment policies in longitudinal problem settings. Our approach utilizes a…

Machine Learning · Statistics 2025-06-09 Toru Shirakawa , Yi Li , Yulun Wu , Sky Qiu , Yuxuan Li , Mingduo Zhao , Hiroyasu Iso , Mark van der Laan

In this work we addressed the problem of capturing sequential information contained in longitudinal electronic health records (EHRs). Clinical notes, which is a particular type of EHR data, are a rich source of information and practitioners…

Computation and Language · Computer Science 2020-10-27 Andrey Kormilitzin , Nemanja Vaci , Qiang Liu , Hao Ni , Goran Nenadic , Alejo Nevado-Holgado

Patients who suffer an acute coronary syndrome are at elevated risk for adverse cardiovascular events such as myocardial infarction and cardiovascular death. Accurate assessment of this risk is crucial to their course of care. We focus on…

Machine Learning · Computer Science 2020-03-26 Divya Shanmugam , Davis Blalock , John Guttag