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Tree structures appear in many fields of the life sciences, including phylogenetics, developmental biology and nucleic acid structures. Trees can be used to represent RNA secondary structures, which directly relate to the function of…

Machine Learning · Computer Science 2026-01-22 Pengyu Liu , Mariel Vázquez , Nataša Jonoska

When performing an analysis on a collection of molecular sequences, it can be convenient to reduce the number of sequences under consideration while maintaining some characteristic of a larger collection of sequences. For example, one may…

Populations and Evolution · Quantitative Biology 2012-09-03 Frederick A. Matsen , Aaron Gallagher , Connor McCoy

The orthogonal matching pursuit (OMP) is one of the mainstream algorithms for sparse data reconstruction or approximation. It acts as a driving force for the development of several other greedy methods for sparse data reconstruction, and it…

Information Theory · Computer Science 2023-03-31 Yun-Bin Zhao , Zhi-Quan Luo

Bayesian phylogenetics is vital for understanding evolutionary dynamics, and requires accurate and efficient approximation of posterior distributions over trees. In this work, we develop a variational Bayesian approach for ultrametric…

Machine Learning · Statistics 2026-02-16 Evan Sidrow , Alexandre Bouchard-Côté , Lloyd T. Elliott

Subsampling algorithms for various parametric regression models with massive data have been extensively investigated in recent years. However, all existing studies on subsampling heavily rely on clean massive data. In practical…

Statistics Theory · Mathematics 2025-06-11 Jiangshan Ju , Mingqiu Wang , Shengli Zhao

This paper studies the policy mirror descent (PMD) method, which is a general policy optimization framework in reinforcement learning and can cover a wide range of policy gradient methods by specifying difference mirror maps. Existing…

Optimization and Control · Mathematics 2026-01-01 Wenye Li , Hongxu Chen , Jiacai Liu , Ke Wei

Trees have long been used as a graphical representation of species relationships. However complex evolutionary events, such as genetic reassortments or hybrid speciations which occur commonly in viruses, bacteria and plants, do not fit into…

Populations and Evolution · Quantitative Biology 2017-07-24 Sebastien Roch , Kun-Chieh Wang

Several structural learning algorithms for staged tree models, an asymmetric extension of Bayesian networks, have been defined. However, they do not scale efficiently as the number of variables considered increases. Here we introduce the…

Machine Learning · Statistics 2022-06-15 Manuele Leonelli , Gherardo Varando

We provide time- and sample-efficient algorithms for learning and testing latent-tree Ising models, i.e. Ising models that may only be observed at their leaf nodes. On the learning side, we obtain efficient algorithms for learning a…

Machine Learning · Computer Science 2023-07-11 Davin Choo , Yuval Dagan , Constantinos Daskalakis , Anthimos Vardis Kandiros

Ensemble methods are among the state-of-the-art predictive modeling approaches. Applied to modern big data, these methods often require a large number of sub-learners, where the complexity of each learner typically grows with the size of…

Machine Learning · Computer Science 2018-10-29 Amichai Painsky , Saharon Rosset

The search for similarity and dissimilarity measures on phylogenetic trees has been motivated by the computation of consensus trees, the search by similarity in phylogenetic databases, and the assessment of clustering results in…

Populations and Evolution · Quantitative Biology 2011-11-09 Francesc Rossello , Gabriel Valiente

We devise a generalization of tree approximation that generates conforming meshes, i.e., meshes with a particular structure like edge-to-edge triangulations. A key feature of this generalization is that the choices of the cells to be…

Numerical Analysis · Mathematics 2023-01-26 Peter Binev , Francesca Fierro , Andreas Veeser

Recently, much attention has been given to understanding recombination events along a chromosome in a variety of field. For instance, many population genetics problems are limited by the inaccuracy of inferred evolutionary histories of…

Quantitative Methods · Quantitative Biology 2017-10-31 Jacqueline Kane , Joseph Rusinko , Katherine Thompson

The multispecies coalescent process models the genealogical relationships of genes sampled from several species, enabling useful predictions about phenomena such as the discordance between the gene tree and the species phylogeny due to…

Populations and Evolution · Quantitative Biology 2020-12-11 Jakub Truszkowski , Celine Scornavacca , Fabio Pardi

In the following paper we consider a simulation technique for stochastic trees. One of the most important areas in computational genetics is the calculation and subsequent maximization of the likelihood function associated to such models.…

Computation · Statistics 2015-05-20 Ajay Jasra , Maria De Iorio , Marc Chadeau-Hyam

In recent work, robust mixture modelling approaches using skewed distributions have been explored to accommodate asymmetric data. We introduce parsimony by developing skew-t and skew-normal analogues of the popular GPCM family that employ…

Methodology · Statistics 2013-11-12 Irene Vrbik , Paul D. McNicholas

Phylogenetic analyses which include fossils or molecular sequences that are sampled through time require models that allow one sample to be a direct ancestor of another sample. As previously available phylogenetic inference tools assume…

Populations and Evolution · Quantitative Biology 2014-12-08 Alexandra Gavryushkina , David Welch , Tanja Stadler , Alexei Drummond

Statistically consistent estimation of phylogenetic trees or gene trees is possible if pairwise sequence dissimilarities can be converted to a set of distances that are proportional to the true evolutionary distances. Susko et al. (2004)…

Populations and Evolution · Quantitative Biology 2015-04-28 Emily Jane McTavish , Mike Steel , Mark T. Holder

When using machine learning for imbalanced binary classification problems, it is common to subsample the majority class to create a (more) balanced training dataset. This biases the model's predictions because the model learns from data…

Machine Learning · Computer Science 2025-11-03 Nathan Phelps , Daniel J. Lizotte , Douglas G. Woolford

We give a 2-approximation algorithm for the Maximum Agreement Forest problem on two rooted binary trees. This NP-hard problem has been studied extensively in the past two decades, since it can be used to compute the Subtree…

Data Structures and Algorithms · Computer Science 2016-04-29 Frans Schalekamp , Anke van Zuylen , Suzanne van der Ster