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Diagnosing medical conditions from histopathology data requires a thorough analysis across the various resolutions of Whole Slide Images (WSI). However, existing generative methods fail to consistently represent the hierarchical structure…

Image and Video Processing · Electrical Eng. & Systems 2024-07-19 Sarah Cechnicka , James Ball , Matthew Baugh , Hadrien Reynaud , Naomi Simmonds , Andrew P. T. Smith , Catherine Horsfield , Candice Roufosse , Bernhard Kainz

Digital pathology has advanced significantly over the last decade, with Whole Slide Images (WSIs) encompassing vast amounts of data essential for accurate disease diagnosis. High-resolution WSIs are essential for precise diagnosis but…

Image and Video Processing · Electrical Eng. & Systems 2024-08-28 Xuan Xu , Saarthak Kapse , Prateek Prasanna

We introduce the Pyramid Diffusion Model (PDM), a novel architecture designed for ultra-high-resolution image synthesis. PDM utilizes a pyramid latent representation, providing a broader design space that enables more flexible, structured,…

Computer Vision and Pattern Recognition · Computer Science 2024-03-20 Jiajie Yang

Ultra-high-resolution image generation poses great challenges, such as increased semantic planning complexity and detail synthesis difficulties, alongside substantial training resource demands. We present UltraPixel, a novel architecture…

Computer Vision and Pattern Recognition · Computer Science 2024-07-08 Jingjing Ren , Wenbo Li , Haoyu Chen , Renjing Pei , Bin Shao , Yong Guo , Long Peng , Fenglong Song , Lei Zhu

We show that cascaded diffusion models are capable of generating high fidelity images on the class-conditional ImageNet generation benchmark, without any assistance from auxiliary image classifiers to boost sample quality. A cascaded…

Computer Vision and Pattern Recognition · Computer Science 2021-12-20 Jonathan Ho , Chitwan Saharia , William Chan , David J. Fleet , Mohammad Norouzi , Tim Salimans

Medical image synthesis plays a crucial role in clinical workflows, addressing the common issue of missing imaging modalities due to factors such as extended scan times, scan corruption, artifacts, patient motion, and intolerance to…

Image and Video Processing · Electrical Eng. & Systems 2025-07-23 Xiaojiao Xiao , Qinmin Vivian Hu , Guanghui Wang

This work presents an extensive hyperparameter search on Image Diffusion Models for Echocardiogram generation. The objective is to establish foundational benchmarks and provide guidelines within the realm of ultrasound image and video…

Computer Vision and Pattern Recognition · Computer Science 2023-11-06 Hadrien Reynaud , Bernhard Kainz

Poor performance of quantitative analysis in histopathological Whole Slide Images (WSI) has been a significant obstacle in clinical practice. Annotating large-scale WSIs manually is a demanding and time-consuming task, unlikely to yield the…

Computer Vision and Pattern Recognition · Computer Science 2023-08-08 Sarah Cechnicka , James Ball , Hadrien Reynaud , Callum Arthurs , Candice Roufosse , Bernhard Kainz

Accurate diagnosis and treatment of complex diseases require integrating histological, molecular, and clinical data, yet in practice these modalities are often incomplete owing to tissue scarcity, assay cost, and workflow constraints.…

Computer Vision and Pattern Recognition · Computer Science 2026-04-07 Jinxi Xiang , Mingjie Li , Siyu Hou , Yijiang Chen , Xiangde Luo , Yuanfeng Ji , Xiang Zhou , Ehsan Adeli , Akshay Chaudhari , Curtis P. Langlotz , Kilian M. Pohl , Ruijiang Li

Image-to-image translation is a vital component in medical imaging processing, with many uses in a wide range of imaging modalities and clinical scenarios. Previous methods include Generative Adversarial Networks (GANs) and Diffusion Models…

Image and Video Processing · Electrical Eng. & Systems 2024-08-15 Yinchi Zhou , Tianqi Chen , Jun Hou , Huidong Xie , Nicha C. Dvornek , S. Kevin Zhou , David L. Wilson , James S. Duncan , Chi Liu , Bo Zhou

Unsupervised anomaly detection has gained significant attention in the field of medical imaging due to its capability of relieving the costly pixel-level annotation. To achieve this, modern approaches usually utilize generative models to…

Image and Video Processing · Electrical Eng. & Systems 2024-01-22 Rui Xu , Yunke Wang , Bo Du

Computed Tomography (CT) technology reduces radiation haz-ards to the human body through sparse sampling, but fewer sampling angles pose challenges for image reconstruction. Score-based generative models are widely used in sparse-view CT…

Image and Video Processing · Electrical Eng. & Systems 2025-12-22 Junyan Zhang , Mengxiao Geng , Pinhuang Tan , Yi Liu , Zhili Liu , Bin Huang , Qiegen Liu

We present a novel diffusion-based approach to generate synthetic histopathological Whole Slide Images (WSIs) at an unprecedented gigapixel scale. Synthetic WSIs have many potential applications: They can augment training datasets to…

Image and Video Processing · Electrical Eng. & Systems 2023-11-15 Robert Harb , Thomas Pock , Heimo Müller

Ultra-high-resolution image synthesis holds significant potential, yet remains an underexplored challenge due to the absence of standardized benchmarks and computational constraints. In this paper, we establish Aesthetic-4K, a meticulously…

Computer Vision and Pattern Recognition · Computer Science 2025-06-03 Jinjin Zhang , Qiuyu Huang , Junjie Liu , Xiefan Guo , Di Huang

Diffusion-based generative models have shown promise in synthesizing histopathology images to address data scarcity caused by privacy constraints. Diagnostic text reports provide high-level semantic descriptions, and masks offer…

Computer Vision and Pattern Recognition · Computer Science 2025-07-01 Mahesh Bhosale , Abdul Wasi , Yuanhao Zhai , Yunjie Tian , Samuel Border , Nan Xi , Pinaki Sarder , Junsong Yuan , David Doermann , Xuan Gong

Diffusion probabilistic models have recently achieved remarkable success in generating high-quality images. However, balancing high perceptual quality and low distortion remains challenging in application of diffusion models in image…

Image and Video Processing · Electrical Eng. & Systems 2025-12-23 Juan Song , Jiaxiang He , Lijie Yang , Mingtao Feng , Keyan Wang

Capsule endoscopy has enabled minimally invasive gastrointestinal imaging, but its clinical utility is limited by the inherently low resolution of captured images due to hardware, power, and transmission constraints. This limitation hampers…

Image and Video Processing · Electrical Eng. & Systems 2025-12-30 Haozhe Jia

Diffusion models have been increasingly used as strong generative priors for solving inverse problems such as super-resolution in medical imaging. However, these approaches typically utilize a diffusion prior trained at a single scale,…

Image and Video Processing · Electrical Eng. & Systems 2026-02-02 Darshan Thaker , Mahmoud Mostapha , Radu Miron , Shihan Qiu , Mariappan Nadar

Diffusion models have demonstrated significant potential in producing high-quality images in medical image translation to aid disease diagnosis, localization, and treatment. Nevertheless, current diffusion models have limited success in…

Image and Video Processing · Electrical Eng. & Systems 2024-11-26 Yunxiang Li , Hua-Chieh Shao , Xiaoxue Qian , You Zhang

Medical image synthesis has become an essential strategy for augmenting datasets and improving model generalization in data-scarce clinical settings. However, fine-grained and controllable synthesis remains difficult due to limited…

Image and Video Processing · Electrical Eng. & Systems 2025-09-09 Shuhan Ding , Jingjing Fu , Yu Gu , Naiteek Sangani , Mu Wei , Paul Vozila , Nan Liu , Jiang Bian , Hoifung Poon
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