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Diffusion models have achieved remarkable success in generating high-fidelity content but suffer from slow, iterative sampling, resulting in high latency that limits their use in interactive applications. We introduce DRiffusion, a parallel…

Machine Learning · Computer Science 2026-03-30 Runsheng Bai , Chengyu Zhang , Yangdong Deng

Predicting the binding structure of a small molecule ligand to a protein -- a task known as molecular docking -- is critical to drug design. Recent deep learning methods that treat docking as a regression problem have decreased runtime…

Biomolecules · Quantitative Biology 2023-02-14 Gabriele Corso , Hannes Stärk , Bowen Jing , Regina Barzilay , Tommi Jaakkola

The design of protein sequences with desired functionalities is a fundamental task in protein engineering. Deep generative methods, such as autoregressive models and diffusion models, have greatly accelerated the discovery of novel protein…

Machine Learning · Computer Science 2025-04-16 Zitai Kong , Yiheng Zhu , Yinlong Xu , Hanjing Zhou , Mingzhe Yin , Jialu Wu , Hongxia Xu , Chang-Yu Hsieh , Tingjun Hou , Jian Wu

Autoregressive models (ARMs) are hindered by slow sequential inference. While masked diffusion models (MDMs) offer a parallel alternative, they suffer from critical drawbacks: high computational overhead from precluding Key-Value (KV)…

Computation and Language · Computer Science 2026-03-06 Jia-Nan Li , Jian Guan , Wei Wu , Chongxuan Li

Diffusion-based image compression methods have achieved notable progress, delivering high perceptual quality at low bitrates. However, their practical deployment is hindered by significant inference latency and heavy computational overhead,…

Computer Vision and Pattern Recognition · Computer Science 2026-02-03 Yiwen Jia , Hao Wei , Yanhui Zhou , Chenyang Ge

An iterative method of learning has become a paradigm for training deep convolutional neural networks (DCNN). However, utilizing a non-iterative learning strategy can accelerate the training process of the DCNN and surprisingly such…

Machine Learning · Computer Science 2018-09-18 Yimin Yang , Q. M. Jonathan Wu , Xiexing Feng , Thangarajah Akilan

Denoising Diffusion Probabilistic Models have shown extraordinary ability on various generative tasks. However, their slow inference speed renders them impractical in speech synthesis. This paper proposes a linear diffusion model (LinDiff)…

Sound · Computer Science 2023-06-13 Haogeng Liu , Tao Wang , Jie Cao , Ran He , Jianhua Tao

Recent work [1] has utilized Moore-Penrose (MP) inverse in deep convolutional neural network (DCNN) learning, which achieves better generalization performance over the DCNN with a stochastic gradient descent (SGD) pipeline. However, Yang's…

Machine Learning · Computer Science 2021-01-06 Wandong Zhang , Yimin Yang , Jonathan Wu

Discrete diffusion models generate sequences by iteratively denoising samples corrupted by categorical noise, offering an appealing alternative to autoregressive decoding for structured and symbolic generation. However, standard training…

Machine Learning · Computer Science 2026-02-04 Huu Binh Ta , Michael Cardei , Alvaro Velasquez , Ferdinando Fioretto

Diffusion models have exhibited exciting capabilities in generating images and are also very promising for video creation. However, the inference speed of diffusion models is limited by the slow sampling process, restricting its use cases.…

Computer Vision and Pattern Recognition · Computer Science 2024-12-05 XiuYu Zhang , Zening Luo , Michelle E. Lu

The recent years have seen a surge of interest in methods for imaging beyond the direct line of sight. The most prominent techniques rely on time-resolved optical impulse responses, obtained by illuminating a diffuse wall with an ultrashort…

Computer Vision and Pattern Recognition · Computer Science 2020-01-30 Javier Grau Chopite , Matthias B. Hullin , Michael Wand , Julian Iseringhausen

In recent years dynamical modelling has been provided with a range of breakthrough methods to perform exact Bayesian inference. However it is often computationally unfeasible to apply exact statistical methodologies in the context of large…

Computation · Statistics 2014-12-24 Umberto Picchini , Julie Lyng Forman

Diffusion models show promising generation capability for a variety of data. Despite their high generation quality, the inference for diffusion models is still time-consuming due to the numerous sampling iterations required. To accelerate…

Computer Vision and Pattern Recognition · Computer Science 2023-10-26 Kexun Zhang , Xianjun Yang , William Yang Wang , Lei Li

Large denoising diffusion models, such as Stable Diffusion, have been trained on billions of image-caption pairs to perform text-conditioned image generation. As a byproduct of this training, these models have acquired general knowledge…

Computer Vision and Pattern Recognition · Computer Science 2025-10-07 Alexandros Graikos , Nebojsa Jojic , Dimitris Samaras

Autoregressive models have transformed protein engineering by enabling the generation of novel protein sequences beyond those found in nature. However, their sequential inference introduces significant latency, limiting their utility in…

Machine Learning · Computer Science 2025-09-29 Thomas Walton , Darin Tsui , Aryan Musharaf , Amirali Aghazadeh

While deep neural networks (NN) significantly advance image compressed sensing (CS) by improving reconstruction quality, the necessity of training current CS NNs from scratch constrains their effectiveness and hampers rapid deployment.…

Computer Vision and Pattern Recognition · Computer Science 2025-02-04 Bin Chen , Zhenyu Zhang , Weiqi Li , Chen Zhao , Jiwen Yu , Shijie Zhao , Jie Chen , Jian Zhang

Coarse-grained molecular models of proteins permit access to length and time scales unattainable by all-atom models and the simulation of processes that occur on long-time scales such as aggregation and folding. The reduced resolution…

Biomolecules · Quantitative Biology 2023-07-25 Michael S. Jones , Kirill Shmilovich , Andrew L. Ferguson

Autoregressive video models offer distinct advantages over bidirectional diffusion models in creating interactive video content and supporting streaming applications with arbitrary duration. In this work, we present Next-Frame Diffusion…

Computer Vision and Pattern Recognition · Computer Science 2025-07-08 Xinle Cheng , Tianyu He , Jiayi Xu , Junliang Guo , Di He , Jiang Bian

Probabilistic denoising diffusion models (DDMs) have set a new standard for 2D image generation. Extending DDMs for 3D content creation is an active field of research. Here, we propose TetraDiffusion, a diffusion model that operates on a…

Computer Vision and Pattern Recognition · Computer Science 2024-08-12 Nikolai Kalischek , Torben Peters , Jan D. Wegner , Konrad Schindler

Equivariant diffusion models have achieved impressive performance in 3D molecule generation. These models incorporate Euclidean symmetries of 3D molecules by utilizing an SE(3)-equivariant denoising network. However, specialized equivariant…

Machine Learning · Computer Science 2025-07-01 Yuhui Ding , Thomas Hofmann
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