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Pre-trained language models (PLMs) have been the de facto paradigm for most natural language processing (NLP) tasks. This also benefits biomedical domain: researchers from informatics, medicine, and computer science (CS) communities propose…

Computation and Language · Computer Science 2023-07-18 Benyou Wang , Qianqian Xie , Jiahuan Pei , Zhihong Chen , Prayag Tiwari , Zhao Li , Jie fu

Large-scale clinical data is invaluable to driving many computational scientific advances today. However, understandable concerns regarding patient privacy hinder the open dissemination of such data and give rise to suboptimal siloed…

Computation and Language · Computer Science 2019-05-23 Oren Melamud , Chaitanya Shivade

This paper presents a comprehensive evaluation of cost-efficient Large Language Models (LLMs) for diverse biomedical tasks spanning both text and image modalities. We evaluated a range of closed-source and open-source LLMs on tasks such as…

Computation and Language · Computer Science 2025-07-21 Israt Jahan , Md Tahmid Rahman Laskar , Chun Peng , Jimmy Huang

Large language models (LLMs) holds significant promise in achieving general medication recommendation systems owing to their comprehensive interpretation of clinical notes and flexibility to medication encoding. We evaluated both…

Information Retrieval · Computer Science 2025-08-05 Zihao Zhao , Chenxiao Fan , Junlong Liu , Zheng Wang , Xiangnan He , Chongming Gao , Juan Li , Fuli Feng

Natural language processing (NLP) is a key technology to extract important patient information from clinical narratives to support healthcare applications. The rapid development of large language models (LLMs) has revolutionized many NLP…

Computation and Language · Computer Science 2025-09-08 Cheng Peng , Xinyu Dong , Mengxian Lyu , Daniel Paredes , Yaoyun Zhang , Yonghui Wu

Fine-tuning of Large Language Models (LLMs) for downstream tasks, performed on domain-specific data has shown significant promise. However, commercial use of such LLMs is limited by the high computational cost required for their deployment…

Computation and Language · Computer Science 2025-03-06 Boris Nazarov , Darya Frolova , Yackov Lubarsky , Alexei Gaissinski , Pavel Kisilev

This paper investigates the challenges of developing large language models (LLMs) proficient in both multilingual understanding and medical knowledge. We demonstrate that simply translating medical data does not guarantee strong performance…

Computation and Language · Computer Science 2025-01-20 Nada Saadi , Tathagata Raha , Clément Christophe , Marco AF Pimentel , Ronnie Rajan , Praveen K Kanithi

Pre-trained Large Language Models (LLMs) often struggle on out-of-domain datasets like healthcare focused text. We explore specialized pre-training to adapt smaller LLMs to different healthcare datasets. Three methods are assessed:…

Computation and Language · Computer Science 2024-04-01 Niall Taylor , Dan Schofield , Andrey Kormilitzin , Dan W Joyce , Alejo Nevado-Holgado

A long-running goal of the clinical NLP community is the extraction of important variables trapped in clinical notes. However, roadblocks have included dataset shift from the general domain and a lack of public clinical corpora and…

Computation and Language · Computer Science 2022-12-01 Monica Agrawal , Stefan Hegselmann , Hunter Lang , Yoon Kim , David Sontag

Large language models have exhibited exceptional performance on various Natural Language Processing (NLP) tasks, leveraging techniques such as the pre-training, and instruction fine-tuning. Despite these advances, their effectiveness in…

Computation and Language · Computer Science 2023-06-19 Guangyu Wang , Guoxing Yang , Zongxin Du , Longjun Fan , Xiaohu Li

Large Language Models (LLMs) demonstrate remarkable versatility in various NLP tasks but encounter distinct challenges in biomedical due to the complexities of language and data scarcity. This paper investigates LLMs application in the…

Computation and Language · Computer Science 2024-07-12 Masoud Monajatipoor , Jiaxin Yang , Joel Stremmel , Melika Emami , Fazlolah Mohaghegh , Mozhdeh Rouhsedaghat , Kai-Wei Chang

Contextual word embedding models such as ELMo (Peters et al., 2018) and BERT (Devlin et al., 2018) have dramatically improved performance for many natural language processing (NLP) tasks in recent months. However, these models have been…

Computation and Language · Computer Science 2019-06-24 Emily Alsentzer , John R. Murphy , Willie Boag , Wei-Hung Weng , Di Jin , Tristan Naumann , Matthew B. A. McDermott

Continual learning (CL) in large language models (LLMs) is an evolving domain that focuses on developing efficient and sustainable training strategies to adapt models to emerging knowledge and achieve robustness in dynamic environments. Our…

Computation and Language · Computer Science 2025-02-13 Çağatay Yıldız , Nishaanth Kanna Ravichandran , Nitin Sharma , Matthias Bethge , Beyza Ermis

A key challenge in training neural networks for a given medical imaging task is often the difficulty of obtaining a sufficient number of manually labeled examples. In contrast, textual imaging reports, which are often readily available in…

Machine Learning · Computer Science 2022-01-31 Gongbo Liang , Connor Greenwell , Yu Zhang , Xiaoqin Wang , Ramakanth Kavuluru , Nathan Jacobs

Large Language Models (LLMs) have demonstrated surprising performance across various natural language processing tasks. Recently, medical LLMs enhanced with domain-specific knowledge have exhibited excellent capabilities in medical…

Computation and Language · Computer Science 2024-09-24 Jinqiang Wang , Huansheng Ning , Yi Peng , Qikai Wei , Daniel Tesfai , Wenwei Mao , Tao Zhu , Runhe Huang

Text simplification has emerged as an increasingly useful application of AI for bridging the communication gap in specialized fields such as medicine, where the lexicon is often dominated by technical jargon and complex constructs. Despite…

Computation and Language · Computer Science 2023-10-27 Lorenzo Jaime Yu Flores , Heyuan Huang , Kejian Shi , Sophie Chheang , Arman Cohan

Large Language Models (LLMs) rely on various decoding strategies to generate text, and these choices can significantly affect output quality. In healthcare, where accuracy is critical, the impact of decoding strategies remains…

Computation and Language · Computer Science 2025-08-20 Oriana Presacan , Alireza Nik , Vajira Thambawita , Bogdan Ionescu , Michael Riegler

The increasing volume and complexity of clinical documentation in Electronic Medical Records systems pose significant challenges for clinical coders, who must mentally process and summarise vast amounts of clinical text to extract essential…

Computation and Language · Computer Science 2024-09-25 Bokang Bi , Leibo Liu , Sanja Lujic , Louisa Jorm , Oscar Perez-Concha

Large Language Models (LLMs) have demonstrated significant potential in medicine, with many studies adapting them through continued pre-training or fine-tuning on medical data to enhance domain-specific accuracy and safety. However, a key…

The text of clinical notes can be a valuable source of patient information and clinical assessments. Historically, the primary approach for exploiting clinical notes has been information extraction: linking spans of text to concepts in a…

Computation and Language · Computer Science 2019-06-11 Sarah Wiegreffe , Edward Choi , Sherry Yan , Jimeng Sun , Jacob Eisenstein