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Late diagnosis and high costs are key factors that negatively impact the care of cancer patients worldwide. Although the availability of biological markers for the diagnosis of cancer type is increasing, costs and reliability of tests…

Machine Learning · Computer Science 2019-08-20 Sterling Ramroach , Melford John , Ajay Joshi

Semi-supervised learning has been employed to alleviate the need for extensive labeled data for histopathology image segmentation, but existing methods struggle with noisy pseudo-labels due to ambiguous gland boundaries and morphological…

Computer Vision and Pattern Recognition · Computer Science 2025-09-18 Nguyen Lan Vi Vu , Thanh-Huy Nguyen , Thien Nguyen , Daisuke Kihara , Tianyang Wang , Xingjian Li , Min Xu

Statistical inference on the cancer-site specificities of collective ultra-rare whole genome somatic mutations is an open problem. Traditional statistical methods cannot handle whole-genome mutation data due to their…

Methodology · Statistics 2023-01-02 Saptarshi Chakraborty , Zoe Guan , Colin B. Begg , Ronglai Shen

Survival analysis is a task to model the time until an event of interest occurs, widely used in clinical and biomedical research. A key challenge is to model patient heterogeneity while also adapting risk predictions to both individual…

Machine Learning · Computer Science 2025-10-31 Hyeonjun Lee , Hyungseob Shin , Gunhee Nam , Hyeonsoo Lee

For predicting cancer survival outcomes, standard approaches in clinical research are often based on two main modalities: pathology images for observing cell morphology features, and genomic (e.g., bulk RNA-seq) for quantifying gene…

Computer Vision and Pattern Recognition · Computer Science 2024-03-19 Hongxiao Wang , Yang Yang , Zhuo Zhao , Pengfei Gu , Nishchal Sapkota , Danny Z. Chen

Cancer diagnosis, prognosis, and therapeutic response predictions are based on morphological information from histology slides and molecular profiles from genomic data. However, most deep learning-based objective outcome prediction and…

Computer Vision and Pattern Recognition · Computer Science 2020-09-04 Richard J. Chen , Ming Y. Lu , Jingwen Wang , Drew F. K. Williamson , Scott J. Rodig , Neal I. Lindeman , Faisal Mahmood

Multi-omics data is increasingly being utilized to advance computational methods for cancer classification. However, multi-omics data integration poses significant challenges due to the high dimensionality, data complexity, and distinct…

Genomics · Quantitative Biology 2024-10-10 Fadi Alharbi , Aleksandar Vakanski , Boyu Zhang , Murtada K. Elbashir , Mohanad Mohammed

Multi-omic datasets offer opportunities for improved biomarker discovery in cancer research, but their high dimensionality and limited sample sizes make identifying compact and effective biomarker panels challenging. Feature selection in…

Genomics · Quantitative Biology 2026-04-02 Luca Cattelani , Vittorio Fortino

Cancer survival analysis commonly integrates information across diverse medical modalities to make survival-time predictions. Existing methods primarily focus on extracting different decoupled features of modalities and performing fusion…

Computer Vision and Pattern Recognition · Computer Science 2026-02-25 Huayi Wang , Haochao Ying , Yuyang Xu , Qibo Qiu , Cheng Zhang , Danny Z. Chen , Ying Sun , Jian Wu

Foundation models for medical image segmentation have achieved remarkable performance. Adaptive fine-tuning of natural image segmentation foundation models is crucial for medical image segmentation tasks. However, some limitations exist in…

Computer Vision and Pattern Recognition · Computer Science 2025-10-21 Xinwei Zhang , Hu Chen , Zhe Yuan , Sukun Tian , Peng Feng

The ability to customize a trained Deep Neural Network (DNN) locally using user-specific data may greatly enhance user experiences, reduce development costs, and protect user's privacy. In this work, we propose to incorporate a novel…

Computer Vision and Pattern Recognition · Computer Science 2018-11-02 Boyu Zhang , Azadeh Davoodi , Yu-Hen Hu

Cancer detection is one of the key research topics in the medical field. Accurate detection of different cancer types is valuable in providing better treatment facilities and risk minimization for patients. This paper deals with the…

Quantitative Methods · Quantitative Biology 2022-05-31 Yasamin Kowsari , Sanaz Nakhodchi , Davoud Gholamiangonabadi

Accurate cancer survival prediction requires integration of diverse data modalities that reflect the complex interplay between imaging, clinical parameters, and textual reports. However, existing multimodal approaches suffer from simplistic…

Machine Learning · Computer Science 2025-07-01 Aakash Tripathi , Asim Waqas , Matthew B. Schabath , Yasin Yilmaz , Ghulam Rasool

Mixture-of-Experts (MoE) models are designed to enhance the efficiency of large language models (LLMs) without proportionally increasing the computational demands. However, their deployment on edge devices still faces significant challenges…

Machine Learning · Computer Science 2024-08-21 Shuzhang Zhong , Ling Liang , Yuan Wang , Runsheng Wang , Ru Huang , Meng Li

Originally introduced as a neural network for ensemble learning, mixture of experts (MoE) has recently become a fundamental building block of highly successful modern deep neural networks for heterogeneous data analysis in several…

Machine Learning · Statistics 2024-02-12 Huy Nguyen , TrungTin Nguyen , Khai Nguyen , Nhat Ho

Mixture-of-Experts (MoE) is a promising way to scale up the learning capacity of large language models. It increases the number of parameters while keeping FLOPs nearly constant during inference through sparse activation. Yet, it still…

Machine Learning · Computer Science 2025-02-26 Pingzhi Li , Xiaolong Jin , Zhen Tan , Yu Cheng , Tianlong Chen

Clustering high-dimensional data, such as images or biological measurements, is a long-standingproblem and has been studied extensively. Recently, Deep Clustering has gained popularity due toits flexibility in fitting the specific…

Machine Learning · Computer Science 2020-12-21 Andreas Kopf , Vincent Fortuin , Vignesh Ram Somnath , Manfred Claassen

Mixture-of-experts (MoE) is becoming popular due to its success in improving the model quality, especially in Transformers. By routing tokens with a sparse gate to a few experts (i.e., a small pieces of the full model), MoE can easily…

Machine Learning · Computer Science 2022-10-11 Xiaonan Nie , Xupeng Miao , Shijie Cao , Lingxiao Ma , Qibin Liu , Jilong Xue , Youshan Miao , Yi Liu , Zhi Yang , Bin Cui

Larger networks generally have greater representational power at the cost of increased computational complexity. Sparsifying such networks has been an active area of research but has been generally limited to static regularization or…

Computer Vision and Pattern Recognition · Computer Science 2019-04-15 Xin Wang , Fisher Yu , Lisa Dunlap , Yi-An Ma , Ruth Wang , Azalia Mirhoseini , Trevor Darrell , Joseph E. Gonzalez

The computational cost associated with high-fidelity CFD simulations remains a significant bottleneck in the automotive design and optimization cycle. While ML-based surrogate models have emerged as a promising alternative to accelerate…

Machine Learning · Computer Science 2025-09-01 Mohammad Amin Nabian , Sanjay Choudhry