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Medical vision foundation models remain limited in downstream tasks, particularly volumetric medical image segmentation. While fine-tuning on labeled target-domain data improves performance, existing approaches typically rely on randomly…

Image and Video Processing · Electrical Eng. & Systems 2026-05-07 Jin Yang , Daniel S. Marcus , Aristeidis Sotiras

Existing deep learning methods for remote sensing image fusion often suffer from poor generalization when applied to unseen datasets due to the limited availability of real training data and the domain gap between different satellite…

Computer Vision and Pattern Recognition · Computer Science 2025-12-03 Yongchuan Cui , Peng Liu , Yi Zeng

Deep neural networks have been extensively studied for undersampled MRI reconstruction. While achieving state-of-the-art performance, they are trained and deployed specifically for one anatomy with limited generalization ability to another…

Computer Vision and Pattern Recognition · Computer Science 2021-03-10 Xinwen Liu , Jing Wang , Feng Liu , S. Kevin Zhou

Foundation models for computational pathology are expected to facilitate the development of high-performing, generalisable deep learning systems. However, in addition to biologically relevant features, current foundation models also capture…

Achieving domain generalization in medical imaging poses a significant challenge, primarily due to the limited availability of publicly labeled datasets in this domain. This limitation arises from concerns related to data privacy and the…

Image and Video Processing · Electrical Eng. & Systems 2024-07-23 Ahmed Radwan , Islam Osman , Mohamed S. Shehata

In this paper, we explore the possibility of building a unified foundation model that can be adapted to both vision-only and text-only tasks. Starting from BERT and ViT, we design a unified transformer consisting of modality-specific…

Computer Vision and Pattern Recognition · Computer Science 2021-12-15 Qing Li , Boqing Gong , Yin Cui , Dan Kondratyuk , Xianzhi Du , Ming-Hsuan Yang , Matthew Brown

This work proposes a semantic segmentation network that produces high-quality uncertainty estimates in a single forward pass. We exploit general representations from foundation models and unlabelled datasets through a Masked Image Modeling…

Computer Vision and Pattern Recognition · Computer Science 2024-02-28 David S. W. Williams , Matthew Gadd , Paul Newman , Daniele De Martini

While pathology foundation models have transformed cancer image analysis, they often lack integration with molecular data at single-cell resolution, limiting their utility for precision oncology. Here, we present PAST, a pan-cancer…

Quantitative Methods · Quantitative Biology 2025-07-10 Changchun Yang , Haoyang Li , Yushuai Wu , Yilan Zhang , Yifeng Jiao , Yu Zhang , Rihan Huang , Yuan Cheng , Yuan Qi , Xin Guo , Xin Gao

While emerging 3D medical foundation models are envisioned as versatile tools with offer general-purpose capabilities, their validation remains largely confined to regional and structural imaging, leaving a significant modality discrepancy…

Computer Vision and Pattern Recognition · Computer Science 2026-02-10 Yichi Zhang , Feiyang Xiao , Le Xue , Wenbo Zhang , Gang Feng , Chenguang Zheng , Yuan Qi , Yuan Cheng , Zixin Hu

Whole slide images, with their gigapixel-scale panoramas of tissue samples, are pivotal for precise disease diagnosis. However, their analysis is hindered by immense data size and scarce annotations. Existing MIL methods face challenges due…

Computer Vision and Pattern Recognition · Computer Science 2026-02-26 Weiyi Wu , Xinwen Xu , Chongyang Gao , Xingjian Diao , Siting Li , Jiang Gui

The recent surge of foundation models in computer vision and natural language processing opens up perspectives in utilizing multi-modal clinical data to train large models with strong generalizability. Yet pathological image datasets often…

Computer Vision and Pattern Recognition · Computer Science 2023-07-28 Yunkun Zhang , Jin Gao , Mu Zhou , Xiaosong Wang , Yu Qiao , Shaoting Zhang , Dequan Wang

Radiological images such as computed tomography (CT) and X-rays render anatomy with intrinsic structures. Being able to reliably locate the same anatomical structure across varying images is a fundamental task in medical image analysis. In…

Computer Vision and Pattern Recognition · Computer Science 2023-10-24 Ke Yan , Jinzheng Cai , Dakai Jin , Shun Miao , Dazhou Guo , Adam P. Harrison , Youbao Tang , Jing Xiao , Jingjing Lu , Le Lu

Foundation models have substantially advanced computational pathology by learning transferable visual representations from large histological datasets, yet their performance varies widely across tasks due to differences in training data…

Computer Vision and Pattern Recognition · Computer Science 2026-02-16 Wenhui Lei , Yusheng Tan , Anqi Li , Hanyu Chen , Hengrui Tian , Ruiying Li , Zhengqun Jiang , Fang Yan , Xiaofan Zhang , Shaoting Zhang

Medical vision foundational models are used for a wide variety of tasks, including medical image segmentation and registration. This work evaluates the ability of these models to predict disease progression using a simple linear probe. We…

Image and Video Processing · Electrical Eng. & Systems 2025-03-24 Basar Demir , Soumitri Chattopadhyay , Thomas Hastings Greer , Boqi Chen , Marc Niethammer

Breast cancer is the most common cancer type in women worldwide. Early detection and appropriate treatment can significantly reduce its impact. While histopathology examinations play a vital role in rapid and accurate diagnosis, they often…

Computer Vision and Pattern Recognition · Computer Science 2026-04-28 Nematollah Saeidi , Hossein Karshenas , Bijan Shoushtarian , Sepideh Hatamikia , Ramona Woitek , Amirreza Mahbod

Domain shift is a major problem for deploying deep networks in clinical practice. Network performance drops significantly with (target) images obtained differently than its (source) training data. Due to a lack of target label data, most…

Computer Vision and Pattern Recognition · Computer Science 2020-07-08 Yufan He , Aaron Carass , Lianrui Zuo , Blake E. Dewey , Jerry L. Prince

Multimodal pathological images are usually in clinical diagnosis, but computer vision-based multimodal image-assisted diagnosis faces challenges with modality fusion, especially in the absence of expert-annotated data. To achieve the…

Computer Vision and Pattern Recognition · Computer Science 2025-09-24 Qinghua Lin , Guang-Hai Liu , Zuoyong Li , Yang Li , Yuting Jiang , Xiang Wu

Recently, masked image modeling (MIM) has gained considerable attention due to its capacity to learn from vast amounts of unlabeled data and has been demonstrated to be effective on a wide variety of vision tasks involving natural images.…

Computer Vision and Pattern Recognition · Computer Science 2022-08-25 Zekai Chen , Devansh Agarwal , Kshitij Aggarwal , Wiem Safta , Samit Hirawat , Venkat Sethuraman , Mariann Micsinai Balan , Kevin Brown

Despite significant advances in deep learning for image and video segmentation, existing models continue to face challenges in cross-domain adaptability and generalization. Image and video segmentation are fundamental tasks in computer…

Computer Vision and Pattern Recognition · Computer Science 2025-03-18 Zhang Jiaxing , Tang Hao

Models based on U-like structures have improved the performance of medical image segmentation. However, the single-layer decoder structure of U-Net is too "thin" to exploit enough information, resulting in large semantic differences between…

Image and Video Processing · Electrical Eng. & Systems 2023-09-08 Haoyuan Chen , Yufei Han , Pin Xu , Yanyi Li , Kuan Li , Jianping Yin
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