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Objectives: Magnetic resonance elastography (MRE) is a noninvasive technique for assessing the viscoelastic properties of soft biological tissues in vivo, with potential relevance for pediatric tumor evaluation. This study aimed to evaluate…

Understanding corneal stiffness is valuable for improving refractive surgery, detecting corneal abnormalities, and assessing intraocular pressure. However, accurately measuring the elastic properties, particularly the tensile and shear…

Medical Physics · Physics 2023-08-11 Guo-Yang Li , Xu Feng , Seok-Hyun Yun

Purpose: To demonstrate the feasibility of performing in vivo imaging and quantitative relaxation mapping of soft and hard tissues using a low-cost, portable MRI scanner, and to establish the methodological foundations for zero echo time…

Major biological discoveries have been made by interrogating living organisms with light. However, the limited penetration of unscattered photons within biological tissues severely limits the depth range covered by optical methods.…

Optical tweezers are an invaluable tool for non-contact trapping and micro-manipulation, but their ability to facilitate high-throughput volumetric microrheology of biological samples for mechanobiology research is limited by the precise…

Instrumentation and Detectors · Physics 2021-04-07 Nichaluk Leartprapun , Rishyashring R. Iyer , Gavrielle R. Untracht , Jeffrey A. Mulligan , Steven G. Adie

When introducing physics-constrained deep learning solutions to the volumetric super-resolution of scientific data, the training is challenging to converge and always time-consuming. We propose a new hierarchical sampling method based on…

Computational Physics · Physics 2023-06-09 Xinjie Wang , Maoquan Sun , Yundong Guo , Chunxin Yuan , Xiang Sun , Zhiqiang Wei , Xiaogang Jin

Structural and compositional inhomogeneity is common in zeolites and considerably affects their properties. Conventional transmission electron microscopy (TEM) cannot provide sufficient information on local structures in zeolites due to the…

This article describes a novel quasi-real time system for quantitative and volumetric measurement of tissue elasticity in the prostate. Tissue elasticity is computed by using a local frequency estimator to measure the three dimensional…

The distinction between malignant and benign tumors is essential to the treatment of cancer. The tissue's elasticity can be used as an indicator for the required tissue characterization. Optical coherence elastography (OCE) probes have been…

Image and Video Processing · Electrical Eng. & Systems 2021-09-21 Robin Mieling , Johanna Sprenger , Sarah Latus , Lennart Bargsten , Alexander Schlaefer

Accurate assessment of stiffness distribution is essential due to the critical role of single cell mechanobiology in the regulation of many vital cellular processes such as proliferation, adhesion, migration, and motility. Cell stiffness is…

Dynamic elastography is a widely used, safe, convenient, and cost-effective method to aid in medical diagnosis. It visualizes the wave field propagating through living tissues and quantitatively determines the wave propagation speed from…

Analysis of PDEs · Mathematics 2026-04-15 Yu Jiang , Ching-Lung Lin , Gen Nakamura

Given its real-time capability to quantify mechanical tissue properties, ultrasound shear wave elastography holds significant promise in clinical musculoskeletal imaging. However, existing shear wave elastography methods fall short in…

Medical Physics · Physics 2024-06-07 Bryan J. Ranger , Kevin M. Moerman , Micha Feigin , Hugh M. Herr , Brian W. Anthony

In this chapter a general mathematical model of Optical Coherence Tomography (OCT) is presented on the basis of the electromagnetic theory. OCT produces high resolution images of the inner structure of biological tissues. Images are…

Numerical Analysis · Mathematics 2016-04-19 Peter Elbau , Leonidas Mindrinos , Otmar Scherzer

In this paper, we propose mathematical models for reconstructing the optical flow in time-harmonic elastography. In this image acquisition technique, the object undergoes a special time-harmonic oscillation with known frequency so that only…

Numerical Analysis · Mathematics 2025-01-14 Oleh Melnyk , Michael Quellmalz , Gabriele Steidl , Noah Jaitner , Jakob Jordan , Ingolf Sack

A variant of compression optical coherence elastography for mapping relative tissue stiffness is reported. Unlike conventionally discussed displacement-based (DB) elastorgaphy, in which the decrease in the cross-correlation is a negative…

Bioelectronic implants with soft mechanics, biocompatibility, and excellent electrical performance enable biomedical implants to record electrophysiological signals and execute interventions within internal organs, promising to…

Magnetic Resonance Elastography (MRE) has become an essential tool in assessing the mechanical properties of soft tissues in-vivo, prompting significant progress in new inversion algorithms. This creates a need for a benchmarking framework…

Numerical Analysis · Mathematics 2026-04-06 Yashasvi Verma , Jakob Schattenfroh , Ingolf Sack , Silvia Budday , Paul Steinmann , Luca Heltai

Ultrasound shear wave elasticity imaging is a valuable tool for quantifying the elastic properties of tissue. Typically, the shear wave velocity is derived and mapped to an elasticity value, which neglects information such as the shape of…

Image and Video Processing · Electrical Eng. & Systems 2022-04-29 Maximilian Neidhardt , Marcel Bengs , Sarah Latus , Stefan Gerlach , Christian J. Cyron , Johanna Sprenger , Alexander Schlaefer

3D ultrasound imaging provides more spatial information compared to conventional 2D frames by considering the volumes of data. One of the main bottlenecks of 3D imaging is the long data acquisition time which reduces practicality and can…

Purpose: To propose and evaluate an accelerated $T_{1\rho}$ quantification method that combines $T_{1\rho}$-weighted fast spin echo (FSE) images and proton density (PD)-weighted anatomical FSE images, leveraging deep learning models for…

Image and Video Processing · Electrical Eng. & Systems 2025-08-06 Junru Zhong , Chaoxing Huang , Ziqiang Yu , Fan Xiao , Siyue Li , Tim-Yun Michael Ong , Ki-Wai Kevin Ho , Queenie Chan , James F. Griffith , Weitian Chen