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Background: With the ever-increasing amount of medical imaging data, the demand for algorithms to assist clinicians has amplified. Unsupervised anomaly detection (UAD) models promise to aid in the crucial first step of disease detection.…

Unsupervised Anomaly Detection (UAD) aims to identify abnormal regions by establishing correspondences between test images and normal templates. Existing methods primarily rely on image reconstruction or template retrieval but face a…

Computer Vision and Pattern Recognition · Computer Science 2026-02-24 Mingxiu Cai , Zhe Zhang , Gaochang Wu , Tianyou Chai , Xiatian Zhu

Unsupervised Out-of-Distribution (OOD) detection consists in identifying anomalous regions in images leveraging only models trained on images of healthy anatomy. An established approach is to tokenize images and model the distribution of…

Computer Vision and Pattern Recognition · Computer Science 2023-08-04 Sergio Naval Marimont , Vasilis Siomos , Giacomo Tarroni

Unsupervised anomaly detection (UAD) plays a crucial role in neuroimaging for identifying deviations from healthy subject data and thus facilitating the diagnosis of neurological disorders. In this work, we focus on Bayesian flow networks…

Computer Vision and Pattern Recognition · Computer Science 2025-10-21 Hugues Roy , Reuben Dorent , Ninon Burgos

Data-driven machine learning has made significant strides in medical image analysis. However, most existing methods are tailored to specific modalities and assume a particular resolution (often isotropic). This limits their generalizability…

Image and Video Processing · Electrical Eng. & Systems 2025-01-24 Peirong Liu , Ana Lawry Aguila , Juan E. Iglesias

Current unsupervised anomaly localization approaches rely on generative models to learn the distribution of normal images, which is later used to identify potential anomalous regions derived from errors on the reconstructed images. However,…

Image and Video Processing · Electrical Eng. & Systems 2022-07-13 Julio Silva-Rodríguez , Valery Naranjo , Jose Dolz

Out-of-distribution (OOD) detection is crucial for safely deploying automated medical image analysis systems, as abnormal patterns in images could hamper their performance. However, OOD detection in medical imaging remains an open…

Image and Video Processing · Electrical Eng. & Systems 2025-09-18 Evi M. C. Huijben , Sina Amirrajab , Josien P. W. Pluim

The core challenge in unsupervised anomaly detection is identifying abnormal patterns without prior knowledge of their characteristics. While existing methods have addressed aspects of this problem, they often struggle to learn a robust…

Machine Learning · Computer Science 2026-05-12 Prithul Sarker , Sushmita Sarker , Nicholas G. Murray , Alireza Tavakkoli

Monitoring diseases that affect the brain's structural integrity requires automated analysis of magnetic resonance (MR) images, e.g., for the evaluation of volumetric changes. However, many of the evaluation tools are optimized for…

Recent works demonstrate the effectiveness of diffusion models as unsupervised solvers for inverse imaging problems. Sparse-view computed tomography (CT) has greatly benefited from these advancements, achieving improved generalization…

Image and Video Processing · Electrical Eng. & Systems 2025-05-28 Ezgi Demircan-Tureyen , Felix Lucka , Tristan van Leeuwen

Purpose. Brain Magnetic Resonance Images (MRIs) are essential for the diagnosis of neurological diseases. Recently, deep learning methods for unsupervised anomaly detection (UAD) have been proposed for the analysis of brain MRI. These…

Image and Video Processing · Electrical Eng. & Systems 2021-09-15 Marcel Bengs , Finn Behrendt , Julia Krüger , Roland Opfer , Alexander Schlaefer

Unsupervised anomaly detection plays a pivotal role in industrial defect inspection and medical image analysis, with most methods relying on the reconstruction framework. However, these methods may suffer from over-generalization, enabling…

Computer Vision and Pattern Recognition · Computer Science 2026-03-25 Wei Luo , Peng Xing , Yunkang Cao , Haiming Yao , Weiming Shen , Zechao Li

Reconstruction-based anomaly detection via denoising diffusion model has limitations in determining appropriate noise parameters that can degrade anomalies while preserving normal characteristics. Also, normal regions can fluctuate…

Computer Vision and Pattern Recognition · Computer Science 2025-08-20 Eunwoo Kim , Un Yang , Cheol Lae Roh , Stefano Ermon

This review explores anomaly localization in medical images using denoising diffusion models. After providing a brief methodological background of these models, including their application to image reconstruction and their conditioning…

Image and Video Processing · Electrical Eng. & Systems 2025-12-15 Cosmin I. Bercea , Philippe C. Cattin , Julia A. Schnabel , Julia Wolleb

Anomaly detection (AD) is the machine learning task of identifying highly discrepant abnormal samples by solely relying on the consistency of the normal training samples. Under the constraints of a distribution shift, the assumption that…

Machine Learning · Computer Science 2023-12-25 João B. S. Carvalho , Mengtao Zhang , Robin Geyer , Carlos Cotrini , Joachim M. Buhmann

The recent prevalence of deep neural networks has lead semantic segmentation networks to achieve human-level performance in the medical field when sufficient training data is provided. Such networks however fail to generalize when tasked…

Computer Vision and Pattern Recognition · Computer Science 2023-08-01 Serban Stan , Mohammad Rostami

Anomaly detection is the process of identifying atypical data samples that significantly deviate from the majority of the dataset. In the realm of clinical screening and diagnosis, detecting abnormalities in medical images holds great…

Computer Vision and Pattern Recognition · Computer Science 2023-10-11 Xianyao Hu , Congming Jin

Anomaly detection (AD), separating anomalies from normal data, has many applications across domains, from security to healthcare. While most previous works were shown to be effective for cases with fully or partially labeled data, that…

Machine Learning · Computer Science 2022-08-08 Jinsung Yoon , Kihyuk Sohn , Chun-Liang Li , Sercan O. Arik , Chen-Yu Lee , Tomas Pfister

Congenital uterine anomalies (CUAs) can lead to infertility, miscarriage, preterm birth, and an increased risk of pregnancy complications. Compared to traditional 2D ultrasound (US), 3D US can reconstruct the coronal plane, providing a…

Computer Vision and Pattern Recognition · Computer Science 2025-09-12 Yuhao Huang , Yueyue Xu , Haoran Dou , Jiaxiao Deng , Xin Yang , Hongyu Zheng , Dong Ni

Synthesizing longitudinal medical images at controllable disease stages while preserving patient-specific anatomy is hindered by the entanglement of pathological textures and structural features. We address this challenge for ulcerative…

Computer Vision and Pattern Recognition · Computer Science 2026-05-05 Umut Dundar , Alptekin Temizel
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