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Accurate bone strength prediction is essential for assessing fracture risk, particularly in aging populations and individuals with osteoporosis. Bone imaging has evolved from X-rays and DXA to clinical computed tomography (CT), and now to…

Quantitative Methods · Quantitative Biology 2025-12-04 John Rick Manzanares , Richard Leslie Abel , Paweł Dłotko

We present the application of topological data analysis (TDA) to study unweighted complex networks via their persistent homology. By endowing appropriate weights that capture the inherent topological characteristics of such a network, we…

Discrete Mathematics · Computer Science 2021-02-03 Indrava Roy , Sudharsan Vijayaraghavan , Sarath Jyotsna Ramaia , Areejit Samal

Surface roughness plays an important role in analyzing engineering surfaces. It quantifies the surface topography and can be used to determine whether the resulting surface finish is acceptable or not. Nevertheless, while several existing…

Signal Processing · Electrical Eng. & Systems 2021-10-20 Melih C. Yesilli , Firas A. Khasawneh

Topological Data Analysis (TDA) can be used to detect and characterize holes in an image, such as zero-dimensional holes (connected components) or one-dimensional holes (loops). However, there is currently no widely accepted statistical…

Methodology · Statistics 2025-08-26 Susan Glenn , Jessi Cisewski-Kehe , Jun Zhu , William M Bement

Topological Data Analysis (TDA) is an approach to handle with big data by studying its shape. A main tool of TDA is the persistence diagram, and one can use it to compare data sets. One approach to learn on the similarity between two…

Applications · Statistics 2020-03-04 Sarit Agami

In this article, we introduce a Topological Data Analysis (TDA) pipeline for neural spike train data. Understanding how the brain transforms sensory information into perception and behavior requires analyzing coordinated neural population…

Methodology · Statistics 2025-12-10 Cagatay Ayhan , Audrey N. Nash , Roberto Vincis , Martin Bauer , Richard Bertram , Tom Needham

Identifying molecular signatures from complex disease patients with underlying symptomatic similarities is a significant challenge in the analysis of high dimensional multi-omics data. Topological data analysis (TDA) provides a way of…

Genomics · Quantitative Biology 2024-04-23 Davide Gurnari , Aldo Guzmán-Sáenz , Filippo Utro , Aritra Bose , Saugata Basu , Laxmi Parida

Exploring the shape of point configurations has been a key driver in the evolution of TDA (short for topological data analysis) since its infancy. This survey illustrates the recent efforts to broaden these ideas to model spatial…

Computational Geometry · Computer Science 2024-06-07 Sebastiano Cultrera di Montesano , Ondrej Draganov , Herbert Edelsbrunner , Morteza Saghafian

Topological Data Analysis has grown in popularity in recent years as a way to apply tools from algebraic topology to large data sets. One of the main tools in topological data analysis is persistent homology. This paper uses undergraduate…

Algebraic Topology · Mathematics 2024-06-26 Cheyne Glass , Elizabeth Vidaurre

Despite significant advances in the field of deep learning in ap-plications to various areas, an explanation of the learning pro-cess of neural network models remains an important open ques-tion. The purpose of this paper is a comprehensive…

Machine Learning · Computer Science 2023-06-07 German Magai

The effectiveness of Spatio-temporal Graph Neural Networks (STGNNs) in time-series applications is often limited by their dependence on fixed, hand-crafted input graph structures. Motivated by insights from the Topological Data Analysis…

Machine Learning · Computer Science 2025-03-20 Viet The Nguyen , Duy Anh Pham , An Thai Le , Jans Peter , Gunther Gust

Dimensionality reduction is a crucial step for pattern recognition and data mining tasks to overcome the curse of dimensionality. Principal component analysis (PCA) is a traditional technique for unsupervised dimensionality reduction, which…

Machine Learning · Computer Science 2017-05-04 Zan Gao , Guotai Zhang , Feiping Nie , Hua Zhang

In recent years, semi-supervised graph learning with data augmentation (DA) is currently the most commonly used and best-performing method to enhance model robustness in sparse scenarios with few labeled samples. Differing from homogeneous…

Machine Learning · Computer Science 2022-12-02 Ying Chen , Siwei Qiang , Mingming Ha , Xiaolei Liu , Shaoshuai Li , Lingfeng Yuan , Xiaobo Guo , Zhenfeng Zhu

Topological data analysis (TDA) approaches are becoming increasingly popular for studying the dependence patterns in multivariate time series data. In particular, various dependence patterns in brain networks may be linked to specific tasks…

Methodology · Statistics 2023-12-04 Anass B. El-Yaagoubi , Hernando Ombao

By their nature it is difficult to differentiate chaotic dynamical systems through measurement. In recent years, work has begun on using methods of Topological Data Analysis (TDA) to qualitatively type dynamical data by approximating the…

Algebraic Topology · Mathematics 2026-04-14 Tobias Timofeyev , Christopher Potvin , Benjamin Jones , Kristin M. Kurianski , Miguel Lopez , Sunia Tanweer

Topological data analysis (TDA) studies the shape patterns of data. Persistent homology is a widely used method in TDA that summarizes homological features of data at multiple scales and stores them in persistence diagrams (PDs). In this…

Machine Learning · Statistics 2022-09-16 Theodore Papamarkou , Farzana Nasrin , Austin Lawson , Na Gong , Orlando Rios , Vasileios Maroulas

Long, flexible physical filaments are naturally tangled and knotted, from macroscopic string down to long-chain molecules. The existence of knotting in a filament naturally affects its configuration and properties, and may be very stable or…

Biomolecules · Quantitative Biology 2016-11-21 Keith Alexander , Alexander J Taylor , Mark R Dennis

We study the complexity of a classic problem in computational topology, the homology problem: given a description of some space $X$ and an integer $k$, decide if $X$ contains a $k$-dimensional hole. The setting and statement of the homology…

Quantum Physics · Physics 2024-10-08 Robbie King , Tamara Kohler

Understanding the behavior and evolution of a dynamical many-body system by analyzing patterns in their experimentally captured images is a promising method relevant for a variety of living and non-living self-assembled systems. The arrays…

A time-delay embedding (TDE), grounded in the framework of Takens's Theorem, provides a mechanism to represent and analyze the inherent dynamics of time-series data. Recently, topological data analysis (TDA) methods have been applied to…

Methodology · Statistics 2024-10-18 Sixtus Dakurah , Jessi Cisewski-Kehe
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