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The abrupt outbreak and transmission of biological diseases has always been a long-time concern of humankind. For long, mathematical modeling has served as a simple and yet efficient tool to investigate, predict, and control spread of…

Populations and Evolution · Quantitative Biology 2020-04-10 Aresh Dadlani , Richard O. Afolabi , Hyoyoung Jung , Khosrow Sohraby , Kiseon Kim

Note: Published now as a chapter in "Handbook of the History and Philosophy of Mathematical Practice" (Springer Nature, editor B. Sriraman, https://doi.org/10.1007/978-3-030-19071-2_105-1). The application of mathematical probability theory…

Other Statistics · Statistics 2023-11-21 Christian Hennig

Quantifying model uncertainty is critical for understanding prediction reliability, yet distinguishing between aleatoric and epistemic uncertainty remains challenging. We extend recent work from classification to regression to provide a…

This paper examines the foundational concept of random variables in probability theory and statistical inference, demonstrating that their mathematical definition requires no reference to randomization or hypothetical repeated sampling. We…

Other Statistics · Statistics 2025-02-11 Paul W. Vos

The principle of maximum entropy is a broadly applicable technique for computing a distribution with the least amount of information possible constrained to match empirical data, for instance, feature expectations. We seek to generalize…

Information Theory · Computer Science 2022-05-30 Kenneth Bogert

Traditional statistical theory assumes that the analysis to be performed on a given data set is selected independently of the data themselves. This assumption breaks downs when data are re-used across analyses and the analysis to be…

Machine Learning · Computer Science 2017-06-06 Adam Smith

In an age of increasingly large data sets, investigators in many different disciplines have turned to clustering as a tool for data analysis and exploration. Existing clustering methods, however, typically depend on several nontrivial…

Quantitative Methods · Quantitative Biology 2009-11-11 Noam Slonim , Gurinder Singh Atwal , Gasper Tkacik , William Bialek

Statistical inference, a central tool of science, revolves around the study and the usage of statistical estimators: functions that map finite samples to predictions about unknown distribution parameters. In the frequentist framework,…

Machine Learning · Computer Science 2025-12-15 Maxime Peyrard , Kyunghyun Cho

Graphical models can represent a multivariate distribution in a convenient and accessible form as a graph. Causal models can be viewed as a special class of graphical models that not only represent the distribution of the observed system…

Methodology · Statistics 2017-06-29 Christina Heinze-Deml , Marloes H. Maathuis , Nicolai Meinshausen

Meta-analysis is a systematic approach for understanding a phenomenon by analyzing the results of many previously published experimental studies. It is central to deriving conclusions about the summary effect of treatments and interventions…

Computers and Society · Computer Science 2021-04-13 Lu Cheng , Dmitriy A. Katz-Rogozhnikov , Kush R. Varshney , Ioana Baldini

In scientific inference problems, the underlying statistical modeling assumptions have a crucial impact on the end results. There exist, however, only a few automatic means for validating these fundamental modelling assumptions. The…

Methodology · Statistics 2019-05-21 Andreas Svensson , Dave Zachariah , Petre Stoica , Thomas B. Schön

One can argue that one of the main roles of the subject of statistics is to characterize what the evidence in collected data says about questions of scientific interest. There are two broad questions that we will refer to as the estimation…

Statistics Theory · Mathematics 2024-06-11 Michael Evans

Information flow analysis has largely ignored the setting where the analyst has neither control over nor a complete model of the analyzed system. We formalize such limited information flow analyses and study an instance of it: detecting the…

Cryptography and Security · Computer Science 2014-05-13 Michael Carl Tschantz , Amit Datta , Anupam Datta , Jeannette M. Wing

Taking the Fourier integral theorem as our starting point, in this paper we focus on natural Monte Carlo and fully nonparametric estimators of multivariate distributions and conditional distribution functions. We do this without the need…

Methodology · Statistics 2021-06-15 Nhat Ho , Stephen G. Walker

Data analyses are often constructed in an imperative manner, where commands representing actions taken on the data are issued sequentially. The publication of these commands, along with the data, is essential to the reproducibility of the…

Other Statistics · Statistics 2026-03-12 Roger D. Peng

Meta-analysis, by synthesizing effect estimates from multiple studies conducted in diverse settings, stands at the top of the evidence hierarchy in clinical research. Yet, conventional approaches based on fixed- or random-effects models…

We revisit the replica method for analyzing inference and learning in parametric models, considering situations where the data-generating distribution is unknown or analytically intractable. Instead of assuming idealized distributions to…

Disordered Systems and Neural Networks · Physics 2025-11-17 Takashi Takahashi

Probability models are only useful at explaining the uncertainty of what we do not know, and should never be used to say what we already know. Probability and statistical models are useless at discerning cause. Classical statistical…

Other Statistics · Statistics 2015-07-30 William M. Briggs

The present communication addresses a set of observations, obeying both deterministic as well as statistical formal requirements, and serving to operate within the framework of the dynamical systems theory, with a certain emphasis placed on…

Physics and Society · Physics 2017-06-30 Adam Gadomski , Marcel Ausloos , Tahlia Casey

Categorical data are common in educational and social science research; however, methods for its analysis are generally not covered in introductory statistics courses. This chapter overviews fundamental concepts and methods in categorical…

Methodology · Statistics 2024-09-06 Dandan Chen , Carolyn Anderson
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