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We suggest that the propagation of the action potential is driven by a pressure pulse propagating in the axoplasm along the axon length. The pressure pulse mechanically activates Na ion channels embedded in the axon membrane. This…

Biological Physics · Physics 2009-05-15 Marat M. Rvachev

Detonation propagation in a compressible medium wherein the energy release has been made spatially inhomogeneous is examined via numerical simulation. The inhomogeneity is introduced via step functions in the reaction progress variable,…

We generalize the Cable Model to describe the transport characteristics of the gap junctions coupling adjacent cells in the heart muscle. Our model takes into account recent experimental information about the time dependence of the…

Pattern Formation and Solitons · Physics 2018-09-05 Isabel M. Irurzun , Magdalena M. Defeo

Formation of feedback loops of excitation waves (reentrant circuit) around non-conducting ventricular scar tissue is a common cause of lethal cardiac arrhythmias, such as ventricular tachycardia. This is typically treated by rapid…

Chaotic Dynamics · Physics 2007-05-23 Sitabhra Sinha , Johannes Breuer

Atrial Fibrillation (AF) is characterized by disorganised electrical activity in the atria and is known to be sustained by the presence of regions of fibrosis (scars) or functional cellular remodeling, both of which may lead to areas of…

Turbulent, relativistic nonthermal plasmas are ubiquitous in high-energy astrophysical systems, as inferred from broadband nonthermal emission spectra. The underlying turbulent nonthermal particle acceleration (NTPA) processes have…

High Energy Astrophysical Phenomena · Physics 2025-10-08 Kai W. Wong , Vladimir Zhdankin , Dmitri A. Uzdensky , Gregory R. Werner , Mitchell C. Begelman

Living cells employ excitable reaction-diffusion waves for internal cellular functions, in which curvature-inducing proteins are often involved. However, the role of their mechanochemical coupling is not well understood. Here, we report the…

Soft Condensed Matter · Physics 2022-08-09 Naoki Tamemoto , Hiroshi Noguchi

In this paper we develop theoretical analysis and numerical reconstruction techniques for the solution of an inverse boundary value problem dealing with the nonlinear, time-dependent monodomain equation, which models the evolution of the…

Analysis of PDEs · Mathematics 2017-01-27 Elena Beretta , Cecilia Cavaterra , Maria Cristina Cerutti , Andrea Manzoni , Luca Ratti

The process of particle acceleration by left-hand, circularly polarised inertial Alfven waves (IAW) in a transversely inhomogeneous plasma is studied using 3D particle-in-cell simulation. A cylindrical tube with, transverse to the…

Solar and Stellar Astrophysics · Physics 2015-03-13 D. Tsiklauri

We investigate different mechanical effects which accompany the nerve pulse propagation by using mathematical modeling. The propagation process is composed by three connected phenomena: (i) the action potential (electrical signal) which is…

Biological Physics · Physics 2019-06-05 Kert Tamm , Tanel Peets , Jüri Engelbrecht

We derive an equation that governs the spatiotemporal dynamics of small amplitude alternans in paced cardiac tissue. We show that a pattern-forming linear instability leads to the spontaneous formation of stationary or traveling waves whose…

Statistical Mechanics · Physics 2009-11-07 Blas Echebarria , Alain Karma

We study the homogenization of a novel microscopic tridomain system, allowing for a more detailed analysis of the properties of cardiac conduction than the classical bidomain and monodomain models. In (Acta Appl.Math. 179 (2022) 1--35), we…

Analysis of PDEs · Mathematics 2022-09-16 Fakhrielddine Bader , Mostafa Bendahmane , Mazen Saad , Raafat Talhouk

Background and Objective: This proof of concept study investigates mathematical modelling of blood flow and oxygen transport in cerebral microcirculation, focusing on understanding hemodynamic responses. By coupling oxygen transport models…

Numerical Analysis · Mathematics 2024-11-19 Maryam Samavaki , Santtu Söderholm , Arash Zarrin Nia , Sampsa Pursiainen

Atrial fibrillation is a clinical arrhythmia with multifactorial mechanisms still unresolved. Time-frequency analysis of epicardial electrograms has been investigated to study atrial fibrillation. However, deeper understanding of atrial…

Signal Processing · Electrical Eng. & Systems 2019-10-15 Miao Sun , Elvin Isufi , Natasja M. S. de Groot , Richard C. Hendriks

Non-invasive assessment of the electrical activation pattern can significantly contribute to the diagnosis and treatment of cardiac arrhythmias, due to faster and safer diagnosis, improved surgical planning and easier follow-up. One…

Medical Physics · Physics 2024-01-09 Nathan Dermul , Hans Dierckx

In this paper, we present an analytic solution for pulse wave propagation in a flexible arterial model with tapering, physiological boundary conditions and variable wall properties (wall elasticity and thickness). The change of wall…

Fluid Dynamics · Physics 2023-12-20 Peishuo Wu , Chi Zhu

Type III radio bursts are radio emissions associated with solar flares. They are considered to be caused by electron beams traveling from the solar corona to the solar wind. Magnetic reconnection is a possible accelerator of electron beams…

Plasma Physics · Physics 2021-03-17 Xin Yao , Patricio A. Muñoz , Jörg Büchner , Xiaowei Zhou , Siming Liu

Reentry around non-conducting ventricular scar tissue, which often causes lethal arrhythmias, is typically treated by rapid stimulation from an implantable defibrillator. However, the mechanisms of termination (success and failure) are…

Chaotic Dynamics · Physics 2007-05-23 Sitabhra Sinha , David J. Christini

Heart rate variability results from the combined activity of several physiological systems, including the cardiac, vascular, and respiratory systems which have their own internal regulation, but also interact with each other to preserve the…

In this numerical study, we investigate the role of intrinsic heterogeneities of cardiac tissue due to M cells in the generation and maintenance of reentrant excitations using the detailed Luo-Rudy dynamic model. This model has been…

Tissues and Organs · Quantitative Biology 2007-05-23 Hervé Henry , Wouter-Jan Rappel