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Double Reinforcement Learning (DRL) enables efficient inference for policy values in nonparametric Markov decision processes (MDPs), but existing methods face two major obstacles: (1) they require stringent intertemporal overlap conditions…

Machine Learning · Statistics 2025-11-14 Lars van der Laan , David Hubbard , Allen Tran , Nathan Kallus , Aurélien Bibaut

Reinforcement learning (RL) is a classical tool to solve network control or policy optimization problems in unknown environments. The original Q-learning suffers from performance and complexity challenges across very large networks. Herein,…

Machine Learning · Computer Science 2024-09-02 Talha Bozkus , Urbashi Mitra

Dynamic quantum circuits integrate unitary evolution with mid-circuit measurement and feedforward, enabling conditional operations essential for efficient quantum algorithms and foundational for fault-tolerant quantum computation. However,…

Quantum Physics · Physics 2026-04-22 Christopher Tong , Liran Shirizly , Edward H. Chen , Derek S. Wang , Bibek Pokharel

Sepsis is a leading cause of mortality and its treatment is very expensive. Sepsis treatment is also very challenging because there is no consensus on what interventions work best and different patients respond very differently to the same…

Machine Learning · Computer Science 2022-03-29 Pramod Kaushik , Sneha Kummetha , Perusha Moodley , Raju S. Bapi

Many real-world decision problems are characterized by multiple conflicting objectives which must be balanced based on their relative importance. In the dynamic weights setting the relative importance changes over time and specialized…

Machine Learning · Computer Science 2019-05-14 Axel Abels , Diederik M. Roijers , Tom Lenaerts , Ann Nowé , Denis Steckelmacher

In this paper, a novel robust tracking control scheme for a general class of discrete-time nonlinear systems affected by unknown bounded uncertainty is presented. By solving a parameterized optimal tracking control problem subject to the…

Systems and Control · Electrical Eng. & Systems 2023-12-08 Alexandros Tanzanakis , John Lygeros

Background: Inverse probability of treatment weighting (IPTW) is used for confounding adjustment in observational studies. Newer weighting methods include energy balancing (EB), kernel optimal matching (KOM), and tailored-loss covariate…

Methodology · Statistics 2026-01-15 Etienne Peyrot , Raphaël Porcher , Francois Petit

Q-learning has long been one of the most popular reinforcement learning algorithms, and theoretical analysis of Q-learning has been an active research topic for decades. Although researches on asymptotic convergence analysis of Q-learning…

Artificial Intelligence · Computer Science 2022-07-26 Han-Dong Lim , Donghwan Lee

Dynamic Treatment Regimes (DTRs) provide a systematic approach for making sequential treatment decisions that adapt to individual patient characteristics, particularly in clinical contexts where survival outcomes are of interest.…

Machine Learning · Computer Science 2025-03-11 Animesh Kumar Paul , Russell Greiner

It is well-known that information loss can occur in the classic and simple Q-learning algorithm. Entropy-based policy search methods were introduced to replace Q-learning and to design algorithms that are more robust against information…

Machine Learning · Computer Science 2020-06-29 Tung D. Nguyen , Kathryn E. Kasmarik , Hussein A. Abbass

Individualized treatment rules (ITRs) for treatment recommendation is an important topic for precision medicine as not all beneficial treatments work well for all individuals. Interpretability is a desirable property of ITRs, as it helps…

Methodology · Statistics 2023-11-06 Jacob M. Maronge , Jared D. Huling , Guanhua Chen

Observational data have been actively used to estimate treatment effect, driven by the growing availability of electronic health records (EHRs). However, EHRs typically consist of longitudinal records, often introducing time-dependent…

Machine Learning · Computer Science 2024-06-14 Junghwan Lee , Simin Ma , Nicoleta Serban , Shihao Yang

Q-learning is a stochastic approximation version of the classic value iteration. The literature has established that Q-learning suffers from both maximization bias and slower convergence. Recently, multi-step algorithms have shown practical…

Machine Learning · Computer Science 2024-07-03 Antony Vijesh , Shreyas S R

Recent works have shown that tackling offline reinforcement learning (RL) with a conditional policy produces promising results. The Decision Transformer (DT) combines the conditional policy approach and a transformer architecture, showing…

Machine Learning · Computer Science 2023-05-26 Taku Yamagata , Ahmed Khalil , Raul Santos-Rodriguez

Offline reinforcement learning is important in domains such as medicine, economics, and e-commerce where online experimentation is costly, dangerous or unethical, and where the true model is unknown. However, most methods assume all…

Machine Learning · Statistics 2025-10-30 David Bruns-Smith , Angela Zhou

Deep reinforcement learning techniques have demonstrated superior performance in a wide variety of environments. As improvements in training algorithms continue at a brisk pace, theoretical or empirical studies on understanding what these…

Machine Learning · Computer Science 2018-11-16 Raghuram Mandyam Annasamy , Katia Sycara

Analyzing the health status of patients based on Electronic Health Records (EHR) is a fundamental research problem in medical informatics. The presence of extensive missing values in EHR makes it challenging for deep neural networks (DNNs)…

Machine Learning · Computer Science 2025-03-14 Weibin Liao , Yinghao Zhu , Zhongji Zhang , Yuhang Wang , Zixiang Wang , Xu Chu , Yasha Wang , Liantao Ma

$Q$-learning is one of the most fundamental reinforcement learning (RL) algorithms. Despite its widespread success in various applications, it is prone to overestimation bias in the $Q$-learning update. To address this issue, double…

Machine Learning · Computer Science 2026-01-13 Hyunjun Na , Donghwan Lee

The optimal prophylaxis, and treatment if the prophylaxis fails, for a disease may be best evaluated using a sequential multiple assignment randomised trial (SMART). A SMART is a multi-stage study that randomises a participant to an initial…

Methodology · Statistics 2022-03-25 Robert K. Mahar , Katherine J. Lee , Bibhas Chakraborty , Agus Salim , Julie A. Simpson

Soft Q-learning is a variation of Q-learning designed to solve entropy regularized Markov decision problems where an agent aims to maximize the entropy regularized value function. Despite its empirical success, there have been limited…

Machine Learning · Computer Science 2024-09-06 Narim Jeong , Donghwan Lee