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We propose algorithms based on an optimisation method for inverse multislice ptychography in, e.g. electron microscopy. The multislice method is widely used to model the interaction between relativistic electrons and thick specimens. Since…

Electron ptychography describes a family of algorithms which are used to enable the reconstruction of complex specimen transmission functions of a sample in order to obtain both phase and amplitude information, as applied within the realms…

Optics · Physics 2025-03-17 L. Clark , P. D. Nellist

A detailed analysis of ptychography for 3D phase reconstructions of thick specimens is performed. We introduce multi-focus ptychography, which incorporates a 4D-STEM defocus series to enhance the quality of 3D reconstructions along the beam…

Size effects are ubiquitous in the structural, mechanical, and physical properties of materials, making it highly desirable to study the intrinsic properties of thick objects through high-resolution structural analysis in transmission…

Materials Science · Physics 2025-02-26 Wenfeng Yang , Haozhi Sha , Jizhe Cui , Rong Yu

In photon upconverting core-shell nanoparticles, structure strongly dictates performance. Conventional imaging in scanning transmission electron microscopy has sufficient resolution to probe the atomic structure of these nanoparticles, but…

Ptychography is a well-studied phase imaging method that makes non-invasive imaging possible at a nanometer scale. It has developed into a mainstream technique with various applications across a range of areas such as material science or…

Image and Video Processing · Electrical Eng. & Systems 2022-08-01 Semih Barutcu , Aggelos K. Katsaggelos , Doğa Gürsoy

Three-dimensional atomic resolution imaging using transmission electron microscopes is a unique capability that requires challenging experiments. Linear electron tomography methods are limited by the missing wedge effect, requiring a high…

Computational Physics · Physics 2024-07-30 Shengboy You , Andrey Romanov , Philipp Pelz

Ptychography is a data-intensive computational imaging technique that achieves high spatial resolution over large fields of view. The technique involves scanning a coherent beam across overlapping regions and recording diffraction patterns.…

Image and Video Processing · Electrical Eng. & Systems 2025-05-14 Refik Mert Cam , Junjing Deng , Rajkumar Kettimuthu , Mathew J. Cherukara , Tekin Bicer

Multislice electron ptychography (MEP) is an inverse imaging technique that computationally reconstructs the highest-resolution images of atomic crystal structures from diffraction patterns. Available algorithms often solve this inverse…

Image and Video Processing · Electrical Eng. & Systems 2025-07-28 Christian K. Belardi , Chia-Hao Lee , Yingheng Wang , Justin Lovelace , Kilian Q. Weinberger , David A. Muller , Carla P. Gomes

Realistic microscale domains are an essential step towards making modern multiscale simulations more applicable to computational materials engineering. For this purpose, 3D computed tomography scans can be very expensive or technically…

Ptychography is an emerging imaging technique that is able to provide wavelength-limited spatial resolution from specimen with extended lateral dimensions. As a scanning microscopy method, a typical two-dimensional image requires a number…

Electron microscopy has shown to be a very powerful tool to map the chemical nature of samples at various scales down to atomic resolution. However, many samples can not be analyzed with an acceptable signal-to-noise ratio because of the…

Image and Video Processing · Electrical Eng. & Systems 2018-02-28 Étienne Monier , Thomas Oberlin , Nathalie Brun , Marcel Tencé , Marta de Frutos , Nicolas Dobigeon

Highly multiplexed microscopy enables rich spatial characterization of tissues at single-cell resolution, yet most analyses rely on two-dimensional sections despite inherently three-dimensional tissue organization. Acquiring dense…

Computer Vision and Pattern Recognition · Computer Science 2026-04-10 Ido Harlev , Tamar Oukhanov , Raz Ben-Uri , Leeat Keren , Shai Bagon

Micromechanical constitutive parameters are important for many engineering materials, typically in microelectronic applications and material design. Their accurate identification poses a three-fold experimental challenge: (i) deformation of…

Soft Condensed Matter · Physics 2023-02-08 O. Rokoš , R. H. J. Peerlings , J. P. M. Hoefnagels , M. G. D. Geers

Ptychographic reconstructions in reflection geometries are commonly interpreted with the same two-dimensional thin-sample model used in transmission, yet the validity of this approximation has not been established. We develop a…

Optics · Physics 2026-04-08 Sander Senhorst , Stefan Witte , Wim Coene

While three-dimensional imaging is essential for clinical diagnosis, its high cost and long wait times have motivated the use of image-to-3D foundation models to infer volume from two-dimensional modalities. However, because these models…

Computer Vision and Pattern Recognition · Computer Science 2026-03-03 Yan Luo , Advaith Ravishankar , Serena Liu , Yutong Yang , Mengyu Wang

Ptychography is a scanning coherent diffractive imaging technique that enables imaging nanometer-scale features in extended samples. One main challenge is that widely used iterative image reconstruction methods often require significant…

Image and Video Processing · Electrical Eng. & Systems 2024-12-17 Canberk Ekmekci , Tekin Bicer , Zichao Wendy Di , Junjing Deng , Mujdat Cetin

Electron tomography offers important three-dimensional (3D) structural information which cannot be observed by two-dimensional imaging. By combining annular dark field scanning transmission electron microscopy (ADF-STEM) with aberration…

Materials Science · Physics 2023-06-29 Juhyeok Lee , Moosung Lee , YongKeun Park , Colin Ophus , Yongsoo Yang

A method of modelling the three-dimensional microstructure of random isotropic two-phase materials is proposed. The information required to implement the technique can be obtained from two-dimensional images of the microstructure. The…

Disordered Systems and Neural Networks · Physics 2009-10-31 Anthony Roberts

Atomic-resolution imaging with scanning transmission electron microscopy is a powerful tool for characterizing the nanoscale structure of materials, in particular features such as defects, local strains, and symmetry-breaking distortions.…

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