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Currently, MRI-only radiotherapy (RT) eliminates some of the concerns about using CT images in RT chains such as the registration of MR images to a separate CT, extra dose delivery, and the additional cost of repeated imaging. However, one…

Medical Physics · Physics 2021-03-03 Faeze Gholamiankhah , Samaneh Mostafapour , Hossein Arabi

Electron density maps must be accurately estimated to achieve valid dose calculation in MR-only radiotherapy. The goal of this study is to assess whether two deep learning models, the conditional generative adversarial network (cGAN) and…

To enable magnetic resonance (MR)-only radiotherapy and facilitate modelling of radiation attenuation in humans, synthetic-CT (sCT) images need to be generated. Considering the application of MR-guided radiotherapy and online adaptive…

Recently, deep learning (DL)-based methods for the generation of synthetic computed tomography (sCT) have received significant research attention as an alternative to classical ones. We present here a systematic review of these methods by…

Medical Physics · Physics 2021-08-30 Maria Francesca Spadea , Matteo Maspero , Paolo Zaffino , Joao Seco

Cone beam computed tomography (CBCT) images can be used for dose calculation in adaptive radiation therapy (ART). The main challenges are the large artefacts and inaccurate Hounsfield unit (HU) values. Currently, deformed planning CT images…

Medical Physics · Physics 2019-09-04 Xiao Liang , Liyuan Chen , Dan Nguyen , Zhiguo Zhou , Xuejun Gu , Ming Yang , Jing Wang , Steve Jiang

MRI-guided radiation treatment planning is widely applied because of its superior soft-tissue contrast and no ionization radiation compared to CT-based planning. In this regard, synthetic CT (sCT) images should be generated from the…

Medical Physics · Physics 2021-05-14 Abbas Bahrami , Alireza Karimian , Hossein Arabi

Radiation therapy (RT) requires precise dose delivery over multiple fractions, with CT fundamental for treatment planning due to its electron density information. Repeated CT acquisitions impose radiation exposure and logistical burdens,…

The generation of synthetic CT (sCT) images from cone-beam CT (CBCT) data using deep learning methodologies represents a significant advancement in radiation oncology. This systematic review, following PRISMA guidelines and using the PICO…

Image and Video Processing · Electrical Eng. & Systems 2025-01-27 Alzahra Altalib , Scott McGregor , Chunhui Li , Alessandro Perelli

Purpose: This study assessed the dosimetric accuracy of synthetic CT images generated from magnetic resonance imaging (MRI) data for focal brain radiation therapy, using a deep learning approach. Material and Methods: We conducted a study…

MR-only radiotherapy treatment planning requires accurate MR-to-CT synthesis. Current deep learning methods for MR-to-CT synthesis depend on pairwise aligned MR and CT training images of the same patient. However, misalignment between…

Computer Vision and Pattern Recognition · Computer Science 2017-08-04 Jelmer M. Wolterink , Anna M. Dinkla , Mark H. F. Savenije , Peter R. Seevinck , Cornelis A. T. van den Berg , Ivana Isgum

Purpose: CBCT-based adaptive radiotherapy requires daily images for accurate dose calculations. This study investigates the feasibility of applying a single convolutional network to facilitate CBCT-to-CT synthesis for head-and-neck, lung,…

A total of twenty paired CT and MR images were used in this study to investigate two conditional generative adversarial networks, Pix2Pix, and Cycle GAN, for generating synthetic CT images for Headand Neck cancer cases. Ten of the patient…

Computer Vision and Pattern Recognition · Computer Science 2019-02-28 Peter Klages , Ilyes Benslimane , Sadegh Riyahi , Jue Jiang , Margie Hunt , Joe Deasy , Harini Veeraraghavan , Neelam Tyagi

To achieve magnetic resonance (MR)-only radiotherapy, a method needs to be employed to estimate a synthetic CT (sCT) for generating electron density maps and patient positioning reference images. We investigated 2D and 3D convolutional…

Medical Physics · Physics 2019-08-06 Jie Fu , Yingli Yang , Kamal Singhrao , Dan Ruan , Daniel A. Low , John H. Lewis

Background: Synthetic computed tomography (sCT) has been proposed and increasingly clinically adopted to enable magnetic resonance imaging (MRI)-based radiotherapy. Deep learning (DL) has recently demonstrated the ability to generate…

Medical Physics · Physics 2023-07-25 Lotte Nijskens , Cornelis , AT van den Berg , Joost JC Verhoeff , Matteo Maspero

In many clinical settings, the use of both Computed Tomography (CT) and Magnetic Resonance (MRI) is necessary to pursue a thorough understanding of the patient's anatomy and to plan a suitable therapeutical strategy; this is often the case…

Image and Video Processing · Electrical Eng. & Systems 2024-07-16 Leonardo Crespi , Samuele Camnasio , Damiano Dei , Nicola Lambri , Pietro Mancosu , Marta Scorsetti , Daniele Loiacono

An MRI-only adaptive radiotherapy (ART) workflow is desirable for managing interfractional changes in anatomy, but producing synthetic CT (sCT) data through paired data-driven deep learning (DL) for abdominal dose calculations remains a…

Magnetic resonance (MR) and computer tomography (CT) imaging are valuable tools for diagnosing diseases and planning treatment. However, limitations such as radiation exposure and cost can restrict access to certain imaging modalities. To…

Image and Video Processing · Electrical Eng. & Systems 2023-06-08 Jiayuan Wang , Q. M. Jonathan Wu , Farhad Pourpanah

Image synthesis is used to generate synthetic CTs (sCTs) from on-treatment cone-beam CTs (CBCTs) with a view to improving image quality and enabling accurate dose computation to facilitate a CBCT-based adaptive radiotherapy workflow. As…

Image and Video Processing · Electrical Eng. & Systems 2023-12-05 Chelsea A. H. Sargeant , Edward G. A. Henderson , Dónal M. McSweeney , Aaron G. Rankin , Denis Page

In this work, a denoising Cycle-GAN (Cycle Consistent Generative Adversarial Network) is implemented to yield high-field, high resolution, high signal-to-noise ratio (SNR) Magnetic Resonance Imaging (MRI) images from simulated low-field,…

Image and Video Processing · Electrical Eng. & Systems 2023-07-14 Fernando Vega , Abdoljalil Addeh , M. Ethan MacDonald
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