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We pretrain METAGENE-1, a 7-billion-parameter autoregressive transformer model, which we refer to as a metagenomic foundation model, on a novel corpus of diverse metagenomic DNA and RNA sequences comprising over 1.5 trillion base pairs.…

Genomics · Quantitative Biology 2025-01-07 Ollie Liu , Sami Jaghouar , Johannes Hagemann , Shangshang Wang , Jason Wiemels , Jeff Kaufman , Willie Neiswanger

Metadynamics is a powerful method to accelerate molecular dynamics simulations, but its efficiency critically depends on the identification of collective variables that capture the slow modes of the process. Unfortunately, collective…

Chemical Physics · Physics 2023-07-17 Ofir Blumer , Shlomi Reuveni , Barak Hirshberg

Meta-learning has been proposed as a framework to address the challenging few-shot learning setting. The key idea is to leverage a large number of similar few-shot tasks in order to learn how to adapt a base-learner to a new task for which…

Computer Vision and Pattern Recognition · Computer Science 2019-10-10 Qianru Sun , Yaoyao Liu , Zhaozheng Chen , Tat-Seng Chua , Bernt Schiele

Emerging technologies present opportunities for system designers to meet the challenges presented by competing trends of big data analytics and limitations on CMOS scaling. Specifically, memristors are an emerging high-density technology…

Emerging Technologies · Computer Science 2016-01-21 Yang Liu , Chris Dwyer , Alvin R. Lebeck

The storage stack in the traditional operating system is primarily optimized towards improving the CPU utilization and hiding the long I/O latency imposed by the slow I/O devices such as hard disk drivers (HDDs). However, the emerging…

Operating Systems · Computer Science 2023-06-21 Junzhe Li , Xiurui Pan , Shushu Yi , Jie Zhang

Large organizations today are being served by different types of data processing and informations systems, ranging from the operational (OLTP) systems, data warehouse systems, to data mining and business intelligence applications. It is…

Databases · Computer Science 2007-05-23 N. L. Sarda

This paper addresses the problem of efficiently storing and accessing massive data blocks in a large-scale distributed environment, while providing efficient fine-grain access to data subsets. This issue is crucial in the context of…

Distributed, Parallel, and Cluster Computing · Computer Science 2008-10-14 Bogdan Nicolae , Gabriel Antoniu , Luc Bougé

Data scarcity poses a serious threat to modern machine learning and artificial intelligence, as their practical success typically relies on the availability of big datasets. One effective strategy to mitigate the issue of insufficient data…

Machine Learning · Computer Science 2026-05-14 Chaozhi Zhang , Lin Liu , Xiaoqun Zhang

We present a novel architecture for sparse pattern processing, using flash storage with embedded accelerators. Sparse pattern processing on large data sets is the essence of applications such as document search, natural language processing,…

Hardware Architecture · Computer Science 2017-01-25 Sang-Woo Jun , Huy T. Nguyen , Vijay N. Gadepally , Arvind

Deep learning (DL) techniques have shown unprecedented success when applied to images, waveforms, and text. Generally, when the sample size ($N$) is much bigger than the number of features ($d$), DL often outperforms other machine learning…

Computer Vision and Pattern Recognition · Computer Science 2018-06-26 Thanh Hai Nguyen , Edi Prifti , Yann Chevaleyre , Nataliya Sokolovska , Jean-Daniel Zucker

Genomic and metagenomic fields, generating huge sets of short genomic sequences, brought their own share of high performance problems. To extract relevant pieces of information from the huge data sets generated by current sequencing…

Data Structures and Algorithms · Computer Science 2016-05-27 Camille Marchet , Antoine Limasset , Lucie Bittner , Pierre Peterlongo

Recent excitement in the database community surrounding new applications?analytic, scientific, graph, geospatial, etc.?has led to an explosion in research on database storage systems. New storage systems are vital to the database community,…

Databases · Computer Science 2009-09-15 Philippe Cudre-Mauroux , Eugene Wu , Sam Madden

A Robotic Mobile Fulfillment System is a robotised parts-to-picker system that is particularly well-suited for e-commerce warehousing. One distinguishing feature of this type of warehouse is its high storage modularity. Numerous robots are…

Metasurfaces are ultrathin, engineered materials composed of nanostructures that manipulate light in ways unattainable by natural materials. Recent advances have leveraged computational optimization, machine learning, and deep learning to…

Optics · Physics 2025-08-08 Hao Li , Andrey Bogdanov

Enzyme design plays a crucial role in both industrial production and biology. However, this field faces challenges due to the lack of comprehensive benchmarks and the complexity of enzyme design tasks, leading to a dearth of systematic…

Biomolecules · Quantitative Biology 2024-08-21 Jiangbin Zheng , Han Zhang , Qianqing Xu , An-Ping Zeng , Stan Z. Li

Traces and logs serve as the backbone of observability in microservice architectures, yet their sheer volume imposes prohibitive storage and computational burdens. To reduce overhead, operators rely on sampling; however, current frameworks…

Software Engineering · Computer Science 2026-02-05 Zhouruixing Zhu , Zhihan Jiang , Tianyi Yang , Pinjia He

FastCAR is a novel task consolidation approach in Multi-Task Learning (MTL) for a classification and a regression task, despite task heterogeneity with only subtle correlation. It addresses object classification and continuous property…

Computer Vision and Pattern Recognition · Computer Science 2025-06-03 Anoop Kini , Andreas Jansche , Timo Bernthaler , Gerhard Schneider

Scientific applications produce vast amounts of data, posing grand challenges in the underlying data management and analytic tasks. Progressive compression is a promising way to address this problem, as it allows for on-demand data…

Distributed, Parallel, and Cluster Computing · Computer Science 2025-05-02 Yanliang Li , Wenbo Li , Qian Gong , Qing Liu , Norbert Podhorszki , Scott Klasky , Xin Liang , Jieyang Chen

The rapid expansion of Earth Science data from satellite observations, reanalysis products, and numerical simulations has created a critical bottleneck in scientific discovery, namely identifying relevant datasets for a given research…

Databases · Computer Science 2026-03-03 Youran Sun , Yixin Wen , Haizhao Yang

The Jaccard similarity index is an important measure of the overlap of two sets, widely used in machine learning, computational genomics, information retrieval, and many other areas. We design and implement SimilarityAtScale, the first…

Computational Engineering, Finance, and Science · Computer Science 2020-11-12 Maciej Besta , Raghavendra Kanakagiri , Harun Mustafa , Mikhail Karasikov , Gunnar Rätsch , Torsten Hoefler , Edgar Solomonik
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