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Many successful methods developed for medical image analysis that are based on machine learning use supervised learning approaches, which often require large datasets annotated by experts to achieve high accuracy. However, medical data…

The promise of self-supervised learning (SSL) is to leverage large amounts of unlabeled data to solve complex tasks. While there has been excellent progress with simple, image-level learning, recent methods have shown the advantage of…

We present a novel approach to unsupervised learning for video object segmentation (VOS). Unlike previous work, our formulation allows to learn dense feature representations directly in a fully convolutional regime. We rely on uniform grid…

While supervised object detection methods achieve impressive accuracy, they generalize poorly to images whose appearance significantly differs from the data they have been trained on. To address this in scenarios where annotating data is…

Many eye diseases like Diabetic Macular Edema (DME), Age-related Macular Degeneration (AMD), and Glaucoma manifest in the retina, can cause irreversible blindness or severely impair the central version. The Optical Coherence Tomography…

Speckle noise and retinal shadows within OCT B-scans occlude important edges, fine textures and deep tissues, preventing accurate and robust diagnosis by algorithms and clinicians. We developed a single process that successfully removed…

Deep learning (DL) has shown promise for faster, high quality accelerated MRI reconstruction. However, supervised DL methods depend on extensive amounts of fully-sampled (labeled) data and are sensitive to out-of-distribution (OOD) shifts,…

Spatial resolution in optical microscopy has traditionally been treated as a fixed parameter of the optical system. Here, we present an approach to enhance transverse resolution in beam-scanned optical coherence tomography (OCT) beyond its…

This letter introduces a physics-informed self-supervised framework for sonar image despeckling that reformulates despeckling as residual consistency in the homomorphic log domain. By constraining the log-ratio residual to obey…

Segmentation of retinal layers from Optical Coherence Tomography (OCT) volumes is a fundamental problem for any computer aided diagnostic algorithm development. This requires preprocessing steps such as denoising, region of interest…

Deep learning (DL) has arguably emerged as the method of choice for the detection and segmentation of biological structures in microscopy images. However, DL typically needs copious amounts of annotated training data that is for biomedical…

Holographic optical coherence tomography (OCT) is a powerful imaging technique, but its ability to reveal low-reflectivity features is limited. In this study, we performed holographic OCT by incoherently averaging volumes with changing…

Single-pixel imaging (SPI) is a novel, unconventional method that goes beyond the notion of traditional cameras but can be computationally expensive and slow for real-time applications. Deep learning has been proposed as an alternative…

In ultrasound imaging the appearance of homogeneous regions of tissue is subject to speckle, which for certain applications can make the detection of tissue irregularities difficult. To cope with this, it is common practice to apply speckle…

Optical coherence tomography angiography (OCTA) is a novel non-invasive imaging modality for the visualisation of microvasculature in vivo that has encountered broad adoption in retinal research. OCTA potential in the assessment of…

Super-resolution and denoising are ill-posed yet fundamental image restoration tasks. In blind settings, the degradation kernel or the noise level are unknown. This makes restoration even more challenging, notably for learning-based…

Serial sectioning Optical Coherence Tomography (sOCT) is a high-throughput, label free microscopic imaging technique that is becoming increasingly popular to study post-mortem neurovasculature. Quantitative analysis of the vasculature…

Purpose: To develop a deep learning approach to digitally-stain optical coherence tomography (OCT) images of the optic nerve head (ONH). Methods: A horizontal B-scan was acquired through the center of the ONH using OCT (Spectralis) for 1…

Contrast and quality of ultrasound images are adversely affected by the excessive presence of speckle. However, being an inherent imaging property, speckle helps in tissue characterization and tracking. Thus, despeckling of the ultrasound…

Convolutional Neural Network models have successfully detected retinal illness from optical coherence tomography (OCT) and fundus images. These CNN models frequently rely on vast amounts of labeled data for training, difficult to obtain,…