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We discuss a novel use of the Geant4 simulation toolkit to model molecular transport in a vacuum environment, in the molecular flow regime. The Geant4 toolkit was originally developed by the high energy physics community to simulate the…

Computational Physics · Physics 2013-10-07 J. Singal , J. Langton , R. Schindler

Backscattering is a sensitive probe of the accuracy of electron scattering algorithms implemented in Monte Carlo codes. The capability of the Geant4 toolkit to describe realistically the fraction of electrons backscattered from a target…

The integrated positron emission tomography/magnetic resonance imaging (PET/MRI) scanner facilitates the simultaneous acquisition of metabolic information via PET and morphological information with high soft-tissue contrast using MRI.…

Computer Vision and Pattern Recognition · Computer Science 2024-10-30 Hidetoshi Matsuo , Mizuho Nishio , Munenobu Nogami , Feibi Zeng , Takako Kurimoto , Sandeep Kaushik , Florian Wiesinger , Atsushi K Kono , Takamichi Murakami

Positron Emission Tomography (PET) is an essential technique in many clinical applications that allows for quantitative imaging at the molecular level. This study aims to develop a denoising method using novel dilated convolutional neural…

Medical Physics · Physics 2021-01-27 Karl Spuhler , Mario Serrano-Sosa , Renee Cattell , Christine DeLorenzo , Chuan Huang

The rapid development of X-ray astronomy has been made possible by widely deploying X-ray focusing telescopes on board many X-ray satellites. Geant4 is a very powerful toolkit for Monte Carlo simulations and has remarkable abilities to…

Instrumentation and Methods for Astrophysics · Physics 2017-03-29 Donghua Zhao , Chen Zhang , Weimin Yuan , Shuangnan Zhang , Richard Willingale , Zhixing Ling

Geant4 is an object-oriented toolkit for the simulation of the passage of particles through matter. Its development was initially motivated by the requirements of physics experiments at high energy hadron colliders under construction in the…

Gas Electron Multiplier (GEM)-based detectors using a layer of 10B as a neutron converter is becoming popular for thermal neutron detection. A common strategy to simulate this kind of detector is based on two frameworks: Geant4 and…

Instrumentation and Detectors · Physics 2022-12-21 R. Felix dos Santos , M. G. Munhoz , M. Moralles , L. A. Serra Filho , M. Bregant , F. A. Souza

This work aims at applying the theory of the component-based normalization for the Jagiellonian PET scanner, currently under development at the Jagiellonian University. In any Positron Emission Tomography acquisition, efficiency along a…

Medical Physics · Physics 2024-09-04 Aurélien Coussat , Wojciech Krzemien , Jakub Baran , Szymon Parzych

Dynamic total body positron emission tomography (TB-PET) makes it feasible to measure the kinetics of all organs in the body simultaneously which may lead to important applications in multi-organ disease and systems physiology. Since…

Medical Physics · Physics 2026-01-14 Yun Zhao , Qinlin Gu , Georgios I. Angelis , Andrew J. Reader , Yanan Fan , Steven R. Meikle

The novel whole-body PET system based on plastic scintillators is developed by the {J-PET} Collaboration. It consists of plastic scintillator strips arranged axially in the form of a cylinder, allowing the cost-effective construction of the…

Positron Emission Tomography (PET) imaging requires accurate attenuation correction (AC) to account for photon loss due to tissue density variations. In PET/MR systems, computed tomography (CT), which offers a straightforward estimation of…

Image and Video Processing · Electrical Eng. & Systems 2025-04-11 Weijie Chen , James Wang , Alan McMillan

Positron Emission Tomography (PET) enables functional imaging of deep brain structures, but the bulk and weight of current systems preclude their use during many natural human activities, such as locomotion. The proposed long-term solution…

Robotics · Computer Science 2023-12-01 Junxiang Wang , Ti Wu , Iulian I. Iordachita , Peter Kazanzides

Previously reported nanodosimetric measurements of therapeutic-energy carbon ions penetrating simulated tissue have produced results that are incompatible with the predicted mean energy of the carbon ions in the nanodosimeter and previous…

Medical Physics · Physics 2025-10-27 Miriam Schwarze , Gerhard Hilgers , Hans Rabus

Dynamic positron emission tomography (PET) with [$^{18}$F]FDG enables non-invasive quantification of glucose metabolism through kinetic analysis, often modelled by the two-tissue compartment model (TCKM). However, voxel-wise kinetic…

Image and Video Processing · Electrical Eng. & Systems 2025-04-25 Kartikay Tehlan , Thomas Wendler

In this study, the absorbed dose calculation for the cerebral region is refined using the Geant4 software, along with the ROOT and GATE programs. This approach provides a detailed statistical analysis of positron trajectories within a water…

Medical Physics · Physics 2025-05-06 Walter Sabalza-Castillejo , Miguel Martin-Landrove

In this article, we introduce, a novel open-source framework designed for efficient parallel computation of projections in tomography leveraging either multiple CPU cores or GPUs. This framework efficiently implements forward and back…

Medical Physics · Physics 2023-12-18 Georg Schramm , Kris Thielemans

Total-body PET/CT enables system-wide molecular imaging, but heterogeneous anatomical and metabolic signals, approximately 2 m axial coverage, and structured radiology semantics challenge existing medical AI models that assume…

Computer Vision and Pattern Recognition · Computer Science 2026-01-21 Wei Chen , Liang Wu , Shuyi Lu , Yuanyuan Sun , Wenkai Bi , Zilong Yuan , Yaoyao He , Feng Wang , Junchi Ma , Shuyong Liu , Zhaoping Cheng , Xiaoyan Hu , Jianfeng Qiu

For the last three years, the AutoPET competition gathered the medical imaging community around a hot topic: lesion segmentation on Positron Emitting Tomography (PET) scans. Each year a different aspect of the problem is presented; in 2024…

Image and Video Processing · Electrical Eng. & Systems 2025-09-05 Zacharia Mesbah , Léo Mottay , Romain Modzelewski , Pierre Decazes , Sébastien Hapdey , Su Ruan , Sébastien Thureau

Precise quantitative delineation of tumor hypoxia is essential in radiation therapy treatment planning to improve the treatment efficacy by targeting hypoxic sub-volumes. We developed a combined imaging system of positron emission…

A comprehensive analysis of the effects of Geant4 algorithms for condensed transport in detectors is in progress. The first phase of the project focuses on electron multiple scattering, and studies two related observables: the longitudinal…

Computational Physics · Physics 2015-06-11 M. Batic , G. Hoff , M. G. Pia