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Scanning transmission electron microscopy (STEM) has been extensively used for imaging complex materials down to atomic resolution. The most commonly employed STEM modality, annular dark-field imaging, produces easily-interpretable…

We introduce the EMC algorithm for reconstructing a particle's 3D diffraction intensity from very many photon shot-noise limited 2D measurements, when the particle orientation in each measurement is unknown. The algorithm combines a…

Data Analysis, Statistics and Probability · Physics 2010-03-04 Duane Ne-Te Loh , Veit Elser

Cryo-electron microscopy (cryo-EM) has become a tool of fundamental importance in structural biology, helping us understand the basic building blocks of life. The algorithmic challenge of cryo-EM is to jointly estimate the unknown 3D poses…

Computer Vision and Pattern Recognition · Computer Science 2022-09-01 Axel Levy , Frédéric Poitevin , Julien Martel , Youssef Nashed , Ariana Peck , Nina Miolane , Daniel Ratner , Mike Dunne , Gordon Wetzstein

A new method has been developed for the correction of the distortions and/or enhanced phase differentiation in Electron Backscatter Diffraction (EBSD) data. Using a multi-modal data approach, the method uses segmented images of the phase of…

Data Analysis, Statistics and Probability · Physics 2019-03-11 Marie-Agathe Charpagne , Florian Strub , Tresa M. Pollock

Half of wavefunction information is undetected by conventional transmission electron microscopy (CTEM) as only the intensity, and not the phase, of an image is recorded. Following successful applications of deep learning to optical hologram…

Image and Video Processing · Electrical Eng. & Systems 2020-01-31 Jeffrey M. Ede , Jonathan J. P. Peters , Jeremy Sloan , Richard Beanland

The dynamics of biomolecules are crucial for our understanding of their functioning in living systems. However, current 3D imaging techniques, such as cryogenic electron microscopy (cryo-EM), require freezing the sample, which limits the…

Quantitative Methods · Quantitative Biology 2023-08-24 Enze Ye , Yuhang Wang , Hong Zhang , Yiqin Gao , Huan Wang , He Sun

PURPOSE: To correct line-to-line delays and phase errors in echo-planar imaging (EPI). THEORY AND METHODS: EPI- trajectory auto-corrected image reconstruction (EPI-TrACR) is an iterative maximum-likelihood technique that exploits data…

Medical Physics · Physics 2017-06-27 Julianna D. Ianni , E. Brian Welch , William A. Grissom

We consider the imaging problem of the reconstruction of a three-dimensional object via optical diffraction tomography under the assumptions of the Born approximation. Our focus lies in the situation that a rigid object performs an…

Numerical Analysis · Mathematics 2024-07-11 Robert Beinert , Michael Quellmalz

Cryo-electron microscopy (cryo-EM) has recently emerged as a powerful tool for obtaining three-dimensional (3D) structures of biological macromolecules in native states. A minimum cryo-EM image data set for deriving a meaningful…

Applications · Statistics 2014-04-28 Ting-Li Chen , Dai-Ni Hsieh , Hung Hung , I-Ping Tu , Pei-Shien Wu , Yi-Ming Wu , Wei-Hau Chang , Su-Yun Huang

Phase recovery from intensity-only measurements forms the heart of coherent imaging techniques and holography. Here we demonstrate that a neural network can learn to perform phase recovery and holographic image reconstruction after…

Computer Vision and Pattern Recognition · Computer Science 2017-12-13 Yair Rivenson , Yibo Zhang , Harun Gunaydin , Da Teng , Aydogan Ozcan

In this report, we applied expectation and maximization (EM) method described by Philips et al [1] to recover two-dimensional (2D) structure from multiple sparse signal images in random orientation. The detailed derivation of EM algorithm…

Data Analysis, Statistics and Probability · Physics 2017-01-12 Yun Zhao

Ghost imaging leverages a single-pixel detector with no spatial resolution to acquire object echo intensity signals, which are correlated with illumination patterns to reconstruct an image. This architecture inherently mitigates scattering…

Optics · Physics 2025-12-01 Yue-Gang Li , Ze Zheng , Jun-jie Wang , Ming He , Jianping Fan , Tailong Xiao , Guihua Zeng

Simulations of quantum matter rely mainly on Kohn-Sham density functional theory (DFT), which often fails for strongly correlated systems. Quantum embedding (QE) theories address this limitation by mapping the system onto an auxiliary…

Strongly Correlated Electrons · Physics 2025-12-29 Samuele Giuli , Hasanat Hasan , Benedikt Kloss , Marius S. Frank , Tsung-Han Lee , Olivier Gingras , Yong-Xin Yao , Nicola Lanatà

A standardized phase retrieval algorithm is presented and applied to an industry-grade high-energy ultrashort pulsed laser to uncover its spatial phase distribution. We describe in detail how to modify the well-known algorithm in order to…

We present eMAGPIE (extended Multilevel-Adaptive-Guided Ptychographic Iterative Engine), a stochastic multigrid method for blind ptychographic phase retrieval that jointly recovers the object and the probe. We recast the task as the…

Numerical Analysis · Mathematics 2025-11-04 Borong Zhang , Junjing Deng , Yi Jiang , Zichao Wendy Di

Cryo-electron microscopy (cryo-EM) has become a central tool for high-resolution structural biology, yet the massive scale of datasets (often exceeding 100k particle images) renders 3D reconstruction both computationally expensive and…

Computer Vision and Pattern Recognition · Computer Science 2025-10-03 Huaizhi Qu , Xiao Wang , Gengwei Zhang , Jie Peng , Tianlong Chen

By means of numerical simulations, we demonstrate the innovative use of computational ghost imaging in transmission electron microscopy to retrieve images with a resolution that overcomes the limitations imposed by coherent aberrations. The…

Instrumentation and Detectors · Physics 2024-11-20 P. Rosi , L. Viani , E. Rotunno , S. Frabboni , A. H. Tavabi , R. E. Dunin-Borkowski , A. Roncaglia , V. Grillo

Sparse modeling is one of the efficient techniques for imaging that allows recovering lost information. In this paper, we present a novel iterative phase-retrieval algorithm using a sparse representation of the object amplitude and phase.…

Computer Vision and Pattern Recognition · Computer Science 2011-08-17 Artem Migukin , Vladimir Katkovnik , Jaakko Astola

Nyquist ghost artifacts in EPI are originated from phase mismatch between the even and odd echoes. However, conventional correction methods using reference scans often produce erroneous results especially in high-field MRI due to the…

Computer Vision and Pattern Recognition · Computer Science 2019-10-16 Juyoung Lee , Yoseob Han , Jae-Kyun Ryu , Jang-Yeon Park , Jong Chul Ye

High-fidelity electron microscopy simulations required for quantitative crystal structure refinements face a fundamental challenge: while physical interactions are well-described theoretically, real-world experimental effects are…