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We present a setup for complete characterization of femtosecond pulses generated by seeded free-electron lasers (FEL's) in the extreme-ultraviolet spectral region. Two delayed and spectrally shifted replicas are produced and used for…

Single Particle Imaging techniques at X-ray lasers have made significant strides, yet the challenge of determining the orientation of freely rotating molecules during delivery remains. In this study, we propose a novel method to partially…

Chemical Physics · Physics 2025-10-27 Tomas André , Emiliano De Santis , Nicusor Timneanu , Carl Caleman

Fourier single-pixel imaging (FSI) is a branch of single-pixel imaging techniques. It uses Fourier basis patterns as structured patterns for spatial information acquisition in the Fourier domain. However, the spatial resolution of the image…

Image and Video Processing · Electrical Eng. & Systems 2021-08-06 Ziheng Qiu , Xinyi Guo , Tianao Lu , Pan Qi , Zibang Zhang , Jingang Zhong

Reconstructing high-quality images from substantially undersampled k-space data for accelerated MRI presents a challenging ill-posed inverse problem. While supervised deep learning has revolutionized this field, it relies heavily on large…

Image and Video Processing · Electrical Eng. & Systems 2025-12-22 Xinzhe Luo , Yingzhen Li , Chen Qin

Micromagnetic tomography aims at reconstructing large numbers of individual magnetizations of magnetic particles from combining high-resolution magnetic scanning techniques with micro X-ray computed tomography (microCT). Previous work…

Geophysics · Physics 2021-05-05 David Cortés-Ortuño , Karl Fabian , Lennart V. de Groot

We study the local distortion of the atomic structure in small biological samples illuminated by x-ray free electron laser (XFEL) pulses. We concentrate on the effect of inhomogenities: heavy atoms in a light matrix and non-homogeneous…

Atomic and Molecular Clusters · Physics 2015-05-13 Zoltan Jurek , Gyula Faigel

Understanding the structure of supramolecular complexes provides insight into their functional capabilities and how they can be modulated in the context of disease. Super-resolution microscopy (SRM) excels in performing this task by…

Quantitative Methods · Quantitative Biology 2023-08-09 Afonso Mendes , Hannah S. Heil , Simao Coelho , Christophe Leterrier , Ricardo Henriques

Motivation: Structural heterogeneity in single-particle cryo-electron microscopy (cryo-EM) data represents a major challenge for high-resolution structure determination. Unsupervised classification may serve as the first step in the…

Data Analysis, Statistics and Probability · Physics 2017-11-01 Jiayi Wu , Yong-Bei Ma , Charles Congdon , Bevin Brett , Shuobing Chen , Qi Ouyang , Youdong Mao

Magnetic Resonance Imaging (MRI) produces excellent soft tissue contrast, albeit it is an inherently slow imaging modality. Promising deep learning methods have recently been proposed to reconstruct accelerated MRI scans. However, existing…

Image and Video Processing · Electrical Eng. & Systems 2024-04-17 Yilmaz Korkmaz , Tolga Cukur , Vishal M. Patel

Structure determination is a key application of XFELs and 4th generation synchrotron sources, particularly using the coherent and pulsed X-ray radiation from X-ray free-electron lasers (XFEL). Scientific interest focuses on understanding…

Instrumentation and Detectors · Physics 2025-03-07 Markus Kuster , Robert Hartmann , Steffen Hauf , Peter Holl , Tonn Rüter , Lothar Strüder

Confocal laser scanning microscopy (CLSM) stands out as one of the most widely used microscopy techniques, thanks to its three-dimensional imaging capability and its sub-diffraction spatial resolution, achieved through the closure of a…

The speed and quality of single-pixel imaging (SPI) are fundamentally limited by image modulation frequency and by the levels of optical noise and compression noise. In an approach to come close to these limits, we introduce a SPI…

Optics · Physics 2022-05-25 Anna Pastuszczak , Rafał Stojek , Piotr Wróbel , Rafał Kotyński

Solving the challenging problem of 3D object reconstruction from a single image appropriately gives existing technologies the ability to perform with a single monocular camera rather than requiring depth sensors. In recent years, thanks to…

Computer Vision and Pattern Recognition · Computer Science 2021-08-18 Guiju Ping , Mahdi Abolfazli Esfahani , Han Wang

In 3D single particle imaging with X-ray free-electron lasers, particle orientation is not recorded during measurement but is instead recovered as a necessary step in the reconstruction of a 3D image from the diffraction data. Here we use…

Data Analysis, Statistics and Probability · Physics 2016-05-25 Julien Flamant , Nicolas Le Bihan , Andrew V. Martin , Jonathan H. Manton

This paper presents an innovative approach to computational acoustic imaging of biperiodic surfaces, exploiting the capabilities of an acoustic superlens to overcome the diffraction limit. We address the challenge of imaging physical…

Analysis of PDEs · Mathematics 2026-01-05 Yuliang Wang

The in situ synchrotron high-energy X-ray powder diffraction (XRD) technique is highly utilized by researchers to analyze the crystallographic structures of materials in functional devices (e.g., battery materials) or in complex sample…

Image and Video Processing · Electrical Eng. & Systems 2022-12-16 Howard Yanxon , James Weng , Hannah Parraga , Wenqian Xu , Uta Ruett , Nicholas Schwarz

Single-pixel imaging can collect images at the wavelengths outside the reach of conventional focal plane array detectors. However, the limited image quality and lengthy computational times for iterative reconstruction still impede the…

Image and Video Processing · Electrical Eng. & Systems 2023-11-20 Kai Song , Yaoxing Bian , Ku Wu , Hongrui Liu , Shuangping Han , Jiaming Li , Jiazhao Tian , Chengbin Qin , Jianyong Hu , Liantuan Xiao

Limited-angle X-ray tomography reconstruction is an ill-conditioned inverse problem in general. Especially when the projection angles are limited and the measurements are taken in a photon-limited condition, reconstructions from classical…

Image and Video Processing · Electrical Eng. & Systems 2021-12-21 Zhen Guo , Jung Ki Song , George Barbastathis , Michael E. Glinsky , Courtenay T. Vaughan , Kurt W. Larson , Bradley K. Alpert , Zachary H. Levine

Single-particle cryo-electron microscopy (cryo-EM) reconstructs the three-dimensional (3D) structure of bio-molecules from a large set of 2D projection images with random and unknown orientations. A crucial step in the single-particle…

Image and Video Processing · Electrical Eng. & Systems 2020-06-24 Mona Zehni , Laurène Donati , Emmanuel Soubies , Zhizhen J. Zhao , Michael Unser

The ability to directly follow and time resolve the rearrangement of the nuclei within molecules is a frontier of science that requires atomic spatial and few-femtosecond temporal resolutions. While laser induced electron diffraction can…